Regulatory mechanisms of Sesn2 and its role in multi-organ diseases. Wang B Jie,Wang Shudong,Xiao Mengjie,Zhang Jingjing,Wang A Jie,Guo Yuanfang,Tang Yufeng,Gu Junlian Pharmacological research Sestrin2 (Sesn2) is a powerful anti-oxidant that can prevent acute and chronic diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and immune system diseases. However, there is a limited number of reviews that have summarized the effects of Sesn2 in heart and vascular diseases, and very less literature-based information is available on involvement of Sesn2 in renal and respiratory pathologies. This review summarizes the latest research on Sesn2 in multi-organ stress responses, with a particular focus on the protective role of Sesn2 in cardiovascular, respiratory, and renal diseases, emphasizing the potential therapeutic benefit of targeting Sesn2 in stress-related diseases. 10.1016/j.phrs.2020.105331