Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases. Journal of inflammation research Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases. 10.2147/JIR.S350109

Quantum Lyapunov exponent in dissipative systems. Physical review. E The out-of-time order correlator (OTOC) has been widely studied in closed quantum systems. However, there are very few studies for open systems and they are mainly focused on isolating the effects of scrambling from those of decoherence. Adopting a different point of view, we study the interplay between these two processes. This proves crucial in order to explain the OTOC behavior when a phase space contracting dissipation is present, ubiquitous not only in real life quantum devices but in the dynamical systems area. The OTOC decay rate is closely related to the classical Lyapunov exponent-with some differences-and more sensitive in order to distinguish the chaotic from the regular behavior than other measures. On the other hand, it is revealed as a generally simple function of the longest lived eigenvalues of the quantum evolution operator. We find no simple connection with the Ruelle-Pollicott resonances, but by adding Gaussian noise of ℏ_{eff} size to the classical system we recover the OTOC decay rate, which is a consequence of the correspondence principle put forward in Phys. Rev. Lett. 108, 210605 (2012)10.1103/PhysRevLett.108.210605 and Phys. Rev. E 99, 042214 (2019)10.1103/PhysRevE.99.042214. 10.1103/PhysRevE.108.024208