Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.
Choi Soyeon,Kim Ji Hye,Kim Kyungbin,Kim Misung,Choi Hye Jeong,Kim Young Min,Suh Jae Hee,Seo Min Jung,Cha Hee Jeong
Journal of pathology and translational medicine
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), is one of the specific type of low-grade B-cell lymphoma not infrequently found worldwide. It typically involves mucosal sites such as stomach and conjunctiva; however, primary hepatic MALT lymphoma has been extremely rarely reported. We describe a case of hepatic MALT lymphoma in a 70-year-old male patient who underwent left hepatectomy due to the incidentally detected liver masses at a medical checkup. The resected specimen revealed multinodular masses consisting of small-to-intermediate-sized lymphoid cells with serpentine pattern and focal lymphoepithelial lesions. The tumor cells were diffusely positive for CD20 and Bcl-2 but negative for CD3, CD10, CD5, CD23, CD43, and cyclinD1. The Ki-67 labeling index was 10% and immunoglobulin heavy chain gene rearrangement study confirmed monoclonal proliferation. In this paper, we discuss several unique clinicopathologic characteristics which will be helpful to the differential diagnosis of hepatic MALT lymphoma.
[Two Cases of Primary Hepatic Mucosa-Associated Lymphoid Tissue(MALT) Lymphoma].
Fujiwara Yasuhiro,Sakamoto Kazuhiko,Tokuhisa Yoshihiro,Tokumitsu Yukio,Nakajima Masao,Matsukuma Satoru,Matsui Hiroto,Shindo Yoshitaro,Kanekiyo Shinsuke,Suzuki Nobuaki,Takeda Shigeru,Ueno Tomio,Yoshino Shigefumi,Hazama Shoichi,Nagano Hiroaki
Gan to kagaku ryoho. Cancer & chemotherapy
Case 1: A 57-year-old woman with chronic hepatitis related to the hepatitis B virus was found to have a liver tumor on ultrasonography(US). Computed tomography(CT), magnetic resonance imaging(MRI), and angiography revealed 2 tumors in the liver. The patient underwent right anterior sectorectomy, and histopathologic analysis revealed mucosa-associated lymphoid tissue(MALT)lymphoma. Thirty months later, recurrence was confirmed using liver biopsy. CR was confirmed after radiation and chemotherapy, and the patient has survived. Case 2: A 71-year-old woman came to our hospital for rheumatism treatment. US, CT, and MRI revealed a tumor in the left lateral segment of the liver. The patient underwent laparoscopic partial liver resection and histopathologic analysis revealed MALT lymphoma. The patient has survived.