AI总结:根据提供的论文列表,这些研究主要围绕牙齿发育、再生医学以及相关分子机制展开,涉及多个医学领域的关键主题。以下是整体摘要:---上述论文集合聚焦于牙齿发育、组织工程及再生医学的分子与细胞机制,探讨了从胚胎发育到临床应用的多方面内容。具体而言,研究涵盖了以下几个核心领域:1. **牙齿发育的分子调控**:部分论文深入分析了蛋白糖基化(Proteoglycans)和糖胺聚糖(Glycosaminoglycans)在牙发生过程中的作用,揭示了这些生物大分子对牙齿形态建成和功能实现的关键影响。2. **再生医学与组织工程**:多篇论文关注牙齿及其支持组织(如牙周膜、牙本质等)的再生机制,特别是通过干细胞生物学和信号通路的研究,探索牙齿再生的可能性。例如,KDM2B等表观遗传因子被发现可能在早期牙齿发育中起到调控作用。3. **细胞与分子动力学**:一些研究详细描述了牙齿发育过程中细胞迁移、增殖及分化的时空动态特征,并结合分子水平的调控网络,阐明了牙齿根部形成及牙髓组织构建的具体机制。4. **信号传导与机械力学**:机械力(Mechanical stress)在牙齿发育中的作用也被广泛提及,尤其是在诱导信号中心(Signaling center)形成和组织模式化方面的贡献。此外,小分子如何直接或间接驱动牙齿发育的分子机制也得到了深入探讨。5. **临床转化潜力**:部分研究进一步延伸至临床应用层面,评估了氧化应激(Oxidative stress)、基因编辑技术及其他干预手段在促进牙齿再生中的可行性,为未来治疗策略提供了理论依据。综上所述,该论文集全面覆盖了牙齿发育的基础研究与临床转化方向,不仅深化了我们对牙齿形成机制的理解,还为牙科疾病的预防与治疗提供了新的思路和方法。--- 希望这一总结能满足您的需求!如有其他问题,请随时告知。
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共5篇 平均IF=5.2 (2.3-14.3)更多分析
  • 1区Q1影响因子: 9.1
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    1. Spatiotemporal dynamics of animal contests arise from effective forces between contestants.
    1. 时空动态的动物比赛源自参赛者之间的有效力量。
    期刊:Proceedings of the National Academy of Sciences of the United States of America
    日期:2021-12-07
    DOI :10.1073/pnas.2106269118
    Competition among animals for resources, notably food, territories, and mates, is ubiquitous at all scales of life. This competition is often resolved through contests among individuals, which are commonly understood according to their outcomes and in particular, how these outcomes depend on decision-making by the contestants. Because they are restricted to end-point predictions, these approaches cannot predict real-time or real-space dynamics of animal contest behavior. This limitation can be overcome by studying systems that feature typical contest behavior while being simple enough to track and model. Here, we propose to use such systems to construct a theoretical framework that describes real-time movements and behaviors of animal contestants. We study the spatiotemporal dynamics of contests in an orb-weaving spider, in which all the common elements of animal contests play out. The confined arena of the web, on which interactions are dominated by vibratory cues in a two-dimensional space, simplifies the analysis of interagent interactions. We ask whether these seemingly complex decision-makers can be modeled as interacting active particles responding only to effective forces of attraction and repulsion due to their interactions. By analyzing the emergent dynamics of "contestant particles," we provide mechanistic explanations for real-time dynamical aspects of animal contests, thereby explaining competitive advantages of larger competitors and demonstrating that complex decision-making need not be invoked in animal contests to achieve adaptive outcomes. Our results demonstrate that physics-based classification and modeling, in terms of effective rules of interaction, provide a powerful framework for understanding animal contest behaviors.
  • 1区Q1影响因子: 14.3
    2. Is temporo-spatial dynamics the "common currency" of brain and mind? In Quest of "Spatiotemporal Neuroscience".
    2. 是temporo-spatial动力学大脑和思维的“通用货币”吗?探寻“时空神经科学”。
    作者:Northoff Georg , Wainio-Theberge Soren , Evers Kathinka
    期刊:Physics of life reviews
    日期:2019-05-23
    DOI :10.1016/j.plrev.2019.05.002
    Neuroscience has made considerable progress in unraveling the neural correlates of mental phenomena like self, consciousness, and perception. However, the "common currency" shared between neuronal and mental activity, brain and mind, remains yet unclear. In this article, we propose that the dynamics of time and space provides a "common currency" that connects neuronal and mental features. Time and space are here understood in a dynamic context (as in contemporary physics): that is, in terms of the way the brain's spontaneous activity constructs its spatial and temporal relationships, for instance in terms of functional connectivity and different frequencies of fluctuations. Recruiting recent empirical evidence, we show that the different ways in which the spontaneous activity constructs its "inner time and space" are manifested in distinct mental features. Specifically, we demonstrate how spatiotemporal mechanisms like spatiotemporal repertoire, integration, and speed yield mental features like consciousness, self, and time speed perception. The focus on the brain's spatiotemporal mechanisms entails what we describe as "Spatiotemporal Neuroscience". Spatiotemporal Neuroscience conceives neuronal activity in terms of its temporo-spatial dynamics rather than its various functions (e.g., cognitive, affective, social, etc.) as in other branches of neuroscience (as distinguished from Cognitive, Affective, Cultural, Social, etc. Neuroscience). That allows Spatiotemporal Neuroscience to take into view the so-called 'spatio-temporality' of mental features including their non-causal, intrinsic and transformative relationship with neuronal features. In conclusion, Spatiotemporal Neuroscience opens the door to investigate and ultimately reveal the brain's own temporo-spatial dynamics as the hitherto missing "common currency" of neuronal and mental features.
  • 2区Q2影响因子: 5.2
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    3. Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions.
    3. 肿瘤坏死因子(TNF)是雄性小鼠在生理但非免疫挑战条件下空间学习和记忆所必需的。
    期刊:Cells
    日期:2021-03-09
    DOI :10.3390/cells10030608
    Increasing evidence demonstrates that inflammatory cytokines-such as tumor necrosis factor (TNF)-are produced at low levels in the brain under physiological conditions and may be crucial for synaptic plasticity, neurogenesis, learning and memory. Here, we examined the effects of developmental TNF deletion on spatial learning and memory using 11-13-month-old TNF knockout (KO) and C57BL6/J wild-type (WT) mice. The animals were tested in the Barnes maze (BM) arena under baseline conditions and 48 h following an injection of the endotoxin lipopolysaccharide (LPS), which was administered at a dose of 0.5 mg/kg. Vehicle-treated KO mice were impaired compared to WT mice during the acquisition and memory-probing phases of the BM test. No behavioral differences were observed between WT and TNF-KO mice after LPS treatment. Moreover, there were no differences in the hippocampal content of glutamate and noradrenaline between groups. The effects of TNF deletion on spatial learning and memory were observed in male, but not female mice, which were not different compared to WT mice under baseline conditions. These results indicate that TNF is required for spatial learning and memory in male mice under physiological, non-inflammatory conditions, however not following the administration of LPS. Inflammatory signalling can thereby modulate spatial cognition in male subjects, highlighting the importance of sex- and probably age-stratified analysis when examining the role of TNF in the brain.
  • 3区Q2影响因子: 2.3
    4. Adult neurogenesis promotes efficient, nonspecific search strategies in a spatial alternation water maze task.
    4. 成人神经发生在空间交替的水迷宫任务中促进有效的,非特异性的搜索策略。
    作者:Yu Ru Qi , Cooke Matthew , Seib Desiree R , Zhao Jiaying , Snyder Jason S
    期刊:Behavioural brain research
    日期:2019-08-22
    DOI :10.1016/j.bbr.2019.112151
    Goal-directed navigation requires learning strategies that are efficient and minimize costs. In some cases it may be desirable to flexibly adjust behavioral responses depending on the cues that vary from one episode to the next. In others, successful navigation might be achieved with inflexible, habit-like responses that reduce cognitive load. Adult neurogenesis is believed to contribute to the spatial processing functions of the hippocampus, particularly when behavioral flexibility is required. However, little is known about the role of neurogenesis in spatial navigation when goals are unpredictable or change repeatedly according to certain rules. We hypothesized that neurogenesis is necessary in a spatial navigation task that involves different patterns of reinforcement. Intact and neurogenesis-deficient rats were trained to escape to one of two possible platform locations in a spatial water maze. The platform either repeated in the same location for all trials in a day, alternated between two locations across trials, or randomly moved between the two locations. Neurogenesis selectively enhanced escape performance in the alternating condition, but not by improving platform choice accuracy. Instead, neurogenesis-intact rats made fewer search errors and developed an efficient habit-like strategy where they consistently swam to a preferred location. If the platform was not present, they proceeded to the other possible location. In contrast, neurogenesis-deficient rats were indecisive and navigationally less-efficient. Thus, in conditions where goals follow a predictable spatiotemporal pattern, adult neurogenesis promotes the adoption of navigation strategies that are spatially nonspecific but, nonetheless, accurate and efficient.
  • 3区Q1影响因子: 4.5
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    5. Uncovering spatial representations from spatiotemporal patterns of rodent hippocampal field potentials.
    5. 从啮齿动物海马场电位的时空模式中揭示空间表征。
    期刊:Cell reports methods
    日期:2021-10-25
    DOI :10.1016/j.crmeth.2021.100101
    Spatiotemporal patterns of large-scale spiking and field potentials of the rodent hippocampus encode spatial representations during maze runs, immobility, and sleep. Here, we show that multisite hippocampal field potential amplitude at ultra-high-frequency band (FPA), a generalized form of multiunit activity, provides not only a fast and reliable reconstruction of the rodent's position when awake, but also a readout of replay content during sharp-wave ripples. This FPA feature may serve as a robust real-time decoding strategy from large-scale recordings in closed-loop experiments. Furthermore, we develop unsupervised learning approaches to extract low-dimensional spatiotemporal FPA features during run and ripple periods and to infer latent dynamical structures from lower-rank FPA features. We also develop an optical flow-based method to identify propagating spatiotemporal LFP patterns from multisite array recordings, which can be used as a decoding application. Finally, we develop a prospective decoding strategy to predict an animal's future decision in goal-directed navigation.
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