AI总结:根据提供的论文名称列表,整体内容主要围绕磷脂酶A2(Phospholipase A2, PLA2)在医学领域的研究展开。以下是对这些论文的综合摘要:<div style='margin:15px 0'>---</div>磷脂酶A2(PLA2)作为一类重要的酶,在细胞信号传导、生物化学机制以及疾病发生发展中扮演了关键角色。本组论文聚焦于PLA2的生理功能、结构特性、作用机制及其与疾病的关联。具体而言,研究探讨了胞质型磷脂酶A2(cPLA2)的生物学功能及其在病理条件下的作用,同时深入分析了PLA2 A2亚型的分子结构与功能关系。此外,论文还涉及PLA2在信号通路中的调控机制,以及其在炎症、肿瘤等疾病中的潜在病理意义。通过结合生物化学、结构生物学和细胞信号转导的研究方法,这些论文为理解PLA2的功能及其在疾病治疗中的应用提供了重要理论基础。<div style='margin:15px 0'></div>--- <div style='margin:15px 0'></div>此摘要总结了论文的核心主题,并突出了医学相关的术语和研究方向。
Scan me!
共1篇 平均IF=7.6 (7.6-7.6)更多分析
  • 1区Q1影响因子: 7.6
    打开PDF
    1. Total 18F-dopa PET tumour uptake reflects metabolic endocrine tumour activity in patients with a carcinoid tumour.
    作者:Fiebrich Helle-Brit , de Jong Johan R , Kema Ido P , Koopmans Klaas Pieter , Sluiter Wim , Dierckx Rudi A J O , Walenkamp Annemiek M , Links Thera P , Brouwers Adrienne H , de Vries Elisabeth G E
    期刊:European journal of nuclear medicine and molecular imaging
    日期:2011-06-23
    DOI :10.1007/s00259-011-1862-5
    PURPOSE:Positron emission tomography (PET) using 6-[18F]fluoro-L-dihydroxyphenylalanine (18F-dopa) has an excellent sensitivity to detect carcinoid tumour lesions. 18F-dopa tumour uptake and the levels of biochemical tumour markers are mediated by tumour endocrine metabolic activity. We evaluated whether total 18F-dopa tumour uptake on PET, defined as whole-body metabolic tumour burden (WBMTB), reflects tumour load per patient, as measured with tumour markers. METHODS:Seventy-seven consecutive carcinoid patients who underwent an 18F-dopa PET scan in two previously published studies were analysed. For all tumour lesions mean standardised uptake values (SUVs) at 40% of the maximal SUV and tumour volume on 18F-dopa PET were determined and multiplied to calculate a metabolic burden per lesion. WBMTB was the sum of the metabolic burden of all individual lesions per patient. The 24-h urinary serotonin, urine and plasma 5-hydroxindoleacetic acid (5-HIAA), catecholamines (nor)epinephrine, dopamine and their metabolites, measured in urine and plasma, and serum chromogranin A served as tumour markers. RESULTS:All but 1 were evaluable for WBMTB; 74 patients had metastatic disease. 18F-dopa PET detected 979 lesions. SUVmax on 18F-dopa PET varied up to 29-fold between individual lesions within the same patients. WBMTB correlated with urinary serotonin (r=0.51) and urinary and plasma 5-HIAA (r=0.78 and 0.66). WBMTB also correlated with urinary norepinephrine, epinephrine, dopamine and plasma dopamine, but not with serum chromogranin A. CONCLUSION:Tumour load per patient measured with 18F-dopa PET correlates with tumour markers of the serotonin and catecholamine pathway in urine and plasma in carcinoid patients, reflecting metabolic tumour activity.
logo logo
$!{favoriteKeywords}