Clinical Criteria Correlated with the Incidence of Patients with Non-alcoholic Fatty Liver Disease.
Chien-Min Kung,Cheng-Chuan Liu
Annals of clinical and laboratory science
GOALS:In this study, predictive panels were constructed and validated to recognize an individual with and without nonalcoholic fatty liver disease (NAFLD) based on clinical and biochemical criteria. METHODS:Two hundred and thirty six non-alcoholic adults with no chronic viral hepatitis history were recruited from a medical center in Taiwan in 2013. All subjects were examined for body mass index (BMI), abdominal ultrasonography, blood liver function tests (including alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma glutamyl transpeptidase [GGT]), blood lipids (total cholesterol [TC] and triglyceride [TG]) and blood glucose (BG) tests. RESULTS:NAFLD was observed in 66.97% of subjects. BMI (<0.001), ALT (<0.001), AST (=0.014), GGT (=0.034), TC (=0.026), TG (<0.001) and BG (<0.001) were significantly higher for subjects with NAFLD than subjects without NAFLD. The BMI results (<0.001), TG (<0.001), ALT (<0.001), BG (<0.001), AST (=0.001), and GGT (=0.001) correlated well with the extent of NAFLD. The increasing risks of NAFLD are hypertriglyceridemia (<0.001), high ALT (<0.001), high GGT (=0.009), and hypercholesterolemia (=0.017). Moreover, NAFLD was observed in 98.5% (<0.001) of subjects with three clinical manifestations of body overweight, hypertriglyceridemia and high ALT. Additionally, NAFLD was observed in 96.5% (<0.001) of subjects with other tri-criteria (body overweight, hypertriglyceridemia, and hypercholesterolemia), or 92.6% (<0.001) of subjects with another tri-criteria (body overweight, hypertriglyceridemia, and high GGT). CONCLUSION:The tri-criteria of diagnoses can accurately predict the surveillance of NAFLD.
Sex-Specific Predictors of Metabolic Syndrome Independent of Its Components.
Onat Altan,Can Günay,Çakr Hakan,Özpamuk-Karadeniz Fatma,Karadeniz Yusuf,Yüksel Hüsniye,Şimşek Barş,Ademoğlu Evin
Journal of investigative medicine : the official publication of the American Federation for Clinical Research
To what extent is the metabolic syndrome (MetS) determined beyond its recognized components? In 1702, middle-aged men and women without MetS at baseline, MetS development was identified in 546 participants at a mean of 10.1-year follow-up. Participants subsequently developing MetS had, beyond higher values of MetS traits, significantly higher total and low-density lipoprotein cholesterol, apolipoprotein B, C-reactive protein (CRP), γ-glutamyl transferase (GGT), and lower high-density lipoprotein cholesterol. Females were significantly more frequent never smokers and males had lower values of total testosterone. In logistic regression analyses, adjusted for sex, age, and smoking status, MetS was predicted disparately in the sexes, whereas males exhibited, beyond abdominal obesity, CRP, GGT, and sex hormone-binding globulin (SHBG) as independent predictors, abdominal obesity was not an independent predictor in females in whom other than age, CRP conferred MetS risk, whereas SHBG was and current smoking tended to be protective. A surrogate of hepatic steatosis proved a major mediator of abdominal obesity in determining incident MetS (relative risk, 5.6 [95% confidence interval, 3.4-9.3]) in each sex. We confirm that GGT and SHBG are novel independent MetS determinants. Hepatic steatosis is the major predictor of MetS mediating adiposity in each sex. Abdominal obesity is not an independent determinant in Turkish women in whom autoimmune activation seems to prevail before MetS development.