共0篇 平均IF=NaN (-)更多分析

    加载中

    logo
    Retinal nerve fibre layer thickness in a normal black South African population. Ismail Sarah,Ally Naseer,Alli Hassan Dawood Eye (London, England) BACKGROUND:The measurement of retinal nerve fibre layer (RNFL) thickness on spectral domain OCT (SD-OCT) are compared with built-in age- and gender-matched European normative databases and this difference is used to assist with glaucoma diagnosis. However, there are differences in RNFL thickness between population groups. Therefore, using the built in European normative database as a comparison across all population groups could lead to erroneous results, due to the basic assumption that the normative values for non-European populations are the same as their European counterparts. METHODS:Cross-sectional study of RNFL thickness in normal black South African patients. RESULTS:One hundred and thirty-two eyes of 132 patients were enroled in this study. The mean (SD) age of patients in this study was 41.3 (12.5) years. Males comprised 40.9% (n = 54; p = 0.0367). All RNFL sectors except the temporal sector were significantly thicker than the reference database. The RNFL sectors measured as follows: global (108.7 µm, p < 0.001), superotemporal (152.4 µm, p < 0.001), superonasal (132.6 µm, p < 0.001), inferotemporal (150.1 µm, p < 0.001), inferonasal (129.2 µm, p < 0.001), nasal (77.7 µm, p < 0.001), temporal 74.8 µm, p = 0.9534). CONCLUSION:The RNFL thickness of normal black South Africans is significantly thicker than that of the European database on the Spectralis SD-OCT. This needs to be taken into account when performing RNFL thickness measurements on black patients. 10.1038/s41433-019-0677-7
    Interocular symmetry of retinal nerve fiber layer and optic nerve head parameters measured by Cirrus high-definition optical coherence tomography in a normal pediatric population. Pawar Neelam,Maheshwari Devendra,Ravindran Meenakshi,Ramakrishnan Renagappa Indian journal of ophthalmology PURPOSE:To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT). METHODS:Seventy normal Indian children aged 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT. Differences between the right and left eyes were calculated and values were compared by means of a paired t-test. Subjects were also divided into two groups based on age (under or over 10 years of age). Interocular differences in RNFL and ONH parameters together with sex and age variations for these differences were determined. RESULTS:The mean age of studied pediatric population was 11.83 ± 3.3 years (range 5-17). Average RNFL thickness was 94.46 ± 8.7 μm (± SD) (range 77-111). Differences in the average RNFL between right and left eyes were not statistically significant (P = 0.060). Superior quadrant RNFL was thicker in the left eye and temporal quadrant was thicker in the right eye. Among ONH parameters, there were no statistically significant differences in any parameters, except vertical cup-disc (CD) ratio which was significant (P = 0.007). The 2.5%-97.5% limits of asymmetry were 9 μm for average RNFL, 0.14 for average CD ratio, and 0.22 for vertical CD ratio. Mean interocular RNFL thickness differences in superior, superior nasal, and temporal superior quadrants were 10.61 (P < 0.001), 12.57 (P < 0.001), and 4.46 (P = 0.002) μm, respectively. Interocular nerve fiber layer thickness differences were not significantly correlated with sex, while only significant differences with age were observed in 12 clock hour sector analysis, mainly in nasal inferior and inferior quadrant. CONCLUSIONS:We report the degree of interocular symmetry of RNFL and ONH parameters measured by Cirrus HD-OCT in a healthy pediatric population. The normal interocular RNFL asymmetry should not exceed 9 μm and vertical CD ratio beyond 0.22 should be considered for further investigations. The physiologic asymmetry provided by this study may assist in identifying changes in RNFL thickness and ONH parameters in pediatric glaucoma and ONH disorders. 10.4103/ijo.IJO_71_17
    A cross-sectional study to determine the normal corneal epithelial thickness in Indian population using 9-mm wide optical coherence tomography scans. Indian journal of ophthalmology PURPOSE:To study the corneal epithelial thickness with 9-mm scans of optical coherence tomography in normal Indians with appropriate representation of all age groups. METHODS:This was a cross-sectional observational study. 263 patients were divided into the age groups 5-20 years, 21-35 years, 36-50 years and more than 51 years were recruited for the study. All patients underwent a detailed ophthalmic examination. Patients found to have any ocular surface or intraocular disease condition (except cataract and refractive error), or who had undergone any ophthalmic surgery in the past, or had corneal topography changes suggestive of corneal ectasias (screened in patients with astigmatism more than 3 diopters) or had been continuously using any topical medication in either eye for a period of 3 months or more with the last instillation being within 1 month of inclusion in the study were excluded. All subjects underwent corneal epithelial thickness measurement with anterior segment optical coherence tomography (AS-OCT) on the Avanti OCT (Model RTVueXR1002, Optovue, USA). The corneal epithelial thickness (CET) data from 25 sectors in each eye were analyzed. RESULTS:263 right and left eyes of 263 patients were analyzed in the study. Mean CETs in the central 2 mm zone were 54.13 ± 4.51 μm and 54.37 ± 3.75 μm for the right and left eyes, respectively. The superior peripheral sectors and inferior paracentral sectors were the thinnest and the thickest sectors, respectively, in both eyes. CONCLUSION:CET parameters for Indian eyes are comparable to those reported from racially distinct and geographically distant study subjects. 10.4103/ijo.IJO_244_21
    Macular and choroidal thicknesses in a healthy Hispanic population evaluated by high-definition spectral-domain optical coherence tomography (SD-OCT). Cortés Diana A,Roca Daniela,Navarro Pedro Iván,Rodríguez Francisco J International journal of retina and vitreous PURPOSE:To report normal values of macular and choroidal thickness obtained from a healthy Hispanic population using Optovue (Optovue Inc, Freemont CA, USA) spectral domain optical coherence tomography (SD-OCT). DESIGN:Observational, cross-sectional, correlation study. METHODS:A total of 290 eyes (145 healthy subjects) were included; 69% of subjects were female. The median age was 39 ± 29 years (IQR), with a range between 18 and 89 years. The study sample was stratified into three age groups: Group 1, 18-40 years (50.3%), Group 2, 41-60 years (30.7%), and Group 3, older than 61 years (19%). Central macular, perifoveal (inner quadrants), and parafoveal (outer quadrants) thicknesses were estimated. In addition, central and peripheral choroidal thicknesses were estimated. Data analysis was performed to calculate the standardized mean difference according to the variance (Student's t-test) and its differences with Epidat 4.1. RESULTS:Median macular central thickness was 250 ±30 µm (IQR) with Optovue. Median central choroidal thickness was 263 ± 48 µm (IQR). Median central choroidal thickness was greater than mean peripheral thickness. Macular evaluation showed a statistically significant difference in central, perifoveal, and parafoveal thicknesses, with lower values being recorded for the study sample compared with the manufacturer's data. CONCLUSIONS:SD-OCT has become a useful tool to obtain high-resolution images of the macula and choroid. This method allows precise assessment of the retinal and choroidal layers to diagnose and follow up posterior segment diseases. We are reporting normal cut-off values of macular and choroidal thicknesses in healthy Hispanic subjects evaluated with Optovue SD-OCT as new diagnostic normal parameters for research and clinical activities. 10.1186/s40942-020-00270-9