Serum level of interleukin-22 in patients with cutaneous warts: A case-control study. Journal of cosmetic dermatology BACKGROUND:Warts are viral cutaneous infections caused by human papilloma virus (HPV), presented by verrucous growth over the skin surface. The immune response is considered to play a crucial role in HPV clearance. It depends on intact cellular immunity including natural killer (NK) cell and cytotoxic T cells. It has been clarified that T-helper (Th) 1 cytokines (interleukin (IL)-2, interferon-γ, and tumor necrosis factor-a) and IL-17 are involved in HPV clearance. IL-22 is one of IL-10 family of cytokines produced by NK cells, Th1, Th17, and Th22 cells. In the skin, IL-22 reduces keratinocyte cornification and enhances keratinocyte production of antimicrobial peptides. IL-22 overexpression has been demonstrated in various viral infections and skin inflammatory disorders. AIM:The aim of this study was to assess serum levels of IL-22 in patients with warts and its association with their different clinical characteristics. METHODS:The study included 20 patients with warts and 20 control subjects. Serum concentration of IL-22 was measured by enzyme-linked immune sorbent assay. RESULTS:Serum levels of IL-22 were significantly higher in patients with warts than in control subjects (P < .001). The levels were significantly higher in patients with recurrent warts after prior treatment than in patients with first-time warts (P = .007). Moreover, a significant positive correlation was detected between serum levels of IL-22 and the number of warts (P = .017). CONCLUSION:Serum level of IL-22 was elevated in patients with warts. Thus, IL-22 may have a crucial role in the antiviral immune response against this infection. 10.1111/jocd.13779

Buschke-Lowenstein tumor and pregnancy: a case report. Crespo R,Puig F,Lanzon A,Borell A European journal of gynaecological oncology Buschke-Lowenstein tumor is a giant condyloma acuminatum that arises on the male and female anogenital region. It is considered a histologically benign tumor but carries a risk of malignant transformation. Early diagnosis and treatment are advised and the choice of treatment is crucial. We present a case of a 31-year-old pregnant woman with myasthenia gravis affected by Buschke-Lowenstein tumor.

[Association of giant condyloma acuminatum of the penis with intraurethral simple condylomata. Apropos of a case]. Gonzalvo Pérez V,Eres Saez F J,Ramada Benlloch F J,Navalón Verdejo P,Millán Parilla F,Sánchez Carazo J L,Illueca Ferrer E,Zaragoza Orts J Archivos espanoles de urologia We report on an HIV-positive male patient with a giant condyloma acuminatum at the base of penis coexisting with simple intraurethral condylomas and no crown lesions. The association of both processes indicate the likelihood of a common viral etiology. The presentation of this florid picture in a terminal patient with AIDS indicates that urologists are likely to find an increased incidence of this condition in the forthcoming years.