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    Establishing an Animal Model of Single-Sided Deafness in . Banakis Hartl Renee M,Greene Nathaniel T,Benichoux Victor,Dondzillo Anna,Brown Andrew D,Tollin Daniel J Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery OBJECTIVES:(1) To characterize changes in brainstem neural activity following unilateral deafening in an animal model. (2) To compare brainstem neural activity from unilaterally deafened animals with that of normal-hearing controls. STUDY DESIGN:Prospective controlled animal study. SETTING:Vivarium and animal research facilities. SUBJECTS AND METHODS:The effect of single-sided deafness on brainstem activity was studied in . Animals were unilaterally deafened via gentamycin injection into the middle ear, which was verified by loss of auditory brainstem responses (ABRs). Animals underwent measurement of ABR and local field potential in the inferior colliculus. RESULTS:Four animals underwent chemical deafening, with 2 normal-hearing animals as controls. ABRs confirmed unilateral loss of auditory function. Deafened animals demonstrated symmetric local field potential responses that were distinctly different than the contralaterally dominated responses of the inferior colliculus seen in normal-hearing animals. CONCLUSION:We successfully developed a model for unilateral deafness to investigate effects of single-sided deafness on brainstem plasticity. This preliminary investigation serves as a foundation for more comprehensive studies that will include cochlear implantation and manipulation of binaural cues, as well as functional behavioral tests. 10.1177/0194599819877649
    Efficacy of combination therapy in adolescent and adult patients with total-deafness sudden sensorineural hearing loss. Sun Hongcun,Hu Jiandao,Mao Zhenyu,Ma ZhaoXin Acta oto-laryngologica BACKGROUND:Combination therapy is the first-line option for total-deafness sudden sensorineural hearing loss (SSNHL). Age may act as a crucial prognostic factor. OBJECTIVE:The aim of this study was to compare efficacy of combination therapy between adolescent and adult patients with total-deafness SSNHL. MATERIALS AND METHODS:Twenty-five adolescent patients (adolescent group) and 106 adult patients (adult group) with total-deafness SSNHL were recruited. All the recruited patients underwent initial treatment with batroxobin, methylprednisolone, and gastrodin. After 10-day treatment, hearing outcomes were determined by pure-tone average measured by audiometry. Moreover, the total effective rates in the hearing recovery and improvement of tinnitus were calculated. RESULTS:There existed no significant difference between two groups in the total effective rate of the hearing recovery (p = .110). However, a significant difference was found in the total effective rate of improvement of tinnitus between two groups (p = .016). Both adolescent and adult patients could receive the optimal hearing gains at 500 Hz (20.2 ± 13.3 and 23.1 ± 13.9dB, respectively), followed by those at 1000 Hz (18.8 ± 12.5 and 22.7 ± 14.8dB, respectively). Yet, adult patients could get better hearing gains only at 500 Hz than adolescent patients (p = .02). CONCLUSION:Compared with adult patients, adolescent patients with total-deafness SSNHL undergoing combination therapy may be less likely to have hearing recovery and the improvement of tinnitus. 10.1080/00016489.2018.1554266
    Clinical characteristics of cerebral hemorrhage with bilateral sudden deafness as the first symptom. Deng Yan,Shi Jin,Zhang Ming,Qi Xueliang Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology OBJECTIVE:To summarize and analyze the clinical data of 12 Chinese patients of cerebral hemorrhage with bilateral sudden deafness as the first symptom and to explore the relationship between cerebral hemorrhage and bilateral sudden deafness. METHODS:Retrospective analysis of clinical data of patients, including age, clinical manifestations, location of cerebral hemorrhage, hearing loss, and recovery. RESULTS:The average age of onset in 12 patients was 53.92 years, 9 had a history of hypertension, 7 had a history of stroke, and 6 had typical stroke symptoms. There were 7 cases of basal ganglia hemorrhage; 2 cases of cerebellum hemorrhage; and 1 case of pontine hemorrhage, temporal lobe hemorrhage, and thalamus infarction. The auditory brainstem evoked potential test results of 3 patients were normal, and 5 of 6 patients who completed pure tone audiometry had hearing impairment. Five out of 9 patients had basically or completely recovered hearing. CONCLUSION:The results showed that patients were mostly middle-aged and elderly with no typical stroke symptoms, and a history of stroke and hypertension increased the risk of hearing loss. The cause of hearing loss in patients with cerebral hemorrhage may be related to the damage of the hearing conduction pathway or (and) the lack of blood supply to the central auditory nervous system. Detecting hearing impairment in time and actively intervening can help most patients to improve their hearing significantly. The degree of hearing damage and recovery is related to the bleeding site, the amount of bleeding, and the timely treatment. 10.1007/s10072-020-04515-1
    Declining prevalence of pediatric sudden deafness during the past two decades. Zhang Bang-Yan,Young Yi-Ho International journal of pediatric otorhinolaryngology OBJECTIVE:This study compared the prevalence of sudden deafness (SD) in children to investigate the evolution of pediatric SD during the past two decades. METHODS:From 1996 to 2005, totaling 358 SD patients were experienced. Of them, 25 patients (7%) aged <15 years were assigned to Group A. In contrast, 5 patients (2%) aged <15 years of 242 SD patients encountered during the period 2006-2015 were assigned to Group B. All patients underwent audiovestibular function testing. RESULTS:The measles-mumps-rubella (MMR) vaccination reached to 95% vaccination rate in Taiwan after 1994. As 1994 (MMR vaccination years) + 11 (mean age of pediatric SD) equals 2005, this study found that declining prevalence of pediatric SD was from 7% (1996-2005) to 2% (2006-2015) at our hospital, consistent with declining annual cases of SD in Taiwan during the past decades. A significantly higher abnormality rate of mean hearing level (93%) than abnormal caloric responses (20%) was identified indicating that pediatric SD predominately affected the cochlear partition. CONCLUSION:The prevalence of pediatric SD cases has significantly declined during the past 20 years, probably due to global vaccination policy. Other causal factors such as growing numbers of hospital and advancement in radiological diagnostic technique may also contribute to the declining prevalence. 10.1016/j.ijporl.2019.01.029
    Correlation between effectual time and the curative effect in patients with all frequency descending sudden deafness after treatment. Si Jian-Ping,Jiang Hong,Li Yan-Yan American journal of otolaryngology OBJECTIVE:To discuss the correlation between effectual time and the curative effect in patients with all frequency descending sudden deafness. METHODS:According to effectual time, the subjects were divided into first week effectual group and second week effectual group and the curative effect of each group was compared. RESULTS:In patients with flat descent sudden deafness, the curative rate of the first week effectual group was higher than that of the second week effectual group, but there was no significant difference between the two groups (χ = 1.584, P = 0.208). Meanwhile, the total significant effective rate of the first week effectual group was higher than that of the second week effectual group, without obvious difference between the two groups (χ = 0.227, P = 0.634). Furthermore, in patients with total deafness type of sudden deafness, the curative rate of the first week effectual group was higher than that of the second week effectual group, showing no remarkable difference between the two groups (χ = 2.726, P = 0.099). Besides, there was no remarkable difference in the comparison of the total significant effective rate (χ = 2.933, P = 0.087), which was higher in the first week effectual group than that in the second week effectual group. CONCLUSION:The course of treatment should be at least 2 weeks in patients with all frequency descending sudden deafness after onset. 10.1016/j.amjoto.2020.102621