Association between sleep duration and depression in US adults: A cross-sectional study. Dong Lu,Xie Yongwei,Zou Xiaohua Journal of affective disorders BACKGROUND:Evidence of an association between sleep duration and depression was inconsistent. METHODS:Adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2016 were included. Multivariable logistic regression was used to evaluate the association between sleep duration and depression. RESULTS:Among the 25,962 participants (mean age 48.1 years; 49.2% male) in this study, 23,636 had a depression score <10 and 2,326 had a depression score ≥ 10. After adjustment for gender, age, race/ethnicity, education, marital status, and annual family income, BMI, alcohol status, and smoking status, hypertension, diabetes, dyslipidemia, work activity, and physical activity risk factors, participants who had short sleep duration had odds ratios (OR) of 1.86 (95% confidence interval 1.59, 2.17) and participants who had long sleep duration had OR of 1.49 (95% confidence interval 1.22, 1.83) for incident depression. Further analysis revealed a U-shaped association between sleep duration and incident depression. When sleep duration < 8 hours, increased sleep duration is associated with a significantly lower risk of incident depression (OR = 0.68 [95% CI 0.64, 0.71], P < 0.001). When sleep duration ≥ 8 hours, the risk of depression increased significantly with an increase in sleep duration (OR = 1.32 [95%CI 1.23, 1.41], P < 0.001). CONCLUSIONS:Sleep duration were independently associated with a higher incident depression. Not only insufficient sleep but excessive sleep also increase the risk of depression. 10.1016/j.jad.2021.09.075

Association Between Abnormal Sleep Duration and Stroke in the United States. Neurology INTRODUCTION:The new American Heart Association Life's Essential 8 construct of ideal cardiovascular health now includes sleep duration. Little is known, however, about sleep duration in individuals with prior stroke. Our objective was to compare sleep duration among individuals with and without prior stroke. METHODS:Using the National Health and Nutrition Examination Surveys (NHANES) database (2005-2018), individuals 18 years or older were identified (n = 37,987 without self-reported stroke; n = 1,572 with self-reported stroke). Prevalence of normal sleep duration (7-8 or 6-8 hours/night because of multiple definitions in the literature) was compared between persons with and without self-reported history of stroke using the Rao-Scott χ test. Multinomial logistic regression analysis was used to evaluate the relationship between prior stroke and abnormal sleep before and after adjusting for demographic and clinical variables. RESULTS:Compared with individuals without stroke, those with prior stroke were more likely to report >8 hours/night (unadjusted odds ratio (OR) 2.03, 95% confidence interval (CI) 1.64-2.51), <7 hours/night (1.29, 1.08-1.53), and <6 hours/night (1.87, 1.53-2.29). After adjustment, these associations were attenuated (adjusted OR 1.54, 95% CI 1.22-1.94 and 1.15, 0.96-1.38 and 1.50, 1.21-1.85). DISCUSSION:US stroke survivors are more likely to have abnormal sleep duration than those without prior stroke. Limitations of this study include the cross-sectional and self-reported nature of the data. 10.1212/WNL.0000000000209807