Extranodal manifestation of Kimura's disease: ultrasound features.
Ching A S C,Tsang W M,Ahuja A T,Metreweli C
European radiology
We describe the imaging features of a 53-year-old Chinese patient with Kimura's disease (KD) who presented with a dominant right-cheek subcutaneous mass. The lesion appeared as an ill-defined mass within the subcutaneous tissues with a "wooly" echotexture on US. The differential diagnosis and a review of the literature are discussed.
10.1007/s003300100961
Kimura's Disease Presenting As Scrotal Mass: A Difficult Diagnosis.
Xie Deng Piao,Xu Yan Fang,Li Ming Quan
Urology journal
Herein we report a case of Kimura's disease with unusual manifestations. A 46-year- old Chinese man presented with mass in scrotum which gradually increased in size for approximately 7 years. A computerized tomographic scan of abdomen revealed a soft-tissue density shadow in scrotum and enlargement of lymph nodes in groin and retroperitoneum. The scrotal mass was excised and the biopsy specimen revealed angiolymphoid hyperplasia with infiltration of eosinophils. In conclusion, clinical doctors should pay attention that the patient with eosinophilia and scrotal mass could be indicative for Kimura's disease.
10.22037/uj.v0i0.4050
[Diagnostic value of Kimura's disease with ultrasonography].
Huang Weiqin,Tang Li'na,Shen Youhong,Zhang Ning,Ni Shixiong,Xie Wenting,Chen Yijie
Zhonghua yi xue za zhi
OBJECTIVE:To explore the diagnostic value of ultrasonography for Kimura's disease (KD). METHODS:Retrospectively analyzed the results of two dimension and color Doppler of 21 Kimura's disease carried by 19 patients who were resected and confirmed by pathologhy. RESULTS:Twenty-one KD cases were detected by the ultrasound while none of them was diagnosed by ultrasonography. 21 cases were showed in the lymph nodes (42.9%, 9/21), parotid gland (4.8%, 1/21) and soft tissues (52.4%, 11/21). The masses both in the lymph and in the parotid gland marked hypoechogenicity and round or like-round. Cases in the soft tissues marked hypoechogencity or hyperechogenicity. Color Doppler flow pattern II to III were showed in 19 cases (90.5%, 19/21). CONCLUSION:Ultrasonography enables a confident preoperative diagnosis of Kimura's disease.
A rare case of inguinal kimura disease.
Gregory X,Soon N I,Nur Aklina R
The Medical journal of Malaysia
Kimura's disease is a rare chronic inflammatory disease of unknown etiology, commonly presenting with painless lymphadenopathy and subcutaneous masses in the head and neck regions.1 However, presentations with inguinal lymphadenopathy are rare and mimics other differentials, may pose a diagnostic challenge. We present a case of a 50-year-old male, with right inguinal swelling for one month duration that was finally diagnosed with Kimura's Disease after a multitude of investigations to rule out differentials of lymphadenopathy, delaying conclusive treatment. Specialized test had been done resonated with the histopathological findings only. We report this case to increase awareness of Kimura's Disease.
Clinical analysis of Kimura's disease in 24 cases from China.
Zhang Guoliang,Li Xumao,Sun Guangbin,Cao Yitan,Gao Nan,Qi Weidong
BMC surgery
BACKGROUND:We reviewed details of Chinese Kimura's disease (KD) cases. A full clinical analysis was subsequently performed to improve the accuracy of clinical diagnosis and treatment of KD. METHODS:A total of 24 patients with pathologically confirmed KD treated between March 2008 and March 2018 were reviewed retrospectively for clinical and histopathological analysis. RESULTS:In the 24 KD cases, 20 were male and 4 were female with the age of onset ranging from 5 to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24 patients, 11 experienced recurrence of disease after treatment (surgical resection: 46.2%, surgical resection followed by oral corticosteroids: 71.4% and surgical resection combined with radiotherapy: 0%). CONCLUSIONS:Our analysis revealed clinical, imaging, and histological characteristics of KD. A better understanding of the disease will help clinicians reduce misdiagnosis and improve the diagnostic rate upon patient first clinical visit.
10.1186/s12893-019-0673-7
Kimura Disease: A Rare Cause of Head and Neck Tumour in Children- A Case Report.
Current medical imaging
BACKGROUND:Kimura disease is a rare inflammatory condition classically manifested as painless subcutaneous nodules in the head and neck region and associated with regional cervical lymphadenopathy and salivary gland involvement. OBJECTIVE:The purpose of this report is to illustrate the diagnostic difficulty due to its rarity and non-specific clinical presentation. CASE PRESENTATION:We present a case of Kimura disease with bilateral eyelid swelling, parotid involvement, and cervical lymphadenopathy in a young boy. Computed Tomography (CT) showed ill- defined enhancing masses in both upper eyelids with lacrimal gland infiltration, multiple nodular lesions in both parotid glands, and bilateral enlargement of cervical nodes. After several multidisciplinary discussions and trials of medications, Kimura's disease was finally confirmed by histology examination. CONCLUSION:In conclusion, a rare disease such as Kimura must be considered earlier if the patient is not responding to the treatment.
10.2174/1573405617666211029163214
Kimura's disease affecting the axillary lymph nodes: a case report.
Kuroda Kenji,Kashiwagi Shinichiro,Teraoka Hitoshi,Kinoshita Haruhito,Nanbara Mikio,Noda Eiji,Chikugo Takaaki,Hirakawa Kosei,Ohira Masaichi
BMC surgery
BACKGROUND:Kimura's disease (KD; eosinophilic granuloma of soft tissue) is an inflammatory granulomatous disorder of unknown cause with eosinophilic infiltration that occurs mainly in soft tissue. KD occurs mainly in the head and neck, but development in the axillary region is very rare. CASE PRESENTATION:A 74-year-old Japanese woman was evaluated for a mass that she noted in the left axillary region. On physical examination, there was a palpable, thumb-sized, hard, elastic, freely movable mass in the left axilla. Blood tests showed elevated soluble interleukin-2 receptor (sIL-2R), normal serum immunoglobulin (Ig) G4, and elevated serum IgE. Ultrasonography of the left axilla showed multiple lymph nodes (LNs) with irregular margins in which central hyperechogenicity was lost. A systemic search by computed tomography (CT) showed no systemic lymphadenopathy or other mass-like lesions suspicious for a primary tumour other than in the left axillary LNs. Biopsy of an excised LN was performed under local anaesthesia for a definitive diagnosis. Histopathology showed various-sized lymphoid follicles, large nodular lesions with an enlarged mantle zone, multiple various-sized germinal centres in single nodules, and eosinophilic infiltration between the nodes. Immunohistochemical (IHC) staining of the germinal centres was positive for cluster of differentiation (CD) 10, positive for B-cell lymphoma (bcl)-6, and negative for bcl-2. These findings led to a diagnosis of KD. Ultrasound after 3 months of follow-up showed disappearance of the axillary lymphadenopathy. CONCLUSIONS:A very rare case of KD in the axillary LNs was described. KD has the potential to occur in any region.
10.1186/s12893-017-0260-8
Ultrasound of Kimura's disease.
Ahuja A T,Loke T K,Mok C O,Chow L T,Metreweli C
Clinical radiology
Kimura's disease is found almost exclusively in Orientals. It commonly affects the head and neck region and mainly involves the major salivary glands and regional lymph nodes. Its appearances can be mistaken for malignant disease. We present two patients with Kimura's disease. In one patient the disease involved the soft tissues and parotid gland, and in another the submandibular gland. Both patients demonstrated lymphadenopathy in the submandibular, submental areas and upper cervical region. Both patients had ultrasound examination of the salivary glands and neck. One of the patients also had contrast-enhanced CT and MRI. The clinical, pathological and imaging findings of Kimura's disease are discussed.
Kimura's disease of the left arm.
BMJ case reports
Kimura's disease is a rare, benign entity that causes subcutaneous angioblastic lymphoid hyperplasia with eosinophilia. It usually presents with subcutaneous lymphoid swellings with regional lymphadenopathy and salivary gland masses. Kimura's disease is frequently associated with renal involvement, which includes proteinuria and nephrotic syndrome as the most common presentations. This report presents a case of a man in his early 20s with a swelling in the medial aspect of the distal left arm with two previous episodes of nephrotic syndrome. Multiple enlarged axillary lymph nodes and epitrochlear nodes were noted. Ultrasonography revealed a mixed echogenic mass with enlarged lymph nodes. MRI showed a heterogeneous hyperintense lesion. Image-guided fine-needle aspiration showed multiple lymphocytes and eosinophils suggestive of Kimura's disease. The swelling was surgically excised under general anaesthesia. Histopathology of the excised mass confirmed the diagnosis of Kimura's disease.
10.1136/bcr-2022-250758
Kimura's Disease.
Wang Xizhong,Ma Ying,Wang Zhiming
The Journal of craniofacial surgery
Kimura's disease (KD) is a benign, rare and chronic inflammatory disorder of unknown etiology and it affects subcutaneous tissues, lymph nodes, and salivary glands. The clinical manifestation of cases reported is mainly small neoplasms or enlarged lymph nodes, while cases for large masses are rarely reported. This case reveals a female patient of KD with large masses in the head and neck region. The scope of the tumor is huge, which seriously affects the facial shape and psychology of the patient, thereby affecting the daily life of the patient. Although the patient had surgically removed the same site tumor 8 years ago, it was not possible to determine whether it was a recurrent case because the postoperative pathological diagnosis of first treatment was not confirmed. Under the general anesthesia, the right head and neck masses were removed. During the operation, the facial nerve branches were wrapped by the masses. After consulting the family members, it was agreed that the facial nerve should not be preserved for maximum extent removal of the tumor. Although the patient has facial paralysis symptoms after surgery, the facial shape and patient's psychology are greatly improved, and the patient is satisfied with the treatment effect. Surgical treatment is one of the effective ways to treat huge tumors in the head and neck of KD. This study has certain guiding significance for clinicians to treat huge tumors of head and neck in KD.
10.1097/SCS.0000000000005430