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Searching for an Elusive Phantom - Targeting Estrogen in Pulmonary Hypertension. American journal of respiratory and critical care medicine 10.1164/rccm.202405-1029ED
Mitochondria as a primary determinant of angiogenic modality in pulmonary arterial hypertension. The Journal of experimental medicine Impaired pulmonary angiogenesis plays a pivotal role in the progression of pulmonary arterial hypertension (PAH) and patient mortality, yet the molecular mechanisms driving this process remain enigmatic. Our study uncovered a striking connection between mitochondrial dysfunction (MD), caused by a humanized mutation in the NFU1 gene, and severely disrupted pulmonary angiogenesis in adult lungs. Restoring the bioavailability of the NFU1 downstream target, lipoic acid (LA), alleviated MD and angiogenic deficiency and rescued the progressive PAH phenotype in the NFU1G206C model. Notably, significant NFU1 expression and signaling insufficiencies were also identified in idiopathic PAH (iPAH) patients' lungs, emphasizing this study's relevance beyond NFU1 mutation cases. The remarkable improvement in mitochondrial function of PAH patient-derived pulmonary artery endothelial cells (PAECs) following LA supplementation introduces LA as a potential therapeutic approach. In conclusion, this study unveils a novel role for MD in dysregulated pulmonary angiogenesis and PAH manifestation, emphasizing the need to correct MD in PAH patients with unrecognized NFU1/LA deficiency. 10.1084/jem.20231568
Pulmonary Hypertension: From Therapeutic Nihilism to Multiple Therapeutic Interventions. Circulation 10.1161/CIRCULATIONAHA.124.070104