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    Efficacy and Safety of a New Cosmeceutical Regimen Based on the Combination of Snail Secretion Filtrate and Snail Egg Extract to Improve Signs of Skin Aging. Lim Vanessa Ziying,Yong Angeline Anning,Tan Wee Ping Melissa,Zhao Xiahong,Vitale Maria,Goh Chee Leok The Journal of clinical and aesthetic dermatology Two extracts derived from the gastropod have been shown to have dermal regeneration properties: SCA® (secretion filtrate) with fibroblast growth factor-like activity and IFC®-CAF (cellular activating factor), a snail egg extract with skin stem cell activation activity. The objectives of this study were to evaluate the synergic antiaging activity and tolerability of SCA and IFC-CAF in a combined regimen compared to vehicle as a placebo control. A three-month, single-center, double-blinded, randomized, vehicle-controlled trial assessed the effects of a daily skincare routine divided into two treatment phases, as follows: intensive (1 month) and maintenance (2 months). Fifty women, aged 45-65 years, with signs of photoaging were randomized to receive either the active ingredients (n=30) or vehicle (n=20). Clinical evaluations included objective measurements of barrier function and skin hydration, elasticity, and color/brightness. Subjective assessments were conducted according to the Rao-Goldman and Glogau scales for wrinkles, the Patient Global Assessment (PGA) scale and Investigator Global Assessment (IGA) scale. Subjects in the active treatment group experienced reductions in transepidermal water loss and significant improvements in skin roughness, firmness, and elasticity. Both groups showed significant improvements in fine lines and wrinkles. PGA and IGA assessments indicated greater improvement in the active treatment group. The active snail extract treatment appears to be effective in improving signs of skin aging in women 45 to 65 years old. Larger randomized, controlled studies are needed to confirm our results.
    Human health and snails. Dhiman Varun,Pant Deepak Journal of immunoassay & immunochemistry Snails can provide a considerable variety of bioactive compounds for cosmetic and pharmaceutical industries, useful for the development of new formulations with less toxicity and post effects compared to regular compounds used for the purpose. Compounds from crude extract, mucus, slime consist of glycans, polypeptides, proteins, etc., and can be used for curing diseases like viral lesions, warts, and different dermal problems. Some particular uses of snails involve treating post-traumatic stress. Micro RNA of , was known to be responsible for the development of long-term memory and treatment of Alzheimer's and Dementia like diseases. This review explores the application of various bioactive compounds from snails with its potential as new translational medicinal and cosmetic applications. Snail bioactive compounds like ω-MVIIA, μ-SIIIA, μO-MrVIB, Xen2174, δ-EVIA, α-Vc1.1, σ-GVIIA, Conantokin-G, and Contulakin-G, conopeptides can be used for the development of anti-cancer drugs. These compounds target the innate immunity and improve the defense system of humans and provide protection against these life-threatening health concerns. FDA: Food and Drug Administration; UTI: urinal tract infection; nAChRs: nicotinic acetylcholine receptors; NMDA: N-methyl-D-aspartate; CNS: central nervous system; CAR T: chimeric antigen receptors therapy; Micro RNA: micro ribonucleic acid. 10.1080/15321819.2020.1844751
    Novel drug-loaded film forming patch based on gelatin and snail slime. Di Filippo Maria Francesca,Albertini Beatrice,Dolci Luisa Stella,Bonvicini Francesca,Bigi Adriana,Gentilomi Giovanna Angela,Passerini Nadia,Panzavolta Silvia International journal of pharmaceutics Gelatin-based films enriched with snail slime are proposed as novel biodegradable and naturally bioadhesive patches for cutaneous drug delivery. Films (thickness range 163-248 μm) were stretchable and they adhered firmly onto the wetted skin, especially those with high amount (70% V/V) of snail slime extract. Fluconazole was selected as model drug and added to films containing the highest amount of snail slime. The presence of Fluconazole (4.53 ± 0.07% w/w) did not modify significantly the mechanical properties, the swelling degree and the bioadhesive performances of the films. Structural investigations demonstrated that the crystalline form III of the drug changed to the amorphous one, forming an amorphous solid dispersion. Moreover, snail slime prevented the drug recrystallization over time. In vitro permeation studies showed that film exhibited a cumulative drug concentration (over 60% in 24 h) similar to that of the control solution containing 20% w/V of ethanol. Fluconazole-loaded gelatin films proved to be effective towards clinical isolates of Candida spp. indicating that the drug maintained its remarkable antifungal activity once formulated into gelatin and snail slime-based films. In conclusion, snail slime, thanks to its peculiar composition, has proved to be responsible of optimal skin adhesion, film flexibility and of the formation of a supersaturating drug delivery system able to increase skin permeation. 10.1016/j.ijpharm.2021.120408
    Biomolecules from snail mucus (Helix aspersa) conjugated gold nanoparticles, exhibiting potential wound healing and anti-inflammatory activity. Gubitosa Jennifer,Rizzi Vito,Fini Paola,Laurenzana Anna,Fibbi Gabriella,Veiga-Villauriz Clara,Fanelli Fiorenza,Fracassi Francesco,Onzo Alberto,Bianco Giuliana,Gaeta Carmine,Guerrieri Antonio,Cosma Pinalysa Soft matter In this work, for the first time, snail slime from garden snails "Helix Aspersa Müller", has been used to induce the formation of eco-friendly gold nanoparticles (AuNPs-SS) suitable for biomedical applications. An AuNPs-SS comprehensive investigation was performed and AuNPs with an average particle size of 14 ± 6 nm were observed, stabilized by a slime snail-based organic layer. Indeed, as recognized in high-resolution MALDI-MS analyses, and corroborated by FESEM, UV-Vis, ATR-FTIR, and XPS results, it was possible to assess the main presence of peptides and amino acids as the main components of the slime, that, combined with the AuNPs confers on them interesting properties. More specifically, we tested, in vitro, the AuNPs-SS safety in human keratinocytes and their potential effect on wound healing as well as their anti-inflammatory properties in murine macrophages. Moreover, the AuNPs-SS treatment resulted in a significant increase of the urokinase-type plasminogen activator receptor (uPAR), essential for keratinocyte adhesion, spreading, and migration, together with the reduction of LPS-induced IL1-β and IL-6 cytokine levels, and completely abrogated the synthesis of inducible nitric oxide synthase (iNOS). 10.1039/d0sm01638a
    A novel cysteine-rich antimicrobial peptide from the mucus of the snail of Achatina fulica. Zhong Jian,Wang Wenhong,Yang Xiaomei,Yan Xiuwen,Liu Rui Peptides Antimicrobial peptides (AMPs) are important components of the innate immunity. Many antimicrobial peptides have been found from marine mollusks. Little information about AMPs of mollusks living on land is available. A novel cysteine-rich antimicrobial peptide (mytimacin-AF) belonging to the peptide family of mytimacins was purified and characterized from the mucus of the snail of Achatina fulica. Its cDNA was also cloned from the cDNA library. Mytimacin-AF is composed of 80 amino acid residues including 10 cysteines. Mytimacin-AF showed potent antimicrobial activity against Gram-negative and Gram-positive bacteria and the fungus Candida albicans. Among tested microorganisms, it exerted strongest antimicrobial activity against Staphylococcus aureus with a minimal peptide concentration (MIC) of 1.9 μg/ml. Mytimacin-AF had little hemolytic activity against human blood red cells. The current work confirmed the presence of mytimacin-like antimicrobial peptide in land-living mollusks. 10.1016/j.peptides.2012.09.001
    Antimicrobial properties of terrestrial snail and slug mucus. Cilia Giovanni,Fratini Filippo Journal of complementary & integrative medicine 10.1515/jcim-2017-0168
    Studies on the Adhesive Property of Snail Adhesive Mucus. Newar Janu,Ghatak Archana Langmuir : the ACS journal of surfaces and colloids Many gastropod molluscs are known to secrete mucus which allow these animals to adhere to a substrate while foraging over it. While the mucus is known to provide strong adhesion to both dry and wet surfaces, including both horizontal and vertical ones, no systematic study has been carried out to understand the strength of such adhesion under different conditions. We report here results from preliminary studies on adhesion characteristics of the mucus of a snail found in eastern India, Macrochlamys indica. When perturbed, the snail was found to secrete its adhesive mucus, which was collected and subjected to regular adhesion tests. The hydrated mucus was used as such, and also as mixed with buffer of different pH. These experiments suggest that the mucus was slightly alkaline, and showed the maximum adhesion strength of 9 kPa when present in an alkaline buffer. Preliminary studies indicate that adhesive force is related to the ability of the mucus to incorporate water. In alkaline condition, the gel like mass that it forms, incorporate water from a wet surface and enable strong adhesion. 10.1021/acs.langmuir.5b03498
    Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose. López Angulo Daniel Enrique,do Amaral Sobral Paulo José International journal of biological macromolecules Biologically active scaffolds used in tissue engineering and regenerative medicine have been generating promising results in skin replacement. The present study aims to test the hypothesis that the incorporation of Aloe vera and snail mucus into scaffolds based on gelatin and chitosan could improve their structure, composition and biodegradability, with a potential effect on bioactivity. Homogeneous pore diameter as well as pore walls in the composite scaffold could be seen in the SEM image. The pores in the scaffolds were interconnected and their sizes ranged from 93 to 296μm. The addition of Aloe vera and snail mucus enlarged the mean pore size with increased porosity and caused changes in the pore architecture. The FTIR analysis has shown good affinity and interaction between the matrix and the Aloe, which may decrease water-binding sites, so this fact hindered the water absorption capacity of the material. The mechanical properties could explain the highest swelling capacity of the snail scaffold, because the high percentage of elongation could facilitate the entry of liquid in it, generating a matrix with plenty of fluid retention. The real innovation in the present work could be the use of these substances (Aloe and snail mucus) for tissue engineering. 10.1016/j.ijbiomac.2016.07.029
    Functional properties of chitosan films modified by snail mucus extract. Di Filippo Maria Francesca,Panzavolta Silvia,Albertini Beatrice,Bonvicini Francesca,Gentilomi Giovanna Angela,Orlacchio Ramona,Passerini Nadia,Bigi Adriana,Dolci Luisa Stella International journal of biological macromolecules Snail mucus is an attractive natural substance, which is increasingly used in cosmetic creams and syrups thanks to its emollient, moisturizing, protective and reparative properties. The aim of the present study was to explore the physicochemical properties of chitosan-based films added with snail mucus extracted from Helix Aspersa Muller. To this aim, chitosan films at different content of snail mucus were fabricated by simple solvent casting technique. The results of X-ray diffraction analyses, tensile mechanical tests, Infrared spectroscopy and thermogravimetry demonstrated that snail mucus addition strongly modifies the properties of chitosan films. In particular, it acted like a plasticizer enhancing films extensibility up to ten times and strongly improving their water barrier and bioadhesion properties, with a trend depending on Snail mucus content. Furthermore, it provides the films with antibacterial properties and enhanced cytocompatibility, yielding materials with tailored properties for specific requirements. 10.1016/j.ijbiomac.2019.11.230