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    Prophylactic and Therapeutic Efficacy of Prebiotic Supplementation against Intestinal Coccidiosis in Rabbits. El-Ashram Saeed A,Aboelhadid Shawky M,Abdel-Kafy El-Sayed M,Hashem Shymaa A,Mahrous Lilian N,Farghly Eman M,Moawad Usama K,Kamel Asmaa A Animals : an open access journal from MDPI This study was conducted to investigate the effect of prebiotic supplementation against intestinal coccidiosis in rabbits. Fifty male rabbits aged 35-60 days (1-1.5 kg) were divided into prophylactic and therapeutic experiments (five groups, 10 rabbits per group). Prophylactic experiment had prebiotic supplemented (PS-P), non-supplemented infected control (NI-P), and non-supplemented non-infected control (NN-P) groups. Ten days post-prebiotic supplementation (PPS), rabbits in groups PS-P and NI-P were infected orally with 5.0 × 10 sporulated oocysts of mixed species. However, therapeutic experiment had prebiotic supplemented (PS-T) and untreated infected (UI-T) groups of naturally infected rabbits with species. A significant reduction in oocyst count per gram feces (OPG) ( ≤ 0.05) was reported in the PS-P (57.33 × 10 ± 2.84) and NI-P (130.83 × 10 ± 43.38) groups during the experiment. Additionally, rabbits in groups (PS-P, 970.33 ± 31.79 g and NI-P, 870.66 ± 6.66 g) showed weight loss after infection. However, a significant ( ≤ 0.05) decrease in OPG was observed at day seven PPS in the PS-T group (4 × 10 ± 0.00) when compared with the UI-T group (32 × 10 ± 7.54). Furthermore, the PS-T group had a higher body weight than rabbits in the UI-T group. Histopathological findings of the intestinal tissues (duodenum, jejunum, and ileum) showed that the counts of the endogenous stages were significantly higher in the NI-P and UI-T groups than in the prebiotic-supplemented groups (PS-P and PS-T). Supplementation of the prebiotic did not have any adverse effects on biochemical parameters, such as AST, ALT, creatinine, total protein, and total cholesterol. In conclusion, prebiotic supplementation can be used to minimize the adverse effects of intestinal coccidiosis in rabbits, which in turn limits body weight loss, especially for the prophylaxis of coccidial infection. 10.3390/ani9110965