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共4篇 平均IF=6.85 (1.8-26.8)更多分析
  • 2区Q1影响因子: 5.6
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    1. Multifunctional drug nanocarriers formed by cRGD-conjugated βCD-PAMAM-PEG for targeted cancer therapy.
    期刊:Colloids and surfaces. B, Biointerfaces
    日期:2015-01-03
    DOI :10.1016/j.colsurfb.2014.12.042
    Polyamidoamine (PAMAM) dendrimer was conjugated with both carboxymethyl-β-cyclodextrin (βCD) and poly(ethylene glycol) (PEG). Cyclic RGD peptide, used as a tumor targeting ligand, was then selectively conjugated onto the distal ends of the PEG arms. The resulting βCD-PAMAM-PEG-cRGD polymer was able to form stable and uniform nanoparticles (NPs) in aqueous solution. Doxorubicin (Dox), a model hydrophobic anticancer drug, was effectively encapsulated in the NPs via an inclusion complex formed between the drug and βCD. The Dox loading level was 16.8 wt%. The cellular uptake of cRGD-conjugated Dox-loaded NPs in the U87MG cell line was much higher than that of non-targeted NPs. Furthermore, the anti-proliferative effect of the cRGD-conjugated NPs was superior to that of free drug and non-targeted NPs. These results suggest that NPs formed by βCD-PAMAM-PEG-cRGD with a high drug payload may significantly improve the anticancer efficacy by tumor-targeted delivery and enhanced cellular uptake.
  • 1区Q1影响因子: 26.8
    2. RGD-modified PEG-PAMAM-DOX conjugate: in vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor cells.
    作者:Zhu Saijie , Qian Lili , Hong Minghuang , Zhang Lihong , Pei Yuanying , Jiang Yanyan
    期刊:Advanced materials (Deerfield Beach, Fla.)
    日期:2011-03-01
    DOI :10.1002/adma.201003944
  • 2区Q1影响因子: 8.1
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    3. A novel dendrimer-based complex co-modified with cyclic RGD hexapeptide and penetratin for noninvasive targeting and penetration of the ocular posterior segment.
    作者:Yang Xiucheng , Wang Lihua , Li Lin , Han Meishan , Tang Shengnan , Wang Tengteng , Han Junping , He Xiaoyan , He Xiuting , Wang Aiping , Sun Kaoxiang
    期刊:Drug delivery
    日期:2019-12-01
    DOI :10.1080/10717544.2019.1667455
    Noninvasive drug delivery is a promising treatment strategy for ocular posterior segment diseases. Many physiological and anatomical barriers of the eye considerably restrict effective diffusion of therapeutics to the target site. To overcome this problem, a novel cyclic arginine-glycine-aspartate (RGD) hexapeptide and penetratin (PEN) co-modified PEGylation polyamidoamine (PAMAM) was designed as a nanocarriers (NCs), and its penetrating and targeting abilities were evaluated. In this study, we show that PAMAM-PEG (reaction molar ratio 1:32) has a relatively high grafting efficiency and low cytotoxicity. The particle size was within the range of 15-20 nm after modification with RGD and PEN. Cellular uptake of RGD-modified NCs involved significant affinity toward integrin αvβ3, which validated the targeting of neovasculature. An in vitro permeation study indicated that modification with PEN significantly improved penetration of the NCs (1.5 times higher). In vivo ocular distribution studies showed that, the NCs (modified with PEN or co-modified with RGD and PEN) were highly distributed in the cornea and retina ( < .001), and modification extended retinal retention time for more than 12 h. Therefore, these NCs appear to be a promising noninvasive ocular drug delivery system for ocular posterior segment diseases.
  • 4区Q3影响因子: 1.8
    4. Assessment of Lu-labeled carboxyl-terminated polyamidoamine (PAMAM) dendrimer-RGD peptide conjugate.
    作者:Vats Kusum , Sharma Rohit , Sharma Amit Kumar , Sarma Haladhar D , Satpati Drishty
    期刊:Journal of peptide science : an official publication of the European Peptide Society
    日期:2021-08-30
    DOI :10.1002/psc.3366
    Structurally unique polyamidoamine (PAMAM) dendrimers implanted with targeting biological moiety along with complexed radiometal constitute a favorable nano-system for diagnosis and therapy of targeted tumor sites. In the present study, carboxyl functionalities of PAMAM- generation 4 dendrimer (PAMAM-G4-COOH) were conjugated with ε-amino group of lysine of cRGDfK peptide to impart integrin α β targeting capability. Reaction of p-NH -Bn-DOTA with PAMAM was accomplished via acid-amine coupling using EDC/NHS for Lu-complexation. Lu-labeled nano-system, Lu-PAMAM-DOTA-cRGDfK demonstrated receptor-mediated uptake in murine melanoma B16F10 cells during in vitro cell uptake studies. In vivo biodistribution studies demonstrated low tumor uptake and retention of Lu-PAMAM-DOTA-cRGDfK which may be attributed to rapid blood clearance. However, fast clearance from non-target organs resulted in higher target to background ratio. Tumor uptake of targeted nano-system, Lu-PAMAM-DOTA-cRGDfK was observed to be significantly (p < 0.05) higher in comparison to Lu-PAMAM-DOTA without the targeting peptide. Inhibition studies with unlabeled cRGDfK resulted in 60% reduction in tumor uptake of Lu-PAMAM-DOTA-cRGDfK, indicating specificity of the developed nano-system towards integrin α β receptors.
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