AI总结:上述论文列表主要围绕**肝脏疾病**中的一个特殊病理现象——**肝周血管外皮细胞瘤(Perivascular Epithelioid Cell Tumor, PEComa)**展开研究。这些论文从多个角度探讨了PEComa的临床特征、诊断难点、病理分型以及治疗策略。整体来看,论文内容聚焦于以下医学主题:1. **PEComa的诊断与鉴别诊断**:多篇论文提到该肿瘤的罕见性和复杂性,强调其在影像学和组织病理学上的独特表现,并讨论了如何通过免疫组化标记等手段进行准确诊断。2. **病理分型与生物学行为**:部分研究对PEComa进行了良性、恶性及不确定潜能类型的分类分析,揭示了不同分型之间的差异及其对预后的影响。3. **病例报道与文献综述**:一些论文以具体病例为基础,结合现有文献深入探讨PEComa的发生机制、临床表现及治疗经验。4. **风险分层与治疗策略**:针对恶性PEComa或具有侵袭性的病例,论文提出了风险分层评估方法,并探讨了手术切除、靶向治疗及其他干预措施的应用价值。总体而言,这些研究为理解PEComa这一罕见病提供了重要参考,尤其在提高早期识别率、优化治疗方案方面具有重要意义。同时,也反映了当前医学界对该领域研究的持续关注与探索。
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共8篇 平均IF=4.3 (0.9-14)更多分析
  • 3区Q1影响因子: 4.3
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    1. Hepatic perivascular epithelioid cell tumors: The importance of preoperative diagnosis.
    期刊:World journal of gastroenterology
    日期:2024-04-07
    DOI :10.3748/wjg.v30.i13.1926
    Accurate preoperative diagnosis is highly important for the treatment of perivascular epithelioid cell tumors (PEComas) because PEComas are mainly benign tumors and may not require surgical intervention. By analyzing the causes, properties and clinical manifestations of PEComas, we summarize the challenges and solutions in the diagnosis of PEComas.
  • 1区Q1影响因子: 12.1
    2. Perivascular Epithelioid Cell Tumor of the Liver: A Rare and Difficult Case Diagnosis.
    期刊:Radiology
    日期:2025-01-01
    DOI :10.1148/radiol.241611
  • 4区Q2影响因子: 2.7
    3. Perivascular epithelioid cell tumor (PEComa) of the liver. An extremely rare diagnosis.
    期刊:Revista espanola de enfermedades digestivas
    日期:2023-06-01
    DOI :10.17235/reed.2023.9558/2023
    Hepatic PEComa are tumors that show perivascular epithelioid cell differentiation. Scarcely published, its management is based on small case series and currently its treatment of choice is surgical resection. We present a clinical case of a 74-year-old woman who underwent surgery at our hospital for a benign hepatic PEComa.
  • 3区Q2影响因子: 3.5
    4. A case report of a perivascular epithelioid cell tumor in the liver.
    期刊:Asian journal of surgery
    日期:2023-07-19
    DOI :10.1016/j.asjsur.2023.06.094
  • 3区Q1影响因子: 4.3
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    5. Hepatic perivascular epithelioid cell tumors: Benign, malignant, and uncertain malignant potential.
    期刊:World journal of gastroenterology
    日期:2024-05-14
    DOI :10.3748/wjg.v30.i18.2374
    In 2013, the World Health Organization defined perivascular epithelioid cell tumor (PEComa) as "a mesenchymal tumor which shows a local association with vessel walls and usually expresses melanocyte and smooth muscle markers." This generic definition seems to better fit the PEComa family, which includes angiomyolipoma, clear cell sugar tumor of the lung, lymphangioleiomyomatosis, and a group of histologically and immunophenotypically similar tumors that include primary extrapulmonary sugar tumor and clear cell myomelanocytic tumor. Clear cell tumors with this immunophenotypic pattern have also had their malignant variants described. When localizing to the liver, preoperative radiological diagnosis has proven to be very difficult, and most patients have been diagnosed with hepatocellular carcinoma, focal nodular hyperplasia, hemangioma, or hepatic adenoma based on imaging findings. Examples of a malignant variant of the liver have been described. Finally, reports of malignant variants of these lesions have increased in recent years. Therefore, we support the use of the Folpe criteria, which in 2005 established the criteria for categorizing a PEComa as benign, malignant, or of uncertain malignant potential. Although they are not considered ideal, they currently seem to be the best approach and could be used for the categorization of liver tumors.
  • 影响因子: 0.9
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    6. Malignant perivascular epithelioid cell tumor of the uterus.
    作者:Bleeker Jonathan S , Quevedo J Fernando , Folpe Andrew L
    期刊:Rare tumors
    日期:2012-03-12
    DOI :10.4081/rt.2012.e14
    Perivascular epithelioid cell tumors (PEComas) are a rare collection of tumors arising in a wide array of anatomic locations and characterized by a myomelanocytic phenotype. PEComas which occur in non-classic anatomic distributions are known as perivascular epithelioid cell tumor-not otherwise specified (PEComa-NOS), and one of the most common primary sites for PEComa-NOS is the uterus. The risk of aggressive behavior of these tumors has been linked to a number of factors evaluable on pathologic review following initial surgical resection. We report a case of PEComa-NOS of the uterus with multiple high-risk features, including frank vascular invasion, with no evidence of recurrent disease 18 months following initial surgical resection.
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    7. "Malignant" perivascular epithelioid cell neoplasm: risk stratification and treatment strategies.
    作者:Bleeker Jonathan S , Quevedo J Fernando , Folpe Andrew L
    期刊:Sarcoma
    日期:2012-04-26
    DOI :10.1155/2012/541626
    Purpose. Perivascular epithelioid cell tumors (PEComas) are a rare collection of tumors characterized by a myomelanocytic phenotype, and PEComas occurring in "nonclassic" anatomic distributions are known as perivascular epithelioid cell tumor not otherwise specified (PEComa-NOS). This review aims to compile and analyze cases of PEComa-NOS in an effort to better define their natural history. Design. We evaluated all 234 cases of PEComa-NOS reported in the English literature, extracting information regarding diagnostic features, treatment approaches, and outcomes. Multivariate analysis of a number of variables evaluable on pathologic review was performed to refine preexisting risk stratification criteria. Outcomes for patients receiving nonsurgical treatment are also reported. Results. Primary tumor size ≥5 cm (P = 0.02) and a high (1/50 HPF) mitotic rate (P < 0.0001) were the only factors significantly associated with recurrence following surgical resection. Cytotoxic chemotherapy and radiation therapy have shown little benefit in treating PEComa-NOS; mTOR inhibition is emerging as a treatment option. Conclusion. Progress has been made in understanding the natural history and molecular biology of PEComa-NOS. This review further clarifies risk of recurrence in this disease, allowing clinicians to better risk stratify patients. Further work should focus on applying this knowledge to making treatment decisions for patients with this disease.
  • 1区Q1影响因子: 14
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    8. Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures.
    作者:Son Hyun-Jin , Kang Dong Wook , Kim Joo Heon , Han Hyun Young , Lee Min Koo
    期刊:Clinical and molecular hepatology
    日期:2017-03-14
    DOI :10.3350/cmh.2016.0034
    Hepatic perivascular epithelioid cell tumors (PEComas) are very rare. We report a primary hepatic PEComa with a review of the literature. A 56-year-old women presented with a nodular mass detected during the management of chronic renal failure and chronic hepatitis C. Diagnostic imaging studies suggested a nodular hepatocellular carcinoma in segment 5 of the liver. The patient underwent partial hepatectomy. A brown-colored expansile mass measuring 3.2×3.0 cm was relatively demarcated from the surrounding liver parenchyma. The tumor was mainly composed of epithelioid cells that were arranged in a trabecular growth pattern. Adipose tissue and thick-walled blood vessels were minimally identified. A small amount of extramedullary hematopoiesis was observed in the sinusoidal spaces between tumor cells. Tumor cells were diffusely immunoreactive for human melanoma black 45 (HMB45) and Melan A, focally immunoreactive for smooth muscle actin, but not for hepatocyte specific antigen (HSA).
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