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    Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France. Alberts Catharina J,Heard Isabelle,Canestri Ana,Marchand Lucie,Fléjou Jean-François,Piroth Lionel,Ferry Tristan,Didelot Jean-Michel,Siproudhis Laurent,Henno Sébastien,Poizot-Martin Isabelle,Darragh Teresa M,Clifford Gary M,Combes Jean-Damien,Etienney Isabelle, The Journal of infectious diseases BACKGROUND:Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS:We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). RESULTS:Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). CONCLUSIONS:In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions. 10.1093/infdis/jiz623