Acute unilateral proptosis in childhood: suspect myeloid sarcoma. Manpreet Singh,Sagarika Snehi,Pulkit Rastogi,Kalaivani Jayakumar,Manpreet Kaur,Pankaj Gupta Romanian journal of ophthalmology As the first and only presenting feature of acute myeloid leukemia (AML), unilateral proptosis in children is uncommon. We report the cases of two girls who had no systemic clinical manifestations of AML. Orbital imaging showed space-occupying infiltrating lesions without surrounding bone erosion. Incisional biopsy and immunohistochemistry were diagnostic for myeloid sarcoma. Systemic workup and bone marrow examination showed features of AML. Systemic chemotherapy was administered to both children, who responded well to the treatment. Myeloid sarcoma should be kept in the differentials of the children presenting with isolated proptosis. Immunohistochemistry may provide an accurate diagnosis and early treatment may lead to a prompt recovery with a good prognosis. 10.22336/rjo.2021.17

Adult orbital myeloid sarcoma (granulocytic sarcoma): two cases and review of the literature. Mangla Deepak,Dewan Mohit,Meyer Dale R Orbit (Amsterdam, Netherlands) BACKGROUND/AIMS:[corrected] To report two rare cases of orbital myeloid sarcoma in adults and discuss special features relevant to this entity. METHODS:Complete ophthalmologic and systemic examinations followed by incisional biopsy and pathological examination. RESULTS:Two cases of myeloid sarcoma with orbital involvement were identified. Both cases presented with a clinical picture and imaging which demonstrated infiltrative orbital masses. When combined with 8 previous reported cases, 8/10 demonstrated systemic AML involvement. CONCLUSIONS:Orbital myeloid sarcoma is a rare entity in adults and highly associated with myelodysplastic syndromes, especially acute myelogenous leukemia (AML). It may present at any stage of AML and requires appropriate workup and treatment, though generally carries a poor prognosis. 10.3109/01676830.2012.723784

Orbital myeloid sarcoma (chloroma): Report of 2 cases and literature review. American journal of ophthalmology case reports PURPOSE:Myeloid sarcoma (MS) of the orbit is an uncommon condition in occurring in children, generally coupled to myeloproliferative neoplasms. OBSERVATIONS:We describe two rare cases of orbital MS in young boys with aggressive local symptoms but without evidence of acute myeloid leukemia (AML), both patients underwent orbitotomy for gross-tumor resection and biopsy. At follow up, there was no evidence of recurrence nor evolution of the myeloproliferative neoplasms clinically and by radiological and laboratory work-up. We also provide a detailed description of the magnetic resonance imaging presentation, with an extensive pathological analysis correlation. CONCLUSIONS AND IMPORTANCE:A comprehensive revision of the literature on isolated orbital MS was carried out with particular emphasis on clues for differential diagnosis and treatment options, stressing the need to consider MS even in the absence of sign and symptoms of an underlying myeloproliferative disorders. 10.1016/j.ajoc.2020.100806