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    Sepsis and Septic Shock - Basics of diagnosis, pathophysiology and clinical decision making. Font Michael D,Thyagarajan Braghadheeswar,Khanna Ashish K The Medical clinics of North America Sepsis and septic shock are major causes of mortality among hospitalized patients. The sepsis state is due to dysregulated host response to infection, leading to inflammatory damage to nearly every organ system. Early recognition of sepsis and appropriate treatment with antibiotics, fluids, and vasopressors is essential to reducing organ system injury and mortality. This review summarizes the current understanding of the epidemiology, pathophysiology, diagnosis, and treatment of sepsis and septic shock. 10.1016/j.mcna.2020.02.011