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共1篇 平均IF=4.6 (4.6-4.6)更多分析
  • 3区Q1影响因子: 4.6
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    1. Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population.
    1. NLRP3炎症相关的基因启动子甲基以及在南方中国汉族人群2型糖尿病血管并发症中介作用的关联分析。
    作者：Zhou Zixing , Wang Lijun , Wen Zihao , Zheng Shaoling , Ye Xiaohong , Liu Dandan , Wu Jing , Zou Xiaoqian , Liu Yumei , Wang Yao , Dong Shirui , Huang Xiuxia , Du Xiuben , Zhu Kehui , Chen Xiaojing , Huang Shiqi , Zeng Chengli , Han Yajing , Zhang Baohuan , Nie Lihong , Yang Guang , Jing Chunxia
    期刊：Frontiers in endocrinology
    日期：2018-11-29
    DOI ：10.3389/fendo.2018.00709
    To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM. A case-control study was used to determine the association between population characteristics, the methylation level in the promoter region of the NLRP3, AIM2, and ASC genes and T2DM and vascular complications. A mediating effect among genes-environment-T2DM and the interaction of gene-gene or gene-environment factors was explored. In the logistic regression model with adjusted covariants, healthy people with lower total methylation levels in the AIM2 promoter region exhibited a 2.29-fold [OR: 2.29 (1.28~6.66), = 0.011] increased risk of developing T2DM compared with higher-methylation individuals. T2DM patients without any vascular complications who had lower methylation levels (
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