Cardiac Myxoma: Review and Update of Contemporary Immunohistochemical Markers and Molecular Pathology. Velez Torres Jaylou M,Martinez Duarte Ernesto,Diaz-Perez Julio A,Rosenberg Andrew E Advances in anatomic pathology Cardiac myxoma is an uncommon benign mesenchymal neoplasm of the heart. It usually arises in the left atrium, near the valve of the fossa ovalis, and most frequently affects adults in the third through the sixth decades of life. It is hypothesized to arise from subendothelial vasoformative reserve cells or primitive cells that differentiate along the lines of the endothelium, but this remains speculative. Microscopically, the neoplastic cells are arranged individually, and nests, and are oriented in single or multiple layers around vascular channels. The neoplastic cells are immunoreactive for vimentin, calretinin, S100, nonspecific enolase, factor VIII, CD31, and CD34. The tumor can have diverse clinical presentations depending on its location and extent of disease and is predisposed to embolization. The current treatment is prompt surgical excision. 10.1097/PAP.0000000000000275

Cardiac Myxoma: A Rare Case Series of 3 Patients and a Literature Review. Wang Haiyan,Li Quan,Xue Minghua,Zhao Pengzhan,Cui Jing Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Myxoma is the most common tumor in the heart. A typical myxoma is relatively straightforward to diagnose. However, certain cardiac myxomas have rare features. We report three extremely rare cases of cardiac myxoma. One case involved a myxoma that originated from the annulus of the tricuspid after valvuloplasty, one case involved myxomas associated with left atrial thrombus and severe mitral stenosis, and the third case involved myxoma combined with severe calcification. All three cases were diagnosed by echocardiography and pathology. We also review clinical presentations and diagnostic characteristics of cardiac myxomas. 10.1002/jum.14264