加载中

    Accurate Classification of Diminutive Colorectal Polyps Using Computer-Aided Analysis. Chen Peng-Jen,Lin Meng-Chiung,Lai Mei-Ju,Lin Jung-Chun,Lu Henry Horng-Shing,Tseng Vincent S Gastroenterology BACKGROUND & AIMS:Narrow-band imaging is an image-enhanced form of endoscopy used to observed microstructures and capillaries of the mucosal epithelium which allows for real-time prediction of histologic features of colorectal polyps. However, narrow-band imaging expertise is required to differentiate hyperplastic from neoplastic polyps with high levels of accuracy. We developed and tested a system of computer-aided diagnosis with a deep neural network (DNN-CAD) to analyze narrow-band images of diminutive colorectal polyps. METHODS:We collected 1476 images of neoplastic polyps and 681 images of hyperplastic polyps, obtained from the picture archiving and communications system database in a tertiary hospital in Taiwan. Histologic findings from the polyps were also collected and used as the reference standard. The images and data were used to train the DNN. A test set of images (96 hyperplastic and 188 neoplastic polyps, smaller than 5 mm), obtained from patients who underwent colonoscopies from March 2017 through August 2017, was then used to test the diagnostic ability of the DNN-CAD vs endoscopists (2 expert and 4 novice), who were asked to classify the images of the test set as neoplastic or hyperplastic. Their classifications were compared with findings from histologic analysis. The primary outcome measures were diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic time. The accuracy, sensitivity, specificity, PPV, NPV, and diagnostic time were compared among DNN-CAD, the novice endoscopists, and the expert endoscopists. The study was designed to detect a difference of 10% in accuracy by a 2-sided McNemar test. RESULTS:In the test set, the DNN-CAD identified neoplastic or hyperplastic polyps with 96.3% sensitivity, 78.1% specificity, a PPV of 89.6%, and a NPV of 91.5%. Fewer than half of the novice endoscopists classified polyps with a NPV of 90% (their NPVs ranged from 73.9% to 84.0%). DNN-CAD classified polyps as neoplastic or hyperplastic in 0.45 ± 0.07 seconds-shorter than the time required by experts (1.54 ± 1.30 seconds) and nonexperts (1.77 ± 1.37 seconds) (both P < .001). DNN-CAD classified polyps with perfect intra-observer agreement (kappa score of 1). There was a low level of intra-observer and inter-observer agreement in classification among endoscopists. CONCLUSIONS:We developed a system called DNN-CAD to identify neoplastic or hyperplastic colorectal polyps less than 5 mm. The system classified polyps with a PPV of 89.6%, and a NPV of 91.5%, and in a shorter time than endoscopists. This deep-learning model has potential for not only endoscopic image recognition but for other forms of medical image analysis, including sonography, computed tomography, and magnetic resonance images. 10.1053/j.gastro.2017.10.010
    Development and validation of a deep-learning algorithm for the detection of polyps during colonoscopy. Wang Pu,Xiao Xiao,Glissen Brown Jeremy R,Berzin Tyler M,Tu Mengtian,Xiong Fei,Hu Xiao,Liu Peixi,Song Yan,Zhang Di,Yang Xue,Li Liangping,He Jiong,Yi Xin,Liu Jingjia,Liu Xiaogang Nature biomedical engineering The detection and removal of precancerous polyps via colonoscopy is the gold standard for the prevention of colon cancer. However, the detection rate of adenomatous polyps can vary significantly among endoscopists. Here, we show that a machine-learning algorithm can detect polyps in clinical colonoscopies, in real time and with high sensitivity and specificity. We developed the deep-learning algorithm by using data from 1,290 patients, and validated it on newly collected 27,113 colonoscopy images from 1,138 patients with at least one detected polyp (per-image-sensitivity, 94.38%; per-image-specificity, 95.92%; area under the receiver operating characteristic curve, 0.984), on a public database of 612 polyp-containing images (per-image-sensitivity, 88.24%), on 138 colonoscopy videos with histologically confirmed polyps (per-image-sensitivity of 91.64%; per-polyp-sensitivity, 100%), and on 54 unaltered full-range colonoscopy videos without polyps (per-image-specificity, 95.40%). By using a multi-threaded processing system, the algorithm can process at least 25 frames per second with a latency of 76.80 ± 5.60 ms in real-time video analysis. The software may aid endoscopists while performing colonoscopies, and help assess differences in polyp and adenoma detection performance among endoscopists. 10.1038/s41551-018-0301-3
    Artificial Intelligence-Assisted Polyp Detection for Colonoscopy: Initial Experience. Misawa Masashi,Kudo Shin-Ei,Mori Yuichi,Cho Tomonari,Kataoka Shinichi,Yamauchi Akihiro,Ogawa Yushi,Maeda Yasuharu,Takeda Kenichi,Ichimasa Katsuro,Nakamura Hiroki,Yagawa Yusuke,Toyoshima Naoya,Ogata Noriyuki,Kudo Toyoki,Hisayuki Tomokazu,Hayashi Takemasa,Wakamura Kunihiko,Baba Toshiyuki,Ishida Fumio,Itoh Hayato,Roth Holger,Oda Masahiro,Mori Kensaku Gastroenterology 10.1053/j.gastro.2018.04.003