BK virus infection in allogeneic hematopoietic cell transplantation: An update on pathogenesis, immune responses, diagnosis and treatments. Saade Anastasia,Styczynski Jan,Cesaro Simone, The Journal of infection In hematopoietic cell transplantation (HCT) patients, BK polyomavirus (BKPyV) infection results in significant morbidity mainly due to hemorrhagic cystitis (HC). Despite increased knowledge acquired over recent decades, no treatment has shown effectiveness in the management of organ damage in HCT allografts. This review summarizes the current knowledge on BKPyV, from the virus constitution to the pathophysiology and immune-related mechanisms. We next focus on BKPyV-induced HC in HCT to discuss the benefit of monitoring BKPyV viruria and viremia in the management of patients. At last, we review currently used therapeutics, along with future promising therapies to propose clinical and practical guidelines and further interesting research areas. 10.1016/j.jinf.2020.06.009

Evaluation and management of BK virus-associated nephropathy following allogeneic hematopoietic cell transplantation. Raval Mihir,Gulbis Alison,Bollard Catherine,Leen Ann,Chemaly Roy,Shpall Elizabeth,Lahoti Amit,Kebriaei Partow Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation BK virus nephropathy is a common cause of graft loss in kidney transplant recipients. Cases of BK nephropathy following allogeneic hematopoietic cell transplantation (HCT) are underreported. An increased incidence of BK virus-associated nephropathy is being seen in the setting of more profound and prolonged immunosuppression following solid organ transplantation and HCT. We will review diagnostic and treatment modalities for BK-associated nephropathy following allogeneic HCT. 10.1016/j.bbmt.2011.07.010