Perspective from NHANES data: synergistic effects of visceral adiposity index and lipid accumulation products on diabetes risk. Scientific reports This study aimed to explore the synergistic effect of lipid accumulation product (LAP) and visceral adiposity index (VAI) on diabetes risk, and to evaluate the potential associations of these novel metabolic markers with diabetes. The current cross-sectional survey utilised data from the 2015-2018 National Health and Nutrition Examination Survey (NHANES). The relationship between LAP and VAI levels and diabetes was examined using multiple logistic regression analysis. Moreover, threshold effects analysis and smoothed curve fitting were used as analytical techniques. The diabetes group exhibited significantly higher LAP (90.1 ± 84.1) and VAI (2.8 ± 2.8) levels compared to the non-diabetes group (p < 0.0001).After adjusting for confounding factors, LAP (OR = 1.01, 95% CI: 1.00-1.01, p < 0.0001) and VAI (OR = 1.22, 95% CI: 1.16-1.28, p < 0.0001) were independently associated with diabetes risk. The interaction term (LAP x VAI) showed a significant synergistic effect (OR = 1.01, 95% CI: 1.00-1.07, p = 0.0042).Diabetes risk significantly increased when LAP was below 97.70 (OR = 1.03, 95% CI: 1.02-1.03, p < 0.0001) and when VAI was below 3.76 (OR = 1.88, 95% CI: 1.69-2.08, p < 0.0001). According to this study, LAP and VAI are independent predictors of diabetes risk and exhibit a significant synergistic effect. Combining these indices may improve the accuracy of diabetes screening. 10.1038/s41598-024-84034-7

Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999-2000 NHANES cross-sectional study. Scientific reports Helicobacter pylori (H. pylori) infection is linked to metabolic syndrome and insulin resistance, with the triglyceride-glucose (TyG) index serving as a reliable marker for the latter. This study investigates the association between the TyG index and H. pylori infection. The study utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2000. Participants underwent serologic testing for H. pylori, and the TyG index was calculated from fasting laboratory measurements. Multivariate logistic regression and restricted cubic spline methods were used to assess the association and explore the dose-response relationship. The analysis included 2984 participants. Elevated TyG index values were associated with an increased likelihood of H. pylori infection. The risk of infection rose with higher TyG index quartiles, with the highest quartile showing the most significant increase (OR = 1.54, 95% CI: 1.15-2.07, P = 0.004). A linear relationship between the TyG index and H. pylori infection was demonstrated. The study findings indicate a significant positive association between the TyG index and H. pylori infection. This association highlights the importance of metabolic health in the context of H. pylori infection and suggests that further research is needed to explore the potential implications for health promotion strategies. 10.1038/s41598-024-84536-4

Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015-2020). Scientific reports Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response is an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and stroke. Methods We collected data on participants with SII and stroke from the 2015-2020 cycle of National Health and Nutrition Examination Survey (NHANES) for the cross-sectional investigation. Multivariate linear regression models were used to test the association between SII and stroke. Fitted smoothing curves and threshold effect analysis were applied to describe the nonlinear relationship. Results A total of 13,287 participants were included in our study, including 611 (4.598%) participants with stroke. In a multivariate linear regression analysis, we found a significant positive association between SII and stroke, and the odds ratio (OR) [95% CI] of SII associating with prevalence of stroke was [1.02 (1.01, 1.04)] (P < 0.01). In subgroup analysis and interaction experiments, we found that this positive relationship was not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes and coronary heart disease (P for trend > 0.05). Moreover, we found an nonlinear relationship between SII and stroke with an inflection point of 740 (1,000 cells /µl) by using a two-segment linear regression model. Conclusions This study implies that increased SII levels are linked to stroke. To confirm our findings, more large-scale prospective investigations are needed. 10.1038/s41598-024-83073-4

Association of sleep duration and sleep disorders with post-stroke depression and all-cause and cardiovascular disease mortality in US stroke survivors: results from NHANES 2005-2018. European journal of medical research BACKGROUND:Sleep disturbance is a common concern among stroke survivors, yet the association of sleep duration and sleep disorders with post-stroke depression and all-cause and cardiovascular disease (CVD) mortality remains elusive. We aimed to explore these associations using data from the National Health and Nutrition Examination Survey (NHANES). METHODS:Adult stroke survivors from NHANES 2005-2018 were included. Sleep information and stroke diagnoses were derived from self-reports on relevant questionnaires. Mortality data were collected by prospectively matching to the National Death Index. Multivariate logistic regression and Cox proportional hazards regression were used to explore these associations and calculate the odds ratio (OR) and hazard ratio (HR), respectively. RESULTS:A total of 1101 stroke participants were included. In the fully adjusted model, sleep disorders were associated with increased odds of post-stroke depression (OR 2.689, p = 0.0146). Sleep duration was inversely associated with the odds of post-stroke depression; compared to normal sleep duration, short sleep duration was associated with increased odds of post-stroke depression (OR 2.196, p = 0.0059), whereas long sleep duration was not (p = 0.1435). Sleep disorders were associated with CVD mortality (HR of 1.948, p = 0.026) but not all-cause mortality (p = 0.224) in stroke survivors. Sleep duration was positively associated with all-cause mortality in stroke survivors (HR 1.075, p = 0.042); however, neither short nor long sleep duration was associated with mortality compared to normal sleep duration. Restricted cubic spline modeling suggested that sleep duration was nonlinearly and linearly associated with post-stroke depression and all-cause mortality, respectively. Age influenced the association between sleep disorders and CVD mortality in stroke survivors. CONCLUSIONS:Sleep disorders and short sleep duration were associated with increased odds of post-stroke depression, whereas sleep disorders were associated with increased CVD mortality in stroke survivors. These findings underscore that achieving normal sleep duration and improving sleep disorders may reduce the odds of post-stroke depression and mortality. 10.1186/s40001-024-02227-2

Association between composite dietary antioxidant index and chronic obstructive pulmonary disease in adults: results of NHANES 2015-2020 and mendelian randomization study. The British journal of nutrition Oxidative stress is present in chronic obstructive pulmonary disease (COPD); however, the effect of increased dietary antioxidants on reducing COPD risk remains unclear. The aim of this study was to investigate the association of the Composite Dietary Antioxidant Index (CDAI) with COPD in adults. This study conducted a cross-sectional investigation using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2015 to March 2020 to explore the association between CDAI and COPD in adults. This study included 9295 participants. Three logistic regression models (crude model, partially adjusted model, and fully adjusted model) and restricted cubic spline (RCS) curves were utilized to assess the association between CDAI levels and COPD risk. Subsequently, a two-sample Mendelian Randomization (MR) was employed to analyze the causal impact of antioxidant levels within CDAI on the occurrence of COPD. CDAI levels were inversely associated with COPD after adjusting for confounders (OR=0.97, 95%CI:0.95-1.00), and the association was linear (p<0.001), and the results of the RCS showed that CDAI was linearly correlated with COPD occurrence (p<0.001). MR analysis revealed a causal relationship between vitamin C and COPD occurrence (OR=0.99, 95%CI:0.98-1.00, p<0.05). Our study indicates that dietary sources of antioxidants may reduce the risk of COPD occurrence, and the results of the MR analysis further show that vitamin C is causally associated with a reduced risk of COPD occurrence. However, further exploration is needed to understand how antioxidants prevent COPD. 10.1017/S0007114524003349