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    [Comparative analysis of serum glutamate and gamma-aminobutyric acid levels in patients with bipolar depressive disorder and major depression disorder]. Liao J W,Wang S S,Yang H H,Ma P,Li C R,Pan J Y Zhonghua yi xue za zhi To investigate the difference of serum glutamate (Glu) and gamma- aminobutyric acid (GABA) levels between depressive patients and bipolar disorder patients with depressive episodes. From May 2018 to March 2019, forty-seven patients with depression (depression group) and 45 patients with bipolar depressive episode (bipolar depression group) were selected from the department of psychiatry, the First Affiliated Hospital of Jinan University, and 41 healthy controls (healthy control group) were simultaneously recruited from the community. The subjects' depression and anxiety were assessed by 17 items of Hamilton depression scale (HAMD-17) and Hamilton Anxiety Scale (HAMA). The serum levels of Glu, GABA and Glu decarboxylase (GAD) were detected by enzyme-linked immunosorbent assay (ELISA) . The serum Glu level ( (36±7) mg/L, (37±7) mg/L vs (28±4) mg/L, 10.97, 0.01) and Glu/GABA ratio (5.77±0.35, 8.18±0.24 vs 3.35±0.33, 37.68, 0.01) in depression and bipolar depression groups were higher than those of healthy control group, while the GABA level ((6.1±0.7) μmol/L,(4.1±0.8) μmol/L vs (8.1±1.2) μmol/L, 21.61, 0.01) and GAD ((31±6) U/L, (31±6) U/L vs (35±6) U/L, 5.61, 0.01) were lower than those of healthy control group. The level of serum GABA in bipolar depression group was lower than that in depression group. However, Glu/GABA was higher in bipolar depression group than that in depression group (0.01). The level of serum GABA in depression group was negatively correlated with HAMD sleep disorder factor (-0.46, 0.01). Both depression and bipolar depression have abnormal levels of Glu, GABA neurotransmitters and imbalance between Glu and GABA in peripheral blood circulation. Moreover, these abnormalities are more obvious in patients with bipolar depression. 10.3760/cma.j.cn112137-20191025-02319