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    Listeria meningitis and ventriculitis in an immunocompetent child: case report and literature review. Ben Shimol S,Einhorn M,Greenberg D Infection Listeria monocytogenes meningitis is very rare in immunocompetent children. We present a case of a previously healthy 6-year-old girl who developed L. monocytogenes meningitis and ventriculitis. We also review the medical literature on non-neonatal L. monocytogenes meningitis in immunocompetent children. 10.1007/s15010-011-0177-6
    Pearls & Oy-sters: Diagnosis and Subtyping of Listeria Ventriculitis in an Immunocompetent Host. Neurology is a gram-positive food-borne pathogen that causes gastrointestinal symptoms and central nervous system (CNS) infection in susceptible hosts.. Two lineages of cause the majority of neurolisteriosis in humans. In this report, we discuss a case of a 23-year-old previously healthy female who presented with acute-onset rapidly progressive altered mental status after eating undercooked meats at a local restaurant. Given her age and lack of comorbidities, bacterial meningitis was suspected, and she was treated with ceftriaxone, vancomycin, and steroids. Magnetic resonance imaging of the brain was consistent with meningitis and ventriculitis; Cerebrospinal fluid (CSF) analysis also suggested bacterial meningitis. Despite mechanical ventilation, pressors, and ventricular drain placement, she quickly decompensated and died 12 hours after arrival. CSF culture later returned positive for We used whole genome sequencing and near-source comparison to identify the subtype that led to her unexpected presentation. The results suggest that her CSF isolate was consistent with a lineage II serotype, which is known to exhibit greater genetic variation than the more commonly isolated lineage I serotypes. We conclude the discussion with diagnostic and treatment approaches to neurolisteriosis. In susceptible hosts, namely immunocompromised, pregnant, neonatal or elderly patients, infection may result in CNS invasion, causing meningoencephalitis and, rarely, ventriculitis and rhombencephalitis. Although neurolisteriosis most commonly affects individuals with known risk factors, CNS infection is nevertheless possible in otherwise healthy young patients. Suspicion should be raised in patients with an exposure history and do not improve with empiric antibiotics. 10.1212/WNL.0000000000200732
    Complications of Listeria meningitis in two immunocompetent children. Shimbo Asami,Takasawa Kei,Nishioka Masato,Morio Tomohiro,Shimohira Masayuki Pediatrics international : official journal of the Japan Pediatric Society 10.1111/ped.13550
    Listeria monocytogenes meningoencephalitis in adults: analysis of factors related to unfavourable outcome. Pelegrín I,Moragas M,Suárez C,Ribera A,Verdaguer R,Martínez-Yelamos S,Rubio-Borrego F,Ariza J,Viladrich P F,Cabellos C Infection PURPOSE:To analyse the short-term outcome in patients with Listeria monocytogenes meningoencephalitis (LMME) to improve management and outcome. METHODS:Observational study with adult patients with LMME between 1977 and 2009 at a tertiary hospital in Barcelona, Spain. Parameters that predicted outcome were assessed with univariate and logistic regression analysis. RESULTS:Of 59 cases of LMME, 28 occurred in the last decade. Since 1987, a new protocol has been used and 29/45 patients (64%) treated since then received adjuvant dexamethasone. In patients who received this treatment there was a trend towards fewer neurological sequelae (5 vs 33%; p = 0.052). Antiseizure prophylaxis with phenytoin was administered in 13/45 (28%) patients. Seizures occurred in 7/45 (16%) patients, all in the group who did not receive phenytoin. Hydrocephalus presented in 8/59 (14%). It was never present at admission and five patients needed neurosurgical procedures. Sequelae after 3 months were present in 8/45 (18%), mostly cranial nerve palsy. Rhombencephalitis (RE) was related to the presence of neurologic sequelae (OR: 20.4, 95% CI: 1.76-236). Overall mortality was 14/59 (24%), 9/59 (15%) due to neurological causes related to hydrocephalus or seizures. Mortality was defined as early in 36% and late in 64%. In the multivariate analysis, independent risk factors for mortality were presence of hydrocephalus (OR: 17.8, 95% CI: 2.753-114) and inappropriate empirical antibiotic therapy (OR: 6.5, 95% CI: 1.201-35). CONCLUSIONS:Outcome of LMME may be improved by appropriate empirical antibiotic therapy, suspicion and careful management of hydrocephalus. Use of adjuvant dexamethasone or phenytoin in a subgroup of these patients might have a benefit. 10.1007/s15010-014-0636-y
    A case of Listeria meningoencephalitis complicated by hydrocephalus in an immunocompetent infant. Platnaris Antonios,Hatzimichael Athanasios,Ktenidou-Kartali Sofia,Kontoyiannides Kosmas,Kollios Konstantinos,Anagnostopoulos John,Roilides Emmanuel European journal of pediatrics We report a very unusual case of meningoencephalitis due to Listeria monocytogenes in a 7-month-old immunocompetent boy. Cerebrospinal fluid (CSF) culture was initially negative, but was positive on the seventh day. The disease was complicated by seizures and hydrocephalus managed with temporary ventriculostomy. The infant was discharged without obvious neurological sequelae after 30 days and developed without neurological or developmental sequelae at two years of age. Listeria is difficult to isolate and is not susceptible to third-generation cephalosporins commonly used for the empirical treatment of bacterial meningitis. 10.1007/s00431-008-0739-5