Shift work and incidence of dementia: A Danish Nurse Cohort study. Jørgensen Jeanette Therming,Hansen Johnni,Westendorp Rudi G J,Nabe-Nielsen Kirsten,Stayner Leslie Thomas,Simonsen Mette Kildevaeld,Andersen Zorana Jovanovic Alzheimer's & dementia : the journal of the Alzheimer's Association INTRODUCTION:A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS:We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS:Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). DISCUSSION:Persistent night shift work may increase the risk of dementia. 10.1002/alz.12126