
A mindfulness-based intervention to increase resilience to stress in university students (the Mindful Student Study): a pragmatic randomised controlled trial.
Galante Julieta,Dufour Géraldine,Vainre Maris,Wagner Adam P,Stochl Jan,Benton Alice,Lathia Neal,Howarth Emma,Jones Peter B
The Lancet. Public health
BACKGROUND:The rising number of young people going to university has led to concerns about an increasing demand for student mental health services. We aimed to assess whether provision of mindfulness courses to university students would improve their resilience to stress. METHODS:We did this pragmatic randomised controlled trial at the University of Cambridge, UK. Students aged 18 years or older with no severe mental illness or crisis (self-assessed) were randomly assigned (1:1), via remote survey software using computer-generated random numbers, to receive either an 8 week mindfulness course adapted for university students (Mindfulness Skills for Students [MSS]) plus mental health support as usual, or mental health support as usual alone. Participants and the study management team were aware of group allocation, but allocation was concealed from the researchers, outcome assessors, and study statistician. The primary outcome was self-reported psychological distress during the examination period, as measured with the Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM), with higher scores indicating more distress. The primary analysis was by intention to treat. This trial is registered with the Australia and New Zealand Clinical Trials Registry, number ACTRN12615001160527. FINDINGS:Between Sept 28, 2015, and Jan 15, 2016, we randomly assigned 616 students to the MSS group (n=309) or the support as usual group (n=307). 453 (74%) participants completed the CORE-OM during the examination period and 182 (59%) MSS participants completed at least half of the course. MSS reduced distress scores during the examination period compared with support as usual, with mean CORE-OM scores of 0·87 (SD 0·50) in 237 MSS participants versus 1·11 (0·57) in 216 support as usual participants (adjusted mean difference -0·14, 95% CI -0·22 to -0·06; p=0·001), showing a moderate effect size (β -0·44, 95% CI -0·60 to -0·29; p<0·0001). 123 (57%) of 214 participants in the support as usual group had distress scores above an accepted clinical threshold compared with 88 (37%) of 235 participants in the MSS group. On average, six students (95% CI four to ten) needed to be offered the MSS course to prevent one from experiencing clinical levels of distress. No participants had adverse reactions related to self-harm, suicidality, or harm to others. INTERPRETATION:Our findings show that provision of mindfulness training could be an effective component of a wider student mental health strategy. Further comparative effectiveness research with inclusion of controls for non-specific effects is needed to define a range of additional, effective interventions to increase resilience to stress in university students. FUNDING:University of Cambridge and National Institute for Health Research Collaboration for Leadership in Applied Health Research and Care East of England.
10.1016/S2468-2667(17)30231-1
Mindfulness Interventions.
Creswell J David
Annual review of psychology
Mindfulness interventions aim to foster greater attention to and awareness of present moment experience. There has been a dramatic increase in randomized controlled trials (RCTs) of mindfulness interventions over the past two decades. This article evaluates the growing evidence of mindfulness intervention RCTs by reviewing and discussing (a) the effects of mindfulness interventions on health, cognitive, affective, and interpersonal outcomes; (b) evidence-based applications of mindfulness interventions to new settings and populations (e.g., the workplace, military, schools); (c) psychological and neurobiological mechanisms of mindfulness interventions; (d) mindfulness intervention dosing considerations; and (e) potential risks of mindfulness interventions. Methodologically rigorous RCTs have demonstrated that mindfulness interventions improve outcomes in multiple domains (e.g., chronic pain, depression relapse, addiction). Discussion focuses on opportunities and challenges for mindfulness intervention research and on community applications.
10.1146/annurev-psych-042716-051139
Brief mindfulness training for negative affectivity: A systematic review and meta-analysis.
Journal of consulting and clinical psychology
OBJECTIVE:Over the last 10 years, there has been a dramatic increase in published randomized controlled trials (RCTs) of brief mindfulness training (from single-session inductions to multisession interventions lasting up to 2 weeks), with some preliminary indications that these training programs may improve mental health outcomes, such as negative affectivity. This meta-analysis aimed to evaluate whether brief mindfulness training reliably reduces negative affectivity. METHOD:PubMed, PsycINFO, and the Mindfulness Research Monthly Newsletter were systematically searched for brief mindfulness intervention RCTs assessing negative affectivity outcomes (e.g., depression, rumination, anxiety, stress). Sixty-five RCTs, including 5,489 participants predominantly without experience in meditation (64.64% female, mean age = 24.62), qualified for the meta-analytic review. RESULTS:The meta-analysis revealed a small but significant effect of brief mindfulness training on reducing negative affectivity compared to control programs (g = .21, p < .001). The overall effect size was significantly moderated by participant characteristics: community samples (g = .41, p < .001) produced larger training effects compared to student samples (g = .14, p = .001; Qbetween p = .03). No significant effect size differences were found between clinical and nonclinical samples. However, when accounting for publication bias, the overall effect size of brief mindfulness training programs on negative affectivity was significantly reduced (g = .04). CONCLUSIONS:Brief mindfulness training programs are increasingly popular approaches for reducing negative affectivity. This meta-analysis indicates that brief mindfulness training modestly reduces negative affectivity. Quantitative analyses indicated the presence of publication bias (i.e., unpublished null effect studies), highlighting the need to continue rigorous evaluation of brief mindfulness interventions. (PsycINFO Database Record
10.1037/ccp0000324
The effect of meditative movement on sleep quality: A systematic review.
Wang Fang,Eun-Kyoung Lee Othelia,Feng Fan,Vitiello Michael V,Wang Weidong,Benson Herbert,Fricchione Gregory L,Denninger John W
Sleep medicine reviews
The purpose of this systematic review was to identify and assess evidence related to the efficacy of meditative movement (MM) on sleep quality. We conducted a comprehensive review of relevant studies drawn from English and Chinese databases. Only randomized controlled trials (RCTs) reporting outcomes of the effects of MM (tai chi, qi gong, and yoga) on sleep quality were taken into consideration. Twenty-seven RCTs fulfilled our inclusion criteria and formed the basis for this review. Due to clinical heterogeneity, no meta-analysis was performed. Seventeen studies received a Jadad score of ≥3 and were considered high-quality studies. Findings of the 17 studies showed that MM has beneficial effects for various populations on a range of sleep measures. Improvement in sleep quality was reported in the majority of studies and was often accompanied by improvements in quality of life, physical performance, and depression. However, studies to date generally have significant methodological limitations. Additional RCTs with rigorous research designs focusing on sleep quality or insomnia and testing specific hypotheses are needed to clearly establish the efficacy of MM in improving sleep quality and its potential use as an intervention for various populations.
10.1016/j.smrv.2015.12.001
Mindfulness-based interventions for psychiatric disorders: A systematic review and meta-analysis.
Goldberg Simon B,Tucker Raymond P,Greene Preston A,Davidson Richard J,Wampold Bruce E,Kearney David J,Simpson Tracy L
Clinical psychology review
Despite widespread scientific and popular interest in mindfulness-based interventions, questions regarding the empirical status of these treatments remain. We sought to examine the efficacy of mindfulness-based interventions for clinical populations on disorder-specific symptoms. To address the question of relative efficacy, we coded the strength of the comparison group into five categories: no treatment, minimal treatment, non-specific active control, specific active control, and evidence-based treatment. A total of 142 non-overlapping samples and 12,005 participants were included. At post-treatment, mindfulness-based interventions were superior to no treatment (d=0.55), minimal treatment (d=0.37), non-specific active controls (d=0.35), and specific active controls (d=0.23). Mindfulness conditions did not differ from evidence-based treatments (d=-0.004). At follow-up, mindfulness-based interventions were superior to no treatment conditions (d=0.50), non-specific active controls (d=0.52), and specific active controls (d=0.29). Mindfulness conditions did not differ from minimal treatment conditions (d=0.38) and evidence-based treatments (d=0.09). Effects on specific disorder subgroups showed the most consistent evidence in support of mindfulness for depression, pain conditions, smoking, and addictive disorders. Results support the notion that mindfulness-based interventions hold promise as evidence-based treatments.
10.1016/j.cpr.2017.10.011
Decreased electrophysiological activity represents the conscious state of emptiness in meditation.
Hinterberger Thilo,Schmidt Stephanie,Kamei Tsutomu,Walach Harald
Frontiers in psychology
Many neuroscientific theories explain consciousness with higher order information processing corresponding to an activation of specific brain areas and processes. In contrast, most forms of meditation ask for a down-regulation of certain mental processing activities while remaining fully conscious. To identify the physiological properties of conscious states with decreased mental and cognitive processing, the electrical brain activity (64 channels of EEG) of 50 participants of various meditation proficiencies was measured during distinct and idiosyncratic meditative tasks. The tasks comprised a wakeful "thoughtless emptiness (TE)," a "focused attention," and an "open monitoring" task asking for mindful presence in the moment and in the environment without attachment to distracting thoughts. Our analysis mainly focused on 30 highly experienced meditators with at least 5 years and 1000 h of meditation experience. Spectral EEG power comparisons of the TE state with the resting state or other forms of meditation showed decreased activities in specific frequency bands. In contrast to a focused attention task the TE task showed significant central and parietal gamma decreases (p < 0.05). Compared to open monitoring TE expressed decreased alpha and beta amplitudes, mainly in parietal areas (p < 0.01). TE presented significantly less delta (p < 0.001) and theta (p < 0.05) waves than a wakeful closed eyes resting condition. A group of participants with none or little meditation practice did not present those differences significantly. Our findings indicate that a conscious state of TE reached by experienced meditators is characterized by reduced high-frequency brain processing with simultaneous reduction of the low frequencies. This suggests that such a state of meditative conscious awareness might be different from higher cognitive and mentally focused states but also from states of sleep and drowsiness.
10.3389/fpsyg.2014.00099
Meditation Awareness Training for the Treatment of Sex Addiction: A Case Study.
Van Gordon William,Shonin Edo,Griffiths Mark D
Journal of behavioral addictions
Background Sex addiction is a disorder that can have serious adverse functional consequences. Treatment effectiveness research for sex addiction is currently underdeveloped, and interventions are generally based on the guidelines for treating other behavioral (as well as chemical) addictions. Consequently, there is a need to clinically evaluate tailored treatments that target the specific symptoms of sex addiction. It has been proposed that second-generation mindfulness-based interventions (SG-MBIs) may be an appropriate treatment for sex addiction because in addition to helping individuals increase perceptual distance from craving for desired objects and experiences, some SG-MBIs specifically contain meditations intended to undermine attachment to sex and/or the human body. The current study conducts the first clinical investigation into the utility of mindfulness for treating sex addiction. Case presentation An in-depth clinical case study was conducted involving an adult male suffering from sex addiction that underwent treatment utilizing an SG-MBI known as Meditation Awareness Training (MAT). Following completion of MAT, the participant demonstrated clinically significant improvements in addictive sexual behavior, as well as reductions in depression and psychological distress. The MAT intervention also led to improvements in sleep quality, job satisfaction, and non-attachment to self and experiences. Salutary outcomes were maintained at 6-month follow-up. Discussion and conclusion The current study extends the literature exploring the applications of mindfulness for treating behavioral addiction, and findings indicate that further clinical investigation into the role of mindfulness for treating sex addiction is warranted.
10.1556/2006.5.2016.034
Meditation Effects on Anxiety and Resilience of Preadolescents and Adolescents: A Randomized Controlled Study.
Gomes Alexandra,Vieira Dos Santos Joana,Vieira Luís Sérgio
Children (Basel, Switzerland)
Meditation has been described as having a positive impact on well-being while reducing anxiety and stress among those who practice, mainly working as a resource to cope with everyday difficulties. As a simple and easy to apply meditation technique, transcendental meditation (TM) has shown promising results in adults and in children, although more studies are needed to show the impact on psychological and behavioral dimensions in children and adolescents. This quasi-experimental, pre-test-post-test study, with a control group, aimed to evaluate the impact of TM on the stress and resilience of children and adolescents, with ages between 9 and 16 years old. Participants were selected within schools which implemented the Quiet Time Program (QT), from those who volunteered to participate. They were randomly assigned to an experimental group (immediate TM learning) and to a control group (delayed TM learning). A repeated measures ANOVA showed an interaction of time and group on externalizing behavior, from the strengths and difficulties measure. The experimental group decreased on externalizing less adjusted behaviors, while the control group increased in this aspect, after a twelve-week period. TM failed to reduce anxiety and to contribute to resilience in the TM experimental group. Both groups improved anxiety indicators. The results might suggest students were acting upon their expectation of improvement on practicing TM or solely modifying their behavior along the contextual factors, which affected both groups equally.
10.3390/children8080689
The effects of long meditation on plasma melatonin and blood serotonin.
Solberg Erik E,Holen Are,Ekeberg Øivind,Østerud Bjarne,Halvorsen Ragnhild,Sandvik Leiv
Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND:The benefits of meditation are well documented, but the biochemical mechanisms have not been fully identified. One effect mechanism may be via influence on neurotransmitters. MATERIAL/METHODS:Therefore, plasma melatonin and blood serotonin concentrations were measured before and after one hour of meditation in advanced male meditators (n=27, mean age 46 years). They were compared with a matched reference group (n=29, mean age 43 years) who rested for one hour. In the meditators, melatonin and serotonin from before and after three consecutive hours of meditation were also compared. RESULTS:Initially, the median melatonin level was 4.9 pg/ml-1 in the meditators and 3.1 pg/ml-1 in the reference group (p<0.01). After one hour of practice, melatonin had decreased to a median of 3.4 pg/ml-1 in the meditators (p<0.0001), but was unchanged in the reference group. After three hours of meditation, melatonin had declined further in the meditators. After one hour of practice, serotonin concentrations decreased in both the meditators and the reference group (p<0.01). CONCLUSIONS:The findings suggest that advanced meditators have higher melatonin levels than non-meditators. Melatonin decreases during long meditation, a finding the study does not explain. Serotonin declines after both one-hour meditation and rest, indicating that serotonin may be a marker of general rest and not meditation-specific relaxation.
Integrative review of research related to meditation, spirituality, and the elderly.
Lindberg Deborah A
Geriatric nursing (New York, N.Y.)
Recently, increased attention has been given to meditation-relaxation strategies to improve physical health, reduce pain, enhance immune response, improve emotional well-being, and foster spiritual growth. This article reviews research conducted in the last 25 years about meditation and spirituality, in particular as it relates to the health of the elderly. This review supports the hypothesis that meditation can be taught to the elderly, even those with dementia. The results also support the hypothesis that meditation and spiritual practices could promote significant social and emotional benefits for those in social isolation. Specific treatment plan interventions for nursing homes are discussed. Future research should investigate the effectiveness of various types of meditative and spiritual practices to nursing home residents.
10.1016/j.gerinurse.2005.09.013
Assessment of Cardiovascular Parameters during Meditation with Mental Targeting in Varsity Swimmers.
Rich Tyvin A,Pfister Robert,Alton John,Gerdt David,Baruch Martin
Evidence-based complementary and alternative medicine : eCAM
Introduction. Athletes who develop an immunosuppressed state because of intensive training get upper respiratory infections (URIs) and may respond to meditation. Reflective exercise (RE), a westernized form of Qigong, combines meditation, breathing, and targeted mental attention to an internal pulsatile sensation, previously shown to protect varsity swimmers from URIs during the height of training. We report here the evaluation of cardiovascular parameters measured during meditation combined with targeted imagery (interoception) in a cohort of varsity swimmers taught RE. Methods. Thirteen subjects were enrolled on a prospective protocol that used the CareTaker, a noninvasive cardiovascular monitor before, during, and after RE training. Questionnaires regarding targeted mental imagery focusing on a pulsatile sensation were collected. The cardiovascular parameters include heart rate, blood pressure, and heart rate variability (HRV). Results. Increased variance in the subjects' BP and HRV was observed over the training period of 8 weeks. In nine subjects there was an increased low frequency (LF) HRV that was significantly (p < 0.05) associated with the subject's awareness of the pulsatile sensation that makes up a basic part of the RE practice. Summary. These data support further evaluation of HRV measurements in subjects while meditating with mental imagery. This direction could contribute to better understanding of neurocardiac mechanisms that relate meditation to enhanced immunity.
10.1155/2016/7923234
Long-term concentrative meditation and cognitive performance among older adults.
Prakash Ravi,Rastogi Priyanka,Dubey Indu,Abhishek Priyadarshee,Chaudhury Suprakash,Small Brent J
Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
BACKGROUND:The general consensus that cognitive abilities decline with advancing age is supported by several studies that have reported that older adults perform more poorly on multiple tests of cognitive performance as compared to younger adults. To date, preventive measures against this cognitive decline have been mainly focused on dietary, physical, and lifestyle behaviors which could allow older adults to maintain their cognitive abilities into late life. However, much less stress has been laid on evaluating meditation as a preventive measure in such cases in spite of the fact that the role of meditation on attention has been proved in several studies. In the current study, we extend this preliminary idea, examining the practice of concentrative meditation and the differences in the cognitive performance of older adults who have or have not employed this practice long term. METHODOLOGY:This was a cross-sectional study comparing the cognitive performance of meditators and non-meditators in the geriatric age group. Twenty (age > 55 years) long-term practitioners of Vihangam Yoga meditation (>10 years of practice) were recruited in the present study and were applied six paper-pencil neuropsychological tests for assessment of short-term memory, perceptual speed, attention, and executive functioning. The tests used were: (1) the Digit Span test, (2) the Stroop Color Word test, (3) the Trailmaking test, (4) the Letter Cancellation Task, (5) the digit symbol substitution test, and (6) the Rule Shift Card Test. All the tests were also applied to 20 age- and education-matched geriatric adults who have not practiced the meditation technique. RESULTS:Vihangam Yogis showed significantly better performances in all these tests of attention (p < .05) except for the digit backward test, where a trend (p = .08) was found in favor of meditators. CONCLUSION:Long-term Vihangam Yoga meditators have superior cognitive abilities than non-meditators in the old age group. This technique should be studied further for its ability to prevent age-related cognitive decline.
10.1080/13825585.2011.630932
Meditation programs for psychological stress and well-being: a systematic review and meta-analysis.
Goyal Madhav,Singh Sonal,Sibinga Erica M S,Gould Neda F,Rowland-Seymour Anastasia,Sharma Ritu,Berger Zackary,Sleicher Dana,Maron David D,Shihab Hasan M,Ranasinghe Padmini D,Linn Shauna,Saha Shonali,Bass Eric B,Haythornthwaite Jennifer A
JAMA internal medicine
IMPORTANCE:Many people meditate to reduce psychological stress and stress-related health problems. To counsel people appropriately, clinicians need to know what the evidence says about the health benefits of meditation. OBJECTIVE:To determine the efficacy of meditation programs in improving stress-related outcomes (anxiety, depression, stress/distress, positive mood, mental health-related quality of life, attention, substance use, eating habits, sleep, pain, and weight) in diverse adult clinical populations. EVIDENCE REVIEW:We identified randomized clinical trials with active controls for placebo effects through November 2012 from MEDLINE, PsycINFO, EMBASE, PsycArticles, Scopus, CINAHL, AMED, the Cochrane Library, and hand searches. Two independent reviewers screened citations and extracted data. We graded the strength of evidence using 4 domains (risk of bias, precision, directness, and consistency) and determined the magnitude and direction of effect by calculating the relative difference between groups in change from baseline. When possible, we conducted meta-analyses using standardized mean differences to obtain aggregate estimates of effect size with 95% confidence intervals. FINDINGS:After reviewing 18 753 citations, we included 47 trials with 3515 participants. Mindfulness meditation programs had moderate evidence of improved anxiety (effect size, 0.38 [95% CI, 0.12-0.64] at 8 weeks and 0.22 [0.02-0.43] at 3-6 months), depression (0.30 [0.00-0.59] at 8 weeks and 0.23 [0.05-0.42] at 3-6 months), and pain (0.33 [0.03- 0.62]) and low evidence of improved stress/distress and mental health-related quality of life. We found low evidence of no effect or insufficient evidence of any effect of meditation programs on positive mood, attention, substance use, eating habits, sleep, and weight. We found no evidence that meditation programs were better than any active treatment (ie, drugs, exercise, and other behavioral therapies). CONCLUSIONS AND RELEVANCE:Clinicians should be aware that meditation programs can result in small to moderate reductions of multiple negative dimensions of psychological stress. Thus, clinicians should be prepared to talk with their patients about the role that a meditation program could have in addressing psychological stress. Stronger study designs are needed to determine the effects of meditation programs in improving the positive dimensions of mental health and stress-related behavior.
10.1001/jamainternmed.2013.13018
Short-term autonomic and cardiovascular effects of mindfulness body scan meditation.
Ditto Blaine,Eclache Marie,Goldman Natalie
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
BACKGROUND:Recent research suggests that the Mindfulness-Based Stress Reduction program has positive effects on health, but little is known about the immediate physiological effects of different components of the program. PURPOSE:To examine the short-term autonomic and cardiovascular effects of one of the techniques employed in mindfulness meditation training, a basic body scan meditation. METHODS:In Study 1, 32 healthy young adults (23 women, 9 men) were assigned randomly to either a meditation, progressive muscular relaxation or wait-list control group. Each participated in two laboratory sessions 4 weeks apart in which they practiced their assigned technique. In Study 2, using a within-subjects design, 30 healthy young adults (15 women, 15 men) participated in two laboratory sessions in which they practiced meditation or listened to an audiotape of a popular novel in counterbalanced order. Heart rate, cardiac respiratory sinus arrhythmia (RSA), and blood pressure were measured in both studies. Additional measures derived from impedance cardiography were obtained in Study 2. RESULTS:In both studies, participants displayed significantly greater increases in RSA while meditating than while engaging in other relaxing activities. A significant decrease in cardiac pre-ejection period was observed while participants meditated in Study 2. This suggests that simultaneous increases in cardiac parasympathetic and sympathetic activity may explain the lack of an effect on heart rate. Female participants in Study 2 exhibited a significantly larger decrease in diastolic blood pressure during meditation than the novel, whereas men had greater increases in cardiac output during meditation compared to the novel. CONCLUSIONS:The results indicate both similarities and differences in the physiological responses to body scan meditation and other relaxing activities.
10.1207/s15324796abm3203_9
Changes in Heart Rate Variability During Heartfulness Meditation: A Power Spectral Analysis Including the Residual Spectrum.
Léonard Anne,Clément Serge,Kuo Cheng-Deng,Manto Mario
Frontiers in cardiovascular medicine
Meditation refers to a group of practices commonly proposed to treat stress-related conditions and improve overall wellness. In particular, meditation might exert beneficial actions on heart rate variability (HRV) by acting on autonomic tone with an increase in the vagal activity. The effects of heartfulness meditation (HM) on HRV remain poorly defined. We investigated the effects of HM on HRV in a group of 26 healthy subjects. Subjects were regularly practicing this form of meditation on a daily basis. We assessed the HRV and residual HRV (rHRV) at rest and during meditation. We also used as control a period of respiratory rhythm imposed by an auditory signal, with the imposed breathing rhythm being identical to the spontaneous rhythm recorded during meditation. During deep meditation period, the standard deviation of RR intervals (SD), coefficient of variation of RR intervals (CV), and total power (TP) were decreased while the low-frequency power (LFP), normalized LFP (nLFP), and normalized residual LFP (nrLFP) were increased as compared with those at rest, suggesting that the global vagal modulation was suppressed while the baroreflex was increased during deep medication. At the end of meditation, the LFP, residual LFP (rLFP), nLFP, nrLFP, low-/high-frequency power ratio (LHR), and residual LHR (rLHR) were increased while the residual very low-frequency power (rVLFP), normalized high-frequency power (nHFP), and normalized residual HFP (nrHFP) were decreased, as compared with those during paced breathing, suggesting that the vagal modulation was decreased while the sympathetic modulation was increased by deep meditation. During paced breathing period, the SD, CV, TP, LFP, rLFP, nLFP, nrLFP, LHR, and rLHR were decreased while nHFP and nrHFP were increased as compared with at rest, suggesting that paced breathing could suppress the sympathetic modulation and enhance the vagal modulation. HM can induce a suppression of global vagal modulation and increased the sympathetic modulation and baroreflex. In addition, paced breathing can suppress the sympathetic modulation and enhance the vagal modulation. Unlike studies using other types of meditation, we did not identify evidence of increased vagal tone during HM.
10.3389/fcvm.2019.00062
An electrophysiological investigation on the emotion regulatory mechanisms of brief open monitoring meditation in novice non-meditators.
Lin Yanli,Gloe Lilianne M,Louis Courtney C,Eckerle William D,Fisher Megan E,Moser Jason S
Scientific reports
Despite a growing literature supporting the salutary effects of mindfulness meditation on emotion regulation, the underlying mechanisms linking neural and subjective changes occurring during the actual practice of meditation with emotion regulatory effects observed after meditation remains virtually unexplored. The current study sought to address this gap in knowledge by testing the hypothesis that adoption of internally-directed focused attention, indexed by increased alpha and theta spectral power, during brief open monitoring (OM) mindfulness meditation predicts reduced emotional reactivity, as measured by the late positive potential (LPP). Results revealed that the OM meditation did not produce demonstrable differences in alpha and theta power but did increase self-reported sleepiness relative to controls. Follow-up analyses showed that sleepiness uniquely moderated the effect of meditation on the LPP, such that less sleepiness during meditation, but not the control audio, corresponded to smaller LPPs to negative images. Change in theta, but not alpha power, between meditation and rest was positively correlated with the LPP even after controlling for sleepiness. Although the primary hypothesis was unsupported, the findings demonstrate that phenomenological and neural changes occurring during OM meditation may modulate its subsequent "off-the-cushion" effects on emotional reactivity.
10.1038/s41598-020-71122-7
Advanced Meditation Alters Resting-State Brain Network Connectivity Correlating With Improved Mindfulness.
Vishnubhotla Ramana V,Radhakrishnan Rupa,Kveraga Kestas,Deardorff Rachael,Ram Chithra,Pawale Dhanashri,Wu Yu-Chien,Renschler Janelle,Subramaniam Balachundhar,Sadhasivam Senthilkumar
Frontiers in psychology
The purpose of this study was to investigate the effect of an intensive 8-day Samyama meditation program on the brain functional connectivity using resting-state functional MRI (rs-fMRI). Thirteen Samyama program participants (meditators) and 4 controls underwent fMRI brain scans before and after the 8-day residential meditation program. Subjects underwent fMRI with a blood oxygen level dependent (BOLD) contrast at rest and during focused breathing. Changes in network connectivity before and after Samyama program were evaluated. In addition, validated psychological metrics were correlated with changes in functional connectivity. Meditators showed significantly increased network connectivity between the salience network (SN) and default mode network (DMN) after the Samyama program ( < 0.01). Increased connectivity within the SN correlated with an improvement in self-reported mindfulness scores ( < 0.01). Samyama, an intensive silent meditation program, favorably increased the resting-state functional connectivity between the salience and default mode networks. During focused breath watching, meditators had lower intra-network connectivity in specific networks. Furthermore, increased intra-network connectivity correlated with improved self-reported mindfulness after Samyama. [https://clinicaltrials.gov], Identifier: [NCT04366544]. Registered on 4/17/2020.
10.3389/fpsyg.2021.745344
Functional brain mapping of the relaxation response and meditation.
Lazar S W,Bush G,Gollub R L,Fricchione G L,Khalsa G,Benson H
Neuroreport
Meditation is a conscious mental process that induces a set of integrated physiologic changes termed the relaxation response. Functional magnetic resonance imaging (fMRI) was used to identify and characterize the brain regions that are active during a simple form of meditation. Significant (p<10(-7)) signal increases were observed in the group-averaged data in the dorsolateral prefrontal and parietal cortices, hippocampus/parahippocampus, temporal lobe, pregenual anterior cingulate cortex, striatum, and pre- and post-central gyri during meditation. Global fMRI signal decreases were also noted, although these were probably secondary to cardiorespiratory changes that often accompany meditation. The results indicate that the practice of meditation activates neural structures involved in attention and control of the autonomic nervous system.
Meditation acutely improves psychomotor vigilance, and may decrease sleep need.
Kaul Prashant,Passafiume Jason,Sargent Craig R,O'Hara Bruce F
Behavioral and brain functions : BBF
BACKGROUND:A number of benefits from meditation have been claimed by those who practice various traditions, but few have been well tested in scientifically controlled studies. Among these claims are improved performance and decreased sleep need. Therefore, in these studies we assess whether meditation leads to an immediate performance improvement on a well validated psychomotor vigilance task (PVT), and second, whether longer bouts of meditation may alter sleep need. METHODS:The primary study assessed PVT reaction times before and after 40 minute periods of mediation, nap, or a control activity using a within subject cross-over design. This study utilized novice meditators who were current university students (n = 10). Novice meditators completed 40 minutes of meditation, nap, or control activities on six different days (two separate days for each condition), plus one night of total sleep deprivation on a different night, followed by 40 minutes of meditation.A second study examined sleep times in long term experienced meditators (n = 7) vs. non-meditators (n = 23). Experienced meditators and controls were age and sex matched and living in the Delhi region of India at the time of the study. Both groups continued their normal activities while monitoring their sleep and meditation times. RESULTS:Novice meditators were tested on the PVT before each activity, 10 minutes after each activity and one hour later. All ten novice meditators improved their PVT reaction times immediately following periods of meditation, and all but one got worse immediately following naps. Sleep deprivation produced a slower baseline reaction time (RT) on the PVT that still improved significantly following a period of meditation. In experiments with long-term experienced meditators, sleep duration was measured using both sleep journals and actigraphy. Sleep duration in these subjects was lower than control non-meditators and general population norms, with no apparent decrements in PVT scores. CONCLUSIONS:These results suggest that meditation provides at least a short-term performance improvement even in novice meditators. In long term meditators, multiple hours spent in meditation are associated with a significant decrease in total sleep time when compared with age and sex matched controls who did not meditate. Whether meditation can actually replace a portion of sleep or pay-off sleep debt is under further investigation.
10.1186/1744-9081-6-47
Influence of meditation on anti-correlated networks in the brain.
Frontiers in human neuroscience
Human experiences can be broadly divided into those that are external and related to interaction with the environment, and experiences that are internal and self-related. The cerebral cortex appears to be divided into two corresponding systems: an "extrinsic" system composed of brain areas that respond more to external stimuli and tasks and an "intrinsic" system composed of brain areas that respond less to external stimuli and tasks. These two broad brain systems seem to compete with each other, such that their activity levels over time is usually anti-correlated, even when subjects are "at rest" and not performing any task. This study used meditation as an experimental manipulation to test whether this competition (anti-correlation) can be modulated by cognitive strategy. Participants either fixated without meditation (fixation), or engaged in non-dual awareness (NDA) or focused attention (FA) meditations. We computed inter-area correlations ("functional connectivity") between pairs of brain regions within each system, and between the entire extrinsic and intrinsic systems. Anti-correlation between extrinsic vs. intrinsic systems was stronger during FA meditation and weaker during NDA meditation in comparison to fixation (without mediation). However, correlation between areas within each system did not change across conditions. These results suggest that the anti-correlation found between extrinsic and intrinsic systems is not an immutable property of brain organization and that practicing different forms of meditation can modulate this gross functional organization in profoundly different ways.
10.3389/fnhum.2011.00183
Breath Rate Variability: A Novel Measure to Study the Meditation Effects.
Soni Rahul,Muniyandi Manivannan
International journal of yoga
CONTEXT:Reliable quantitative measure of meditation is still elusive. Although electroencephalogram (EEG) and heart rate variability (HRV) are known as quantitative measures of meditation, effects of meditation on EEG and HRV may well take long time as these measures are involuntarily controlled. Effect of mediation on respiration is well known; however, quantitative measures of respiration during meditation have not been studied. AIMS:Breath rate variability (BRV) as an alternate measure of meditation even over a short duration is proposed. The main objective of this study is to test the hypothesis that BRV is a simple measure that differentiates between meditators and nonmeditators. SETTINGS AND DESIGN:This was a nonrandomized, controlled trial. Volunteers meditate in their natural habitat during signal acquisition. SUBJECTS AND METHODS:We used Photo-Plythysmo-Gram (PPG) signal acquisition system from BIO-PAC and recorded video of chest and abdomen movement due to respiration during a short meditation (15 min) session for 12 individuals (all males) meditating in a relaxed sitting posture. Seven of the 12 individuals had substantial experience in meditation, while others are controls without any experience in meditation. Respiratory signal from PPG signal was derived and matched with that of the video respiratory signal. This derived respiratory signal is used for calculating BRV parameters in time, frequency, nonlinear, and time-frequency domain. STATISTICAL ANALYSIS USED:First, breath-to-breath interval (BBI) was calculated from the respiration signal, then time domain parameters such as standard deviation of BBI (SDBB), root mean square value of SDBB (RMSSD), and standard deviation of SDBB (SDSD) were calculated. We performed spectral analysis to calculate frequency domain parameters (power spectral density [PSD], power of each band, peak frequency of each band, and normalized frequency) using Burg, Welch, and Lomb-Scargle (LS) method. We calculated nonlinear parameters (sample entropy, approximate entropy, Poincare plot, and Renyi entropy). We calculated time frequency parameters (global PSD, low frequency-high frequency [LF-HF] ratio, and LF-HF power) by Burg LS and wavelet method. RESULTS:The results show that the mediated individuals have high value of SDSD (+24%), SDBB (+29%), and RMSSD (+26%). Frequency domain analysis shows substantial increment in LFHF power (+73%) and LFHF ratio (+33%). Nonlinear parameters such as SD1 and SD2 were also more (>20%) for meditated persons. CONCLUSIONS:As compared to HRV, BRV can provide short-term effect on anatomic nervous system meditation, while HRV shows long-term effects. Improved autonomic function is one of the long-term effects of meditation in which an increase in parasympathetic activity and decrease in sympathetic dominance are observed. In future works, BRV could also be used for measuring stress.
10.4103/ijoy.IJOY_27_17
The effect of meditation on regulation of internal body states.
Khalsa Sahib S,Rudrauf David,Davidson Richard J,Tranel Daniel
Frontiers in psychology
Meditation is commonly thought to induce physiologically quiescent states, as evidenced by decreased autonomic parameters during the meditation practice including reduced heart rate, respiratory rate, blood pressure, skin conductance, and increased alpha activity in the electroencephalogram. Preliminary empirical support for this idea was provided in a case report by Dimsdale and Mills (2002), where it was found that meditation seemed to regulate increased levels of cardiovascular arousal induced by bolus isoproterenol infusions. In that study, while meditating, a self-taught meditator exhibited unexpected decreases in heart rate while receiving moderate intravenous doses of the beta adrenergic agonist isoproterenol. This effect was no longer observed when the individual received isoproterenol infusions while not meditating. The current study was designed to explore this phenomenon empirically in a group of formally trained meditators. A total of 15 meditators and 15 non-meditators individually matched on age, sex, and body mass index were recruited. Participants received four series of infusions in a pseudorandomized order: isoproterenol while meditating (or during a relaxation condition for the non-meditators), isoproterenol while resting, saline while meditating (or during a relaxation condition for the non-meditators), and saline while resting. Heart rate was continuously measured throughout all infusions, and several measures of heart rate were derived from the instantaneous cardiac waveform. There was no evidence at the group or individual level suggesting that meditation reduced the cardiovascular response to isoproterenol, across all measures. These results suggest that meditation is not associated with increased regulation of elevated cardiac adrenergic tone.
10.3389/fpsyg.2015.00924
Mindfulness (Vipassana) meditation: effects on P3b event-related potential and heart rate variability.
Delgado-Pastor Luis Carlos,Perakakis Pandelis,Subramanya Pailoor,Telles Shirley,Vila Jaime
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
The concept of mindfulness is based on Vipassana, a Buddhist meditation technique. The present study examines the physiological indices of attention and autonomic regulation in experienced Vipassana meditators to test the claim that mindfulness is an effective therapeutic tool due to its effects on increasing awareness of present experience and emotional self-regulation. Ten male experienced Vipassana meditators underwent two assessment sessions, one where they practiced Vipassana meditation and another where they rested with no meditation (random thinking). Each meditation/no-meditation session lasted 30 min and was preceded and followed by an auditory oddball task with two tones (standard and target). Event-related potentials to the tones were recorded at the Fz, Cz, and Pz locations. Heart rate variability, derived from an EKG, was recorded continuously during the meditation/no-meditation sessions and during a 5-minute baseline before the task. The Vipassana experts showed greater P3b amplitudes to the target tone after meditation than they did both before meditation and after the no-meditation session. They also showed a larger LF/HF ratio increase during specific Vipassana meditation. These results suggest that expert Vipassana meditators showed increased attentional engagement after meditation and increased autonomic regulation during meditation supporting, at least partially, the two claims concerning the clinical effectiveness of mindfulness.
10.1016/j.ijpsycho.2013.07.006
Increases in Theta Oscillatory Activity During Episodic Memory Retrieval Following Mindfulness Meditation Training.
Nyhus Erika,Engel William Andrew,Pitfield Tomas Donatelli,Vakkur Isabella Marie Wang
Frontiers in human neuroscience
Mindfulness meditation has been shown to improve episodic memory and increase theta oscillations which are known to play a role in episodic memory retrieval. The present study examined the effect of mindfulness meditation on episodic memory retrieval and theta oscillations. Using a longitudinal design, subjects in the mindfulness meditation experimental group who underwent 4 weeks of mindfulness meditation training and practice were compared to a waitlist control group. During the pre-training and post-training experimental sessions, subjects completed the Five Facet Mindfulness Questionnaire (FFMQ) and studied adjectives and either imagined a scene (Place Task) or judged its pleasantness (Pleasant Task). During the recognition test, subjects decided which task was performed with each word ("Old Place Task" or "Old Pleasant Task") or "New." FFMQ scores and source discrimination were greater post-training than pre-training in the mindfulness meditation experimental group. Electroencephalography (EEG) results revealed that for the mindfulness meditation experimental group theta power was greater post-training than pre-training in right frontal and left parietal channels and changes in FFMQ scores correlated with changes in theta oscillations in right frontal channels ( = 20). The present results suggest that mindfulness meditation increases source memory retrieval and theta oscillations in a fronto-parietal network.
10.3389/fnhum.2019.00311
A Critical Analysis on Characterizing the Meditation Experience Through the Electroencephalogram.
Frontiers in systems neuroscience
Meditation practices, originated from ancient traditions, have increasingly received attention due to their potential benefits to mental and physical health. The scientific community invests efforts into scrutinizing and quantifying the effects of these practices, especially on the brain. There are methodological challenges in describing the neural correlates of the subjective experience of meditation. We noticed, however, that technical considerations on signal processing also don't follow standardized approaches, which may hinder generalizations. Therefore, in this article, we discuss the usage of the electroencephalogram (EEG) as a tool to study meditation experiences in healthy individuals. We describe the main EEG signal processing techniques and how they have been translated to the meditation field until April 2020. Moreover, we examine in detail the limitations/assumptions of these techniques and highlight some good practices, further discussing how technical specifications may impact the interpretation of the outcomes. By shedding light on technical features, this article contributes to more rigorous approaches to evaluate the construct of meditation.
10.3389/fnsys.2020.00053
Meditation and the EEG.
West M A
Psychological medicine
Previous research on meditation and the EEG is described, and findings relating to EEG patterns during meditation are discussed. Comparisons of meditation with other altered states are reviewed and it is concluded that, on the basis of existing EEG evidence, there is some reason for differentiating between meditation and drowsing. Research on alpha-blocking and habituation of the blocking response during meditation is reviewed, and the effects of meditation on EEG patterns outside of meditation are described. In conclusion, the need for more precisely formulated research is pointed out.
Meditation-induced psychosis.
Kuijpers H J H,van der Heijden F M M A,Tuinier S,Verhoeven W M A
Psychopathology
BACKGROUND:Meditation is a self-regulatory psychological strategy that is frequently applied in Western as well as non-Western countries for different purposes; little is known about adverse events. SAMPLING AND METHODS:A male patient is described who developed an acute and transient psychosis with polymorphic symptomatology after meditating. A literature search for psychotic states related to meditation was carried out on PubMed, Embase and PsycInfo. RESULTS:In the case presented a diagnosis of acute polymorphic psychotic disorder was made. Other case reports dealt with either a relapse of a pre-existent psychotic disorder or with a brief psychotic reaction in patients without a psychiatric history. CONCLUSION:Meditation can act as a stressor in vulnerable patients who may develop a transient psychosis with polymorphic symptomatology. The syndrome is not culture bound but sometimes classified in culture-bound taxonomies like Qi-gong Psychotic Reaction.
10.1159/000108125
Short-Term Effects of Meditation on Sustained Attention as Measured by fNIRS.
Brain sciences
Cognitive abilities such as attention, memory, processing time, perception, and reasoning can be augmented using some type of intervention. Within the broad range of conventional and unconventional intervention methods used in cognitive enhancement, meditation is one of those that is safe, widely practiced by many since ancient times, and has been shown to reduce stress and improve psychological health and cognitive functioning. Various neuroimaging studies using functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have shown functional and structural changes due to meditation in different types of meditation practices and on various groups of meditators. Recently, a few studies on meditation have used functional near infrared spectroscopy (fNIRS) to study the effects of meditation on cerebral hemodynamics. In this study, we examined the short-term effects of loving-kindness (LK) meditation on sustained attention using behavioral performance measures, physiological outcomes, and cognitive activity as measured by fNIRS in first-time meditators during Stroop color word task (SCWT) performance. Our results indicated that behavioral outcomes, assessed mainly on response time (RT) during SCWT performance, showed a significant decrease after meditation. As expected, physiological measures, primarily pulse pressure (PP) measured after meditation dropped significantly as compared to the before meditation measurement. For the hemodynamic measures of oxygenated-hemoglobin (HbO), deoxygenated-hemoglobin (Hb), and total-hemoglobin (HbT), our findings show significant differences in SCWT performance before and after meditation. Our results suggest that LK meditation can result in improvements in cognitive, physiological, and behavioral outcomes of first-time meditators after a short-term session.
10.3390/brainsci10090608
The Effects of Different Stages of Mindfulness Meditation Training on Emotion Regulation.
Zhang Qin,Wang Zheng,Wang Xinqiang,Liu Lei,Zhang Jing,Zhou Renlai
Frontiers in human neuroscience
This study examined mood enhancement effects from 4-week focusing attention (FA) meditation and 4-week open monitoring (OM) meditation in an 8-week mindfulness training program designed for ordinary individuals. Forty participants were randomly assigned to a training group or a control group. All participants were asked to perform cognitive tasks and subjective scale tests at three time points (pre-, mid-, and post-tests). Compared with the participants in the control group, the participants in the meditation training group showed significantly decreased anxiety, depression, and rumination scores; significantly increased mindfulness scores; and significantly reduced reaction times (RTs) in the incongruent condition for the Stroop task. The present study demonstrated that 8-week mindfulness meditation training could effectively enhance the level of mindfulness and improve emotional states. Moreover, FA meditation could partially improve individual levels of mindfulness and effectively improve mood, while OM meditation could further improve individual levels of mindfulness and maintain a positive mood.
10.3389/fnhum.2019.00208
Quantitative change of EEG and respiration signals during mindfulness meditation.
Ahani Asieh,Wahbeh Helane,Nezamfar Hooman,Miller Meghan,Erdogmus Deniz,Oken Barry
Journal of neuroengineering and rehabilitation
BACKGROUND:This study investigates measures of mindfulness meditation (MM) as a mental practice, in which a resting but alert state of mind is maintained. A population of older people with high stress level participated in this study, while electroencephalographic (EEG) and respiration signals were recorded during a MM intervention. The physiological signals during meditation and control conditions were analyzed with signal processing. METHODS:EEG and respiration data were collected and analyzed on 34 novice meditators after a 6-week meditation intervention. Collected data were analyzed with spectral analysis, phase analysis and classification to evaluate an objective marker for meditation. RESULTS:Different frequency bands showed differences in meditation and control conditions. Furthermore, we established a classifier using EEG and respiration signals with a higher accuracy (85%) at discriminating between meditation and control conditions than a classifier using the EEG signal only (78%). CONCLUSION:Support vector machine (SVM) classifier with EEG and respiration feature vector is a viable objective marker for meditation ability. This classifier should be able to quantify different levels of meditation depth and meditation experience in future studies.
10.1186/1743-0003-11-87
Meditation Interventions for Chronic Disease Populations: A Systematic Review.
Chan Roxane Raffin,Larson Janet L
Journal of holistic nursing : official journal of the American Holistic Nurses' Association
The rapidly growing body of research regarding the use of meditation interventions in chronic disease presents an opportunity to compare outcomes based on intervention content. For this review, meditation interventions were described as those interventions delivered to persons with chronic disease where sitting meditation was the main or only content of the intervention with or without the addition of mindful movement. This systematic review identified 45 individual research studies that examined meditations effect on levels of anxiety, depression, and chronic disease symptoms in persons with chronic disease. Individual studies were assessed based on interventional content, the consistency with which interventions were applied, and the research quality. This study identified seven categories of meditation interventions based on the meditation skills and mindful movement practices that were included in the intervention. Overall, half of the interventions had clearly defined and specific meditation interventions (25/45) and half of the studies were conducted using randomized control trials (24/45).
10.1177/0898010115570363
Effect of Heartfulness cleaning and meditation on heart rate variability.
Arya Narendra Kumar,Singh Kamlesh,Malik Anushree,Mehrotra Rahul
Indian heart journal
BACKGROUND:Meditation has been a key component of eastern spiritual practices. Heartfulness meditation is a unique heart based system with key practices like cleaning and meditation aided by yogic transmission. OBJECTIVE:To study the effects of Heartfulness cleaning and meditation (guided by Heartfulness trainer) on heart rate variability (HRV), blood pressure (BP) and heart rate (HR). METHODS:A total of 30 participants (21 males, 9 females; age range 19-70 years, M = 45.1 years and SD = 12.7 years) participated in the study. HRV, BP and HR were studied before, during and after the three stages of rest, cleaning and meditation. RESULTS:There was significant effect of cleaning and meditation on normalized unit of power in low-frequency band (LFnu) for the three conditions [F (2, 87) = 9.98, p < 0.01] with mean values for baseline being 70.82 ± 14.55, cleaning being 55.62 ± 15.06 and meditation being 55.17 ± 16.63. There was also a significant effect of cleaning and meditation on normalized unit of power in high-frequency band (HFnu) [F (2, 87) = 7.31, p < 0.01] with mean values for baseline being 30.86 ± 16.51, cleaning being 44.37 ± 15.06 and meditation being 44.83 ± 16.63. Significant effect of cleaning and meditation was also seen for LF/HF [F (2, 87) = 4.98, p < 0.01] with mean values for baseline being 3.45 ± 3.40, cleaning being 1.63 ± 1.30 and meditation being 1.82 ± 2.19. CONCLUSION:Heartfulness cleaning and meditation had a positive effect on sympathovagal balance.
10.1016/j.ihj.2018.05.004
Meditation states and traits: EEG, ERP, and neuroimaging studies.
Cahn B Rael,Polich John
Psychological bulletin
Neuroelectric and imaging studies of meditation are reviewed. Electroencephalographic measures indicate an overall slowing subsequent to meditation, with theta and alpha activation related to proficiency of practice. Sensory evoked potential assessment of concentrative meditation yields amplitude and latency changes for some components and practices. Cognitive event-related potential evaluation of meditation implies that practice changes attentional allocation. Neuroimaging studies indicate increased regional cerebral blood flow measures during meditation. Taken together, meditation appears to reflect changes in anterior cingulate cortex and dorsolateral prefrontal areas. Neurophysiological meditative state and trait effects are variable but are beginning to demonstrate consistent outcomes for research and clinical applications. Psychological and clinical effects of meditation are summarized, integrated, and discussed with respect to neuroimaging data.
10.1037/0033-2909.132.2.180
The Effects of Concentrative Meditation on the Electroencephalogram in Novice Meditators.
Clinical EEG and neuroscience
Following investigations into the benefits of meditation on psychological health and well-being, research is now seeking to understand the mechanisms underlying these outcomes. This study aimed to identify natural alpha and theta frequency components during eyes-closed resting and concentrative meditation states and examined their differences within and between two testing sessions. Novice meditators had their EEG recorded during eyes-closed resting and concentrative meditation conditions, before and after engaging in a brief daily concentrative meditation practice for approximately one-month. Separate frequency Principal Components Analyses (f-PCA) yielded four spectral components of interest, congruent between both conditions and sessions: Delta-Theta-Alpha, Low Alpha, High Alpha, and Alpha-Beta. While all four components showed some increase in the meditation condition at the second session, only Low Alpha (∼9.5-10.0 Hz) showed similar increases while resting. These findings support the use of f-PCA as a novel method of data analysis in the investigation of psychophysiological states in meditation.
10.1177/15500594211065897
Measuring a Journey without Goal: Meditation, Spirituality, and Physiology.
BioMed research international
The secular practice of meditation is associated with a range of physiological and cognitive effects, including lower blood pressure, lower cortisol, cortical thickening, and activation of areas of the brain associated with attention and emotion regulation. However, in the context of spiritual practice, these benefits are secondary gains, as the primary aim is spiritual transformation. Despite obvious difficulties in trying to measure a journey without goal, spiritual aspects involved in the practice of meditation should also be addressed by experimental study. This review starts by considering meditation in the form of the relaxation response (a counterpart to the stress response), before contrasting mindfulness research that emphasizes the role of attention and alertness in meditation. This contrast demonstrates how reference to traditional spiritual texts (in this case Buddhist) can be used to guide research questions involving meditation. Further considerations are detailed, along with the proposal that research should triangulate spiritual textual sources, first person accounts (i.e., neurophenomenology), and physiological/cognitive measures in order to aid our understanding of meditation, not only in the secular context of health benefits, but also in the context of spiritual practice.
10.1155/2015/891671
Meditation and blood pressure: a meta-analysis of randomized clinical trials.
Shi Lu,Zhang Donglan,Wang Liang,Zhuang Junyang,Cook Rebecca,Chen Liwei
Journal of hypertension
OBJECTIVES:We meta-analyzed the effect of meditation on blood pressure (BP), including both transcendental meditation and non-transcendental meditation interventions. METHODS:We identified randomized controlled trials (RCTs) that examined the BP responses to meditation interventions through a systematic literature search of the PubMed, ABI/INFORM, MEDLINE, EMBASE, PsycINFO, and CINAHL databases (from January 1980 to October 2015). We meta-analyzed the change in SBP and DBP, stratified by type of meditation (transcendental meditation vs. non-transcendental meditation intervention) and by type of BP measurement [ambulatory BP monitoring (ABPM) vs. non-ABPM measurement]. RESULTS:Nineteen studies met the eligibility criteria. Among the studies using the ABPM measurement, the pooled SBP effect estimate was -2.49 mmHg [95% confidence interval (CI): -7.51, 2.53] for transcendental meditation intervention (statistically insignificant) and -3.77 mmHg (95% CI: -5.33, -2.21) for non-transcendental meditation interventions, whereas the pooled DBP effect estimate was -4.26 mmHg (95% CI: -6.21, -2.31) for transcendental meditation interventions and -2.18 mmHg (95% CI: -4.28, -0.09) for non-transcendental meditation interventions. Among the studies using the non-ABPM measurement, the pooled SBP effect estimate from transcendental meditation interventions was -5.57 mmHg (95% CI: -7.41, -3.73) and was -5.09 mmHg with non-transcendental meditation intervention (95% CI: -6.34, -3.85), whereas the pooled effect size in DBP change for transcendental meditation interventions was -2.86 mmHg (95% CI: -4.27, -1.44) and was -2.57 mmHg (95% CI: -3.36, -1.79) for non-transcendental meditation interventions. CONCLUSION:Non-transcendental meditation may serve as a promising alternative approach for lowering both SBP and DBP. More ABPM-measured transcendental meditation interventions might be needed to examine the benefit of transcendental meditation intervention on SBP reduction.
10.1097/HJH.0000000000001217
Comparative Study of the Impact of Active Meditation Protocol and Silence Meditation on Heart Rate Variability and Mood in Women.
Trivedi Gunjan Y,Patel Vidhi,Shah Meghal H,Dhok Meghana J,Bhoyania Kunal
International journal of yoga
Aim:The aim of this study was to understand the impact of an active meditation protocol on heart rate variability (HRV) and mood in women as compared to breath-focused silence meditation. Materials and Methods:Women experienced two different practices of 20 min each: (a) control group: silence meditation focusing on breath and (b) experiment group: active meditation that included four activities, each lasting for 5 minutes - (1) simple humming, (2) coherent heart-focused breathing with 5s of inhalation and 5s of exhalation, (3) coherent heart-focused breathing while invoking positive emotions, and (4) guided imagery about a preidentified goal. The silence meditation encouraged women to only focus on the breath. The Positive and Negative Affect Scale measured mood before/after the practice ( = 24), and emWavePro device measured HRV parameters for 5 min before/after the practices ( = 18). Statistical data analysis was done using a paired t-test. Results:HRV (specifically, parasympathetic nervous system [PNS]) parameters showed a statistically significant improvement in the experiment group as compared to the control group. There was a statistically significant reduction in negative affect after both the practices, and the increase in positive affect was observed only for the experiment group. Conclusions:The active meditation provides a significant enhancement in mood and HRV parameters related to PNS as compared to silence meditation where the changes in HRV were not consistent and the positive mood did not increase significantly. Future research in this area could explore the impact of such practice for a longer duration and understand the impact of each component of the meditative practices.
10.4103/ijoy.IJOY_18_20
Exploring age-related brain degeneration in meditation practitioners.
Luders Eileen
Annals of the New York Academy of Sciences
A growing body of research suggests that meditation practices are associated with substantial psychological as well as physiological benefits. In searching for the biological mechanisms underlying the beneficial impact of meditation, studies have revealed practice-induced alterations of neurotransmitters, brain activity, and cognitive abilities, just to name a few. These findings not only imply a close link between meditation and brain structure, but also suggest possible modulating effects of meditation on age-related brain atrophy. Given that normal aging is associated with significant loss of brain tissue, meditation-induced growth and/or preservation might manifest as a seemingly reduced brain age in meditators (i.e., cerebral measures characteristic of younger brains). Surprisingly, there are only three published studies that have addressed the question of whether meditation diminishes age-related brain degeneration. This paper reviews these three studies with respect to the brain attributes studied, the analytical strategies applied, and the findings revealed. The review concludes with an elaborate discussion on the significance of existing studies, implications and directions for future studies, as well as the overall relevance of this field of research.
10.1111/nyas.12217
Methodological challenges in meditation research.
Caspi Opher,Burleson Katherine O
Advances in mind-body medicine
Like other complex, multifaceted interventions in medicine, meditation represents a mixture of specific and not-so-specific elements of therapy. However, meditation is somewhat unique in that it is difficult to standardize, quantify, and authenticate for a given sample of research subjects. Thus, it is often challenging to discern its specific effects in order to satisfy the scientific method of causal inferences that underlies evidence-based medicine. Therefore, it is important to consider the key methodological challenges that affect both the design and analysis of meditation research. The goal of this paper is to review those challenges and to offer some practical solutions. Among the challenges discussed are the mismatches between questions and designs, the variability in meditation types, problems associated with meditation implementation, individual differences across meditators, and the impossibility of double-blind, placebo-controlled meditation studies. Among the design solutions offered are aptitude x treatment interaction (ATI) research, mixed quantitative-qualitative methods, and practical (pragmatic) clinical trials. Similar issues and solutions can be applied more generally to the entire domain of mind-body therapies.
Change in physiological signals during mindfulness meditation.
Ahani Asieh,Wahbeh Helane,Miller Meghan,Nezamfar Hooman,Erdogmus Deniz,Oken Barry
International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering
Mindfulness meditation (MM) is an inward mental practice, in which a resting but alert state of mind is maintained. MM intervention was performed for a population of older people with high stress levels. This study assessed signal processing methodologies of electroencephalographic (EEG) and respiration signals during meditation and control condition to aid in quantification of the meditative state. EEG and respiration data were collected and analyzed on 34 novice meditators after a 6-week meditation intervention. Collected data were analyzed with spectral analysis and support vector machine classification to evaluate an objective marker for meditation. We observed meditation and control condition differences in the alpha, beta and theta frequency bands. Furthermore, we established a classifier using EEG and respiration signals with a higher accuracy at discriminating between meditation and control conditions than one using the EEG signal only. EEG and respiration based classifier is a viable objective marker for meditation ability. Future studies should quantify different levels of meditation depth and meditation experience using this classifier. Development of an objective physiological meditation marker will allow the mind-body medicine field to advance by strengthening rigor of methods.
10.1109/NER.2013.6696199
Mindfulness meditation, well-being, and heart rate variability: a preliminary investigation into the impact of intensive Vipassana meditation.
Krygier Jonathan R,Heathers James A J,Shahrestani Sara,Abbott Maree,Gross James J,Kemp Andrew H
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Mindfulness meditation has beneficial effects on brain and body, yet the impact of Vipassana, a type of mindfulness meditation, on heart rate variability (HRV) - a psychophysiological marker of mental and physical health - is unknown. We hypothesised increases in measures of well-being and HRV, and decreases in ill-being after training in Vipassana compared to before (time effects), during the meditation task compared to resting baseline (task effects), and a time by task interaction with more pronounced differences between tasks after Vipassana training. HRV (5-minute resting baseline vs. 5-minute meditation) was collected from 36 participants before and after they completed a 10-day intensive Vipassana retreat. Changes in three frequency-domain measures of HRV were analysed using 2 (Time; pre- vs. post-Vipassana)× 2 (Task; resting baseline vs. meditation) within subjects ANOVA. These measures were: normalised high-frequency power (HF n.u.), a widely used biomarker of parasympathetic activity; log-transformed high frequency power (ln HF), a measure of RSA and required to interpret normalised HF; and Traube-Hering-Mayer waves (THM), a component of the low frequency spectrum linked to baroreflex outflow. As expected, participants showed significantly increased well-being, and decreased ill-being. ln HF increased overall during meditation compared to resting baseline, while there was a time∗task interaction for THM. Further testing revealed that pre-Vipassana only ln HF increased during meditation (vs. resting baseline), consistent with a change in respiration. Post-Vipassana, the meditation task increased HF n.u. and decreased THM compared to resting baseline, suggesting post-Vipassana task-related changes are characterised by a decrease in absolute LF power, not parasympathetic-mediated increases in HF power. Such baroreflex changes are classically associated with attentional load, and our results are interpreted in light of the concept of 'flow' - a state of positive and full immersion in an activity. These results are also consistent with changes in normalised HRV reported in other meditation studies.
10.1016/j.ijpsycho.2013.06.017
[The impact of mindfulness meditation on anger].
Hirano Misa,Yukawa Shintaro
Shinrigaku kenkyu : The Japanese journal of psychology
This study explores the impact of mindfulness meditation on anger. A meditation group (N = 37) attended 5-10 minutes of mindfulness meditation daily for a week. They were assessed with self-report scales measuring three aspects of anger (rumination, arousal, and lengthiness) before, just after, and four weeks after their one-week participation. Their scores were compared to a control group (N = 27), which was assessed at the same intervals as the meditation group. The meditation group was also asked to evaluate their current mood using the Affect Grid before and after each meditation. The results indicated that participants in the meditation group who continued meditation voluntarily after the week of their participation had decreased anger rumination scores just after and four weeks after their participation. Additionally, the pleasant score on the Affect Grid increased after meditation for almost all the participation days. These findings suggest the efficacy of mindfulness meditation on improving the tendency to ruminate about anger episodes in the medium-term to long-term, and also on improving mood in the short-term.
Meditation can reduce habitual responding.
Wenk-Sormaz Heidi
Alternative therapies in health and medicine
CONTEXT:Although cognitive aspects of meditation underlie much of its clinical application, very little research has examined meditation's cognitive consequences. This investigation provides experimental support for the idea that meditation leads to a reduction in habitual responding using randomly selected subjects, a secular form of meditation, and a full experimental design. OBJECTIVE:To test the hypothesis that meditation leads to a reduction in habitual responding. DESIGN:Studies 1 and 2 each incorporated pre-test and post-test designs with a 20-minute intervening attention task (meditation, rest, or a cognitive control). SETTING:Yale University in New Haven, Conn, and the University of California, Berkeley. PARTICIPANTS:One hundred and twenty and 90 undergraduates participated in Studies 1 and 2, respectively. MAIN OUTCOME MEASURES:Stroop and Word Production (category generation and stem-completion) tasks assessed habitual responding in Study 1. Galvanic Skin response measured arousal in Study 1. The category generation task assessed habitual responding in Study 2. Tellegen's Absorption Scale (TAS) measured attention ability. RESULTS:In Study 1, meditation participants showed a reduction in habitual responding on the Stroop task as compared to controls. Study 1 revealed no statistically significant effects in the word production task. Stroop task performance was not mediated by arousal reduction. In Study 2, meditation participants showed a reduction in habitual responding on the category production task. Specifically, when participants generated either typical or atypical items, on average, meditation participants produced more atypical items than controls. Category production performance was not mediated by Tellegen's Absorption Scale (TAS) scores. Overall, high TAS scores were related to atypical responding. CONCLUSION:Across cognitive tasks, when participants understood that the goal was to respond non-habitually, meditation reduced habitual responding.
Neural correlates of mindfulness meditation-related anxiety relief.
Zeidan Fadel,Martucci Katherine T,Kraft Robert A,McHaffie John G,Coghill Robert C
Social cognitive and affective neuroscience
Anxiety is the cognitive state related to the inability to control emotional responses to perceived threats. Anxiety is inversely related to brain activity associated with the cognitive regulation of emotions. Mindfulness meditation has been found to regulate anxiety. However, the brain mechanisms involved in meditation-related anxiety relief are largely unknown. We employed pulsed arterial spin labeling MRI to compare the effects of distraction in the form of attending to the breath (ATB; before meditation training) to mindfulness meditation (after meditation training) on state anxiety across the same subjects. Fifteen healthy subjects, with no prior meditation experience, participated in 4 d of mindfulness meditation training. ATB did not reduce state anxiety, but state anxiety was significantly reduced in every session that subjects meditated. Meditation-related anxiety relief was associated with activation of the anterior cingulate cortex, ventromedial prefrontal cortex and anterior insula. Meditation-related activation in these regions exhibited a strong relationship to anxiety relief when compared to ATB. During meditation, those who exhibited greater default-related activity (i.e. posterior cingulate cortex) reported greater anxiety, possibly reflecting an inability to control self-referential thoughts. These findings provide evidence that mindfulness meditation attenuates anxiety through mechanisms involved in the regulation of self-referential thought processes.
10.1093/scan/nst041
EEG-guided meditation: A personalized approach.
Fingelkurts Andrew A,Fingelkurts Alexander A,Kallio-Tamminen Tarja
Journal of physiology, Paris
The therapeutic potential of meditation for physical and mental well-being is well documented, however the possibility of adverse effects warrants further discussion of the suitability of any particular meditation practice for every given participant. This concern highlights the need for a personalized approach in the meditation practice adjusted for a concrete individual. This can be done by using an objective screening procedure that detects the weak and strong cognitive skills in brain function, thus helping design a tailored meditation training protocol. Quantitative electroencephalogram (qEEG) is a suitable tool that allows identification of individual neurophysiological types. Using qEEG screening can aid developing a meditation training program that maximizes results and minimizes risk of potential negative effects. This brief theoretical-conceptual review provides a discussion of the problem and presents some illustrative results on the usage of qEEG screening for the guidance of mediation personalization.
10.1016/j.jphysparis.2015.03.001
Is meditation always relaxing? Investigating heart rate, heart rate variability, experienced effort and likeability during training of three types of meditation.
Lumma Anna-Lena,Kok Bethany E,Singer Tania
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Meditation is often associated with a relaxed state of the body. However, meditation can also be regarded as a type of mental task and training, associated with mental effort and physiological arousal. The cardiovascular effects of meditation may vary depending on the type of meditation, degree of mental effort, and amount of training. In the current study we assessed heart rate (HR), high-frequency heart rate variability (HF-HRV) and subjective ratings of effort and likeability during three types of meditation varying in their cognitive and attentional requirements, namely breathing meditation, loving-kindness meditation and observing-thoughts meditation. In the context of the ReSource project, a one-year longitudinal mental training study, participants practiced each meditation exercise on a daily basis for 3 months. As expected HR and effort were higher during loving-kindness meditation and observing-thoughts meditation compared to breathing meditation. With training over time HR and likeability increased, while HF-HRV and the subjective experience of effort decreased. The increase in HR and decrease in HF-HRV over training was higher for loving-kindness meditation and observing-thoughts meditation compared to breathing meditation. In contrast to implicit beliefs that meditation is always relaxing and associated with low arousal, the current results show that core meditations aiming at improving compassion and meta-cognitive skills require effort and are associated with physiological arousal compared to breathing meditation. Overall these findings can be useful in making more specific suggestions about which type of meditation is most adaptive for a given context and population.
10.1016/j.ijpsycho.2015.04.017
Occipital gamma activation during Vipassana meditation.
Cognitive processing
Long-term Vipassana meditators sat in meditation vs. a control rest (mind-wandering) state for 21 min in a counterbalanced design with spontaneous EEG recorded. Meditation state dynamics were measured with spectral decomposition of the last 6 min of the eyes-closed silent meditation compared to control state. Meditation was associated with a decrease in frontal delta (1-4 Hz) power, especially pronounced in those participants not reporting drowsiness during meditation. Relative increase in frontal theta (4-8 Hz) power was observed during meditation, as well as significantly increased parieto-occipital gamma (35-45 Hz) power, but no other state effects were found for the theta (4-8 Hz), alpha (8-12 Hz), or beta (12-25 Hz) bands. Alpha power was sensitive to condition order, and more experienced meditators exhibited no tendency toward enhanced alpha during meditation relative to the control task. All participants tended to exhibit decreased alpha in association with reported drowsiness. Cross-experimental session occipital gamma power was the greatest in meditators with a daily practice of 10+ years, and the meditation-related gamma power increase was similarly the strongest in such advanced practitioners. The findings suggest that long-term Vipassana meditation contributes to increased occipital gamma power related to long-term meditational expertise and enhanced sensory awareness.
10.1007/s10339-009-0352-1
Hemodynamic changes during long meditation.
Solberg Erik E,Ekeberg Oivind,Holen Are,Ingjer Frank,Sandvik Leiv,Standal Per A,Vikman Agneta
Applied psychophysiology and biofeedback
Changes in heart rate (HR) and blood pressure (BP) in advanced male meditators during 1 hr of meditation were compared with matched control participants resting for 1 hr. Also, changes in HR and BP during 3-hr meditation were analyzed. HR was recorded continuously during meditation (n = 38) and the control rest (n = 21). BP was measured before and after the meditation (n = 44) and the rest (n = 30). During the first hour, HR declined more in the meditators than the controls (p < .01). Within participant variability of HR was significantly lower during meditation than rest (p < .05). In the second hour of meditation, HR declined further (p = .01). BP was unaffected by either meditation or rest. In conclusion, meditation reduced the level of HR and within participant variability of HR more than rest. HR continued to decline during the second hour of meditation.
10.1023/b:apbi.0000039059.20738.39
Meditation therapy for anxiety disorders.
Krisanaprakornkit T,Krisanaprakornkit W,Piyavhatkul N,Laopaiboon M
The Cochrane database of systematic reviews
BACKGROUND:Anxiety disorders are characterised by long term worry, tension, nervousness, fidgeting and symptoms of autonomic system hyperactivity. Meditation is an age-old self regulatory strategy which is gaining more interest in mental health and psychiatry. Meditation can reduce arousal state and may ameliorate anxiety symptoms in various anxiety conditions. OBJECTIVES:To investigate the effectiveness of meditation therapy in treating anxiety disorders SEARCH STRATEGY:Electronic databases searched include CCDANCTR-Studies and CCDANCTR-References, complementary and alternative medicine specific databases, Science Citation Index, Health Services/Technology Assessment Text database, and grey literature databases. Conference proceedings, book chapters and references were checked. Study authors and experts from religious/spiritual organisations were contacted. SELECTION CRITERIA:Types of studies: Randomised controlled trials. TYPES OF PARTICIPANTS:patients with a diagnosis of anxiety disorders, with or without another comorbid psychiatric condition. Types of interventions: concentrative meditation or mindfulness meditation. Comparison conditions: one or combination of 1) pharmacological therapy 2) other psychological treatment 3) other methods of meditation 4) no intervention or waiting list. Types of outcome: 1) improvement in clinical anxiety scale 2) improvement in anxiety level specified by triallists, or global improvement 3) acceptability of treatment, adverse effects 4) dropout. DATA COLLECTION AND ANALYSIS:Data were independently extracted by two reviewers using a pre-designed data collection form. Any disagreements were discussed with a third reviewer, and the authors of the studies were contacted for further information. MAIN RESULTS:Two randomised controlled studies were eligible for inclusion in the review. Both studies were of moderate quality and used active control comparisons (another type of meditation, relaxation, biofeedback). Anti-anxiety drugs were used as standard treatment. The duration of trials ranged from 3 months (12 weeks) to 18 weeks. In one study transcendental meditation showed a reduction in anxiety symptoms and electromyography score comparable with electromyography-biofeedback and relaxation therapy. Another study compared Kundalini Yoga (KY), with Relaxation/Mindfulness Meditation. The Yale-Brown Obsessive Compulsive Scale showed no statistically significant difference between groups. The overall dropout rate in both studies was high (33-44%). Neither study reported on adverse effects of meditation. AUTHORS' CONCLUSIONS:The small number of studies included in this review do not permit any conclusions to be drawn on the effectiveness of meditation therapy for anxiety disorders. Transcendental meditation is comparable with other kinds of relaxation therapies in reducing anxiety, and Kundalini Yoga did not show significant effectiveness in treating obsessive-compulsive disorders compared with Relaxation/Meditation. Drop out rates appear to be high, and adverse effects of meditation have not been reported. More trials are needed.
10.1002/14651858.CD004998.pub2
Meditation Breath Attention Scores (MBAS): Development and investigation of an internet-based assessment of focused attention during meditation practice.
Frewen Paul,Hargraves Heather,DePierro Jonathan,D'Andrea Wendy,Flodrowski Les
Psychological assessment
Meditation Breath Attention Scores (MBAS) represent a self-report, state measure of focused attention (FA) during the practice of meditation. The MBAS assessment procedure involves sounding a bell at periodic intervals during meditation practice, at which times participants indicate if they were attending toward breathing (scored 1) or if instead they had become distracted (e.g., by mind wandering; scored 0); scores are then tallied to yield participants' MBAS for that meditation. The current study developed and evaluated a fully automated and Internet-based version of MBAS in 1,101 volunteers. Results suggested that: (a) MBAS are internally consistent across bell rings; (b) MBAS total scores exhibit a non-normal distribution identifying subgroups of participants with particularly poor or robust FA during meditation; (c) MBAS decrease linearly with the duration of meditation practices, indicating that participants tend to experience less FA later as opposed to earlier in the meditation; (d) in the case of eyes-open meditation, MBAS are higher when the amount of time between bells is shorter; (e) MBAS correlate with various self-reported subjective experiences occurring during meditation; and (f) MBAS are weakly associated with higher trait mindful "acting with awareness," lesser ADHD-related symptoms of inattentiveness, and estimated minutes of meditation practiced in the past month. In sum, results provide further support for the construct validity of MBAS and serve to further characterize the dynamics of individual differences in FA during meditation. (PsycINFO Database Record
10.1037/pas0000283
Toward a brain theory of meditation.
Raffone Antonino,Marzetti Laura,Del Gratta Cosimo,Perrucci Mauro Gianni,Romani Gian Luca,Pizzella Vittorio
Progress in brain research
The rapidly progressing science of meditation has led to insights about the neural correlates of focused attention meditation (FAM), open monitoring meditation (OMM), compassion meditation (CM) and loving kindness meditation (LKM), in terms of states and traits. However, a unified theoretical understanding of the brain mechanisms involved in meditation-related functions, including mindfulness, is lacking. After reviewing the main forms of meditation and their relationships, the major brain networks and brain states, as well as influential theoretical views of consciousness, we outline a Brain Theory of Meditation (BTM). BTM takes the lead from considerations about the roles of the major brain networks, i.e., the central executive, salience and default mode networks, and their interplay, in meditation, and from an essential energetic limitation of the human brain, such that only up to 1% of the neurons in the cortex can be concurrently activated. The development of the theory is also guided by our neuroscientific studies with the outstanding participation of Theravada Buddhist monks, with other relevant findings in literature. BTM suggests mechanisms for the different forms of meditation, with the down-regulation of brain network activities in FAM, the gating and tuning of network coupling in OMM, and state-related up-regulation effects in CM and LKM. The theory also advances a leftward asymmetry in top-down regulation, and an enhanced inter-hemispheric integration, in meditation states and traits, also with implications for a theoretical understanding of conscious access. Meditation thus provides a meta-function for an efficient brain/mind regulation, and a flexible allocation of highly limited and often constrained (e.g., by negative emotion and mind wandering) brain activity resources, which can be related to mindfulness. Finally, a series of experimental predictions is derived from the theory.
10.1016/bs.pbr.2018.10.028
Molecular mechanisms of meditation.
Jindal Vishal,Gupta Sorab,Das Ritwik
Molecular neurobiology
Meditation is a complex process involving change in cognition, memory, and social and emotional control, and causes improvement in various cardiovascular, neurological, autoimmune, and renal pathologies. Meditation also become widely used in medical and psychological treatment therapies for stress-related physical and mental disorders. But still, biological mechanisms in terms of effect on brain and body are poorly understood. This paper explains the basic changes due to meditation in cerebral cortex, prefrontal area, cingulate gyrus, neurotransmitters, white matter, autonomic nervous system, limbic system, cytokines, endorphins, hormones, etc. The following is a review of the current literature regarding the various neurophysiological mechanisms, neuro-endocrine mechanisms, neurochemical substrates, etc. that underlies the complex processes of meditation.
10.1007/s12035-013-8468-9
[Skin Conductance Feedback Meditation: Evaluation of a Novel Physiology-Assisted Meditation Style].
Hinterberger Thilo,Baierlein Felicitas,Breitenbach Natalie
Complementary medicine research
BACKGROUND:Mindfulness meditation (MM) can be regarded as a practice for calming the mind, while the focus on their breathing can help meditators maintain a state of mindful presence. We have developed and evaluated an alternative method for reaching conscious states of pure being without the aid of a focus of attention. METHODS:Skin conductance feedback was provided in real-time during meditation sessions (SCFM) and the practicability of this novel approach was evaluated. 30 participants - 15 meditation experts and 15 non-meditators - attended 6 sessions of meditation over the course of 3 days; 4 SCFM and 2 ordinary MM sessions were conducted. Each session was evaluated with physiological measures and a feedback questionnaire assessing subjective changes in body-related, emotional, and mental self-perception. RESULTS:On average, 78.3% of the participants felt more integrated and connected, 84.2% perceived themselves as more calm and balanced, and 50% felt vitalized after SCFM sessions, while only 5% or less felt more agitated or depressed after the sessions. SCFM was not significantly different from MM. The positive effect of SCFM correlated positively with mindfulness self-ratings. CONCLUSION:The study demonstrates that SCFM is a viable method for performing a satisfying and consciousness-expanding meditation session.
10.1159/000489342
Meditation-specific prefrontal cortical activation during acem meditation: an fMRI study.
Davanger Svend,Ellingsen Oyvind,Holen Are,Hugdahl Kenneth
Perceptual and motor skills
Some of the most popular meditation practices emphasize a relaxed focus of attention in which thoughts, images, sensations, and emotions may emerge and pass freely without actively controlling or pursuing them. Several recent studies show that meditation activates frontal brain areas associated with attention focusing and physical relaxation. The objective of the present study was to assess whether brain activation during relaxed focusing on a meditation sound could be distinguished from similar, concentrative control tasks. Brain activation was measured with functional magnetic resonance imaging (fMRI) in experienced practitioners of Acem meditation. Bilateral areas of the inferior frontal gyrus (BA47) were significantly more activated during repetition of a meditation sound than during concentrative meditation-like cognitive tasks. Meditation-specific brain activation did not habituate over time, but increased in strength with continuous meditation bouts. These observations suggest that meditation with a relaxed focus of attention may activate distinct areas of the prefrontal cortex, with implications for the understanding of neurobiological correlates of meditation.
10.2466/02.04.22.PMS.111.4.291-306
A Positive Emotional-Based Meditation but Not Mindfulness-Based Meditation Improves Emotion Regulation.
Valim Camila P R A T,Marques Lucas M,Boggio Paulo S
Frontiers in psychology
Among the various strategies for modulating the components of the emotional responses, the cognitive reappraisal and distraction are highlighted in current researches. As indicated in recent studies, the capacity for emotional regulation can be improved by mindfulness meditation practicing. This practice usually offers benefits to people's cognitive functioning and aims to improve a characteristic that is intrinsic to every human being: the ability to turn attention to the present moment. Importantly, positive emotions might also be effective on emotional regulation and several meditation practices make use of it. Thus, we aimed to compare two meditation modalities: one focused on attention only (mindfulness) and another focused-on attention toward positive emotions [Twin Hearts Meditation (THM)]. Ninety healthy subjects without any previous experience in meditation were enrolled in this experiment. Of these participants, 30 were submitted to the mindfulness practice with full attention on the observation of thoughts; 30 to the THM; and 30 to a control group (no meditation practice). After one session of meditation, all the participants completed emotional regulation task judging the valence and arousal of pictures with emotional content. In addition to the behavioral data, the participants' psychophysiological measures were recorded via electrocardiography (ECG). The results demonstrate a greater efficacy of THM in suppressing the negative valence of the negative pictures and amplifying the valence of the positive ones. No effect of meditation was observed for the ECG. Our findings indicate that contemplative meditation (THM) can positively influence the emotion regulation ability, even when performed by non-meditators and only once. However, in mindfulness meditation this same immediate effect was not found. Our findings reveal that faster effects of meditation practices can be obtained by practices that considers either the attentional processing and the positive emotions.
10.3389/fpsyg.2019.00647
Blood pressure response to transcendental meditation: a meta-analysis.
Anderson James W,Liu Chunxu,Kryscio Richard J
American journal of hypertension
BACKGROUND:Prior clinical trials suggest that the Transcendental Meditation technique may decrease blood pressure of normotensive and hypertensive individuals but study-quality issues have been raised. This study was designed to assess effects of Transcendental Meditation on blood pressure using objective quality assessments and meta-analyses. METHODS:PubMed and Cochrane databases through December 2006 and collected publications on Transcendental Meditation were searched. Randomized, controlled trials comparing blood pressure responses to the Transcendental Meditation technique with a control group were evaluated. Primary outcome measures were changes in systolic and diastolic blood pressure after practicing Transcendental Meditation or following control procedures. A specific rating system (0-20 points) was used to evaluate studies and random-effects models were used for meta-analyses. RESULTS:Nine randomized, controlled trials met eligibility criteria. Study-quality scores ranged from low (score, 7) to high (16) with three studies of high quality (15 or 16) and three of acceptable quality (11 or 12). The random-effects meta-analysis model for systolic and diastolic blood pressure, respectively, indicated that Transcendental Meditation, compared to control, was associated with the following changes: -4.7 mm Hg (95% confidence interval (CI), -7.4 to -1.9 mm Hg) and -3.2 mm Hg (95% CI, -5.4 to -1.3 mm Hg). Subgroup analyses of hypertensive groups and high-quality studies showed similar reductions. CONCLUSIONS:The regular practice of Transcendental Meditation may have the potential to reduce systolic and diastolic blood pressure by approximately 4.7 and 3.2 mm Hg, respectively. These are clinically meaningful changes.
10.1038/ajh.2007.65
State Mindfulness During Meditation Predicts Enhanced Cognitive Reappraisal.
Garland Eric L,Hanley Adam,Farb Norman A,Froeliger Brett E
Mindfulness
Putatively, mindfulness meditation involves generation of a state of "nonappraisal", yet, little is known about how mindfulness may influence appraisal processes. We investigated whether the state and practice of mindfulness could enhance cognitive reappraisal. Participants (N = 44; age = 24.44, = 4.00, range 19 - 38, 82.2% female) were randomized to either 1) mindfulness, 2) suppression, or 3) mind-wandering induction training conditions. Cognitive reappraisal was assessed with the Emotion Regulation Questionnaire (ERQ) prior to experimental induction, and state mindfulness was assessed immediately following induction using the Toronto Mindfulness Scale (TMS). Participants practiced their assigned strategy for one week and then were reassessed with the ERQ reappraisal subscale. Participants receiving mindfulness training reported significantly higher levels of state mindfulness than participants in the thought suppression and mind wandering conditions. Although brief mindfulness training did not lead to significantly greater increases in reappraisal than the other two conditions, state mindfulness during mindfulness meditation was prospectively associated with increases in reappraisal. Path analysis revealed that the indirect effect between mindfulness training and reappraisal was significant through state mindfulness. Degree of state mindfulness achieved during the act of mindfulness meditation significantly predicted increases in reappraisal over time, suggesting that mindfulness may promote emotion regulation by enhancing cognitive reappraisal.
10.1007/s12671-013-0250-6
Unwanted effects: Is there a negative side of meditation? A multicentre survey.
Cebolla Ausiàs,Demarzo Marcelo,Martins Patricia,Soler Joaquim,Garcia-Campayo Javier
PloS one
OBJECTIVES:Despite the long-term use and evidence-based efficacy of meditation and mindfulness-based interventions, there is still a lack of data about the possible unwanted effects (UEs) of these practices. The aim of this study was to evaluate the occurrence of UEs among meditation practitioners, considering moderating factors such as the type, frequency, and lifetime duration of the meditation practices. METHODS:An online survey was developed and disseminated through several websites, such as Spanish-, English- and Portuguese-language scientific research portals related to mindfulness and meditation. After excluding people who did not answer the survey correctly or completely and those who had less than two months of meditation experience, a total of 342 people participated in the study. However, only 87 reported information about UEs. RESULTS:The majority of the practitioners were women from Spain who were married and had a University education level. Practices were more frequently informal, performed on a daily basis, and followed by focused attention (FA). Among the participants, 25.4% reported UEs, showing that severity varies considerably. The information requested indicated that most of the UEs were transitory and did not lead to discontinuing meditation practice or the need for medical assistance. They were more frequently reported in relation to individual practice, during focused attention meditation, and when practising for more than 20 minutes and alone. The practice of body awareness was associated with UEs to a lesser extent, whereas focused attention was associated more with UEs. CONCLUSIONS:This is the first large-scale, multi-cultural study on the UEs of meditation. Despite its limitations, this study suggests that UEs are prevalent and transitory and should be further studied. We recommend the use of standardized questionnaires to assess the UEs of meditation practices.
10.1371/journal.pone.0183137
The effects of an internet-based mindfulness meditation intervention on electrophysiological markers of attention.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Evidence suggests that mindfulness meditation training has the potential to train aspects of attention. However, the neurophysiological mechanisms underpinning the attentional benefits from mindfulness remain unclear. This randomized controlled trial examined changes in electrophysiological markers of attention before and after completion of a 6-week internet-based mindfulness intervention. EEG and ERP data were collected from 64 generally healthy, mildly stressed older adults. Participants were randomized to an internet-based mindfulness-based stress reduction course (IMMI), an internet-based health and wellness education course, or a waitlist control condition. Attentional N2 and P3 evoked potentials were derived from active and passive auditory oddball paradigms. Participants in the IMMI group showed significantly greater differences in P3 peak-trough amplitude between the active and passive oddball paradigms at endpoint relative to controls. There were no significant relationships between the intervention and N2 potentials. Our data demonstrate a measurable increase in attentional control when discriminating or directing attention away from auditory stimuli for older adult participants who received mindfulness training. These findings lend support to the use of the P3 as a neurophysiological measure of meditation engagement and intervention efficacy.
10.1016/j.ijpsycho.2020.10.002
Mindfulness Meditation in the Treatment of Chronic Pain.
Neurosurgery clinics of North America
Chronic pain is a leading cause of disability in the United States. Limited efficacy associated with pharmacologic management and surgical interventions in refractory patients has led to further exploration of cognitive and behavioral interventions as both an adjunctive and primary therapeutic modality. Mindfulness-based meditation has shown to be effective in reducing pain in randomized studies of chronic pain patients as well as models of experimentally induced pain in healthy participants. These studies have revealed specific neural mechanisms which may explain both short-term and sustained pain relief associated with mindfulness-based interventions.
10.1016/j.nec.2022.02.005
Mindfulness Meditation for Chronic Pain: Systematic Review and Meta-analysis.
Hilton Lara,Hempel Susanne,Ewing Brett A,Apaydin Eric,Xenakis Lea,Newberry Sydne,Colaiaco Ben,Maher Alicia Ruelaz,Shanman Roberta M,Sorbero Melony E,Maglione Margaret A
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
BACKGROUND:Chronic pain patients increasingly seek treatment through mindfulness meditation. PURPOSE:This study aims to synthesize evidence on efficacy and safety of mindfulness meditation interventions for the treatment of chronic pain in adults. METHOD:We conducted a systematic review on randomized controlled trials (RCTs) with meta-analyses using the Hartung-Knapp-Sidik-Jonkman method for random-effects models. Quality of evidence was assessed using the GRADE approach. Outcomes included pain, depression, quality of life, and analgesic use. RESULTS:Thirty-eight RCTs met inclusion criteria; seven reported on safety. We found low-quality evidence that mindfulness meditation is associated with a small decrease in pain compared with all types of controls in 30 RCTs. Statistically significant effects were also found for depression symptoms and quality of life. CONCLUSIONS:While mindfulness meditation improves pain and depression symptoms and quality of life, additional well-designed, rigorous, and large-scale RCTs are needed to decisively provide estimates of the efficacy of mindfulness meditation for chronic pain.
10.1007/s12160-016-9844-2
Alterations in Brain Structure and Amplitude of Low-frequency after 8 weeks of Mindfulness Meditation Training in Meditation-Naïve Subjects.
Yang Chuan-Chih,Barrós-Loscertales Alfonso,Li Meng,Pinazo Daniel,Borchardt Viola,Ávila César,Walter Martin
Scientific reports
Increasing neuroimaging evidence suggests that mindfulness meditation expertise is related to different functional and structural configurations of the default mode network (DMN), the salience network (SN) and the executive network at rest. However, longitudinal studies observing resting network plasticity effects in brains of novices who started to practice meditation are scarce and generally related to one dimension, such as structural or functional effects. The purpose of this study was to investigate structural and functional brain network changes (e.g. DMN) after 40 days of mindfulness meditation training in novices and set these in the context of potentially altered depression symptomatology and anxiety. We found overlapping structural and functional effects in precuneus, a posterior DMN region, where cortical thickness increased and low-frequency amplitudes (ALFF) decreased, while decreased ALFF in left precuneus/posterior cingulate cortex correlates with the reduction of (CES-D) depression scores. In conclusion, regional overlapping of structural and functional changes in precuneus may capture different components of the complex changes of mindfulness meditation training.
10.1038/s41598-019-47470-4
The limited prosocial effects of meditation: A systematic review and meta-analysis.
Scientific reports
Many individuals believe that meditation has the capacity to not only alleviate mental-illness but to improve prosociality. This article systematically reviewed and meta-analysed the effects of meditation interventions on prosociality in randomized controlled trials of healthy adults. Five types of social behaviours were identified: compassion, empathy, aggression, connectedness and prejudice. Although we found a moderate increase in prosociality following meditation, further analysis indicated that this effect was qualified by two factors: type of prosociality and methodological quality. Meditation interventions had an effect on compassion and empathy, but not on aggression, connectedness or prejudice. We further found that compassion levels only increased under two conditions: when the teacher in the meditation intervention was a co-author in the published study; and when the study employed a passive (waiting list) control group but not an active one. Contrary to popular beliefs that meditation will lead to prosocial changes, the results of this meta-analysis showed that the effects of meditation on prosociality were qualified by the type of prosociality and methodological quality of the study. We conclude by highlighting a number of biases and theoretical problems that need addressing to improve quality of research in this area.
10.1038/s41598-018-20299-z
Effects of Meditation and Mind-Body Exercises on Older Adults' Cognitive Performance: A Meta-analysis.
Chan John S Y,Deng Kanfeng,Wu Jiamin,Yan Jin H
The Gerontologist
BACKGROUND AND OBJECTIVES:Meditation and mind-body exercises are suggested to delay decline or enhance cognitive capabilities in older adults. However, their effectiveness remains uncertain. This study assessed the effectiveness of meditation and mind-body exercises to improve cognition in elderly people aged 60 years or above. Moderator variables were also explored. RESEARCH DESIGN AND METHODS:A databases search (MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane Library, Web of Science, CNKI, and Wangfang) was conducted from the first available date to January 10, 2018. Inclusion criteria include (a) human older adults aged 60 years or above, (b) meditation, Tai Chi, Qigong, or yoga intervention, (c) intervention should be structured, (d) inclusion of a control group, (e) at least one outcome measure of cognition was measured at baseline and post-training, and (f) peer-reviewed journal articles in English or Chinese. RESULTS:Forty-one studies (N = 3,551) were included in the meta-analysis. In general, meditation and mind-body exercises improve cognition in the elderly people (SMD = 0.34, 95% CI: 0.19 to 0.48), but the cognition-enhancing effects depend on the type of exercise. In addition, cognitive performance is only improved when the length of intervention is longer than 12 weeks, exercise frequency is 3-7 times/week, or duration of an exercise session is 45-60 min/session. DISCUSSION AND IMPLICATIONS:This study suggests that meditation and mind-body exercises are effective to improve cognition of older adults aged 60 years or above, and exercise parameters should be considered for intervention planning.
10.1093/geront/gnz022
Respiratory Biofeedback Does Not Facilitate Lowering Arousal in Meditation Through Virtual Reality.
Tinga Angelica M,Nyklíček Ivan,Jansen Michel P,de Back Tycho T,Louwerse Max M
Applied psychophysiology and biofeedback
The current study examined the effectiveness of respiratory biofeedback in lowering subjective and objective arousal after stress. Participants were presented with a meditation session in virtual reality while subjective and objective arousal were measured, the latter measured through ECG and EEG. Three conditions were used: (a) a respiratory biofeedback condition, in which visual feedback was paired to breathing; (b) a control feedback placebo condition, in which visual feedback was not paired to breathing; and (c) a control no-feedback condition, in which no visual feedback was used. Subjective and objective arousal decreased during meditation after stress in all conditions, demonstrating recovery after stress during meditation in virtual reality. However, the reduction in arousal (on all outcome measures combined and heart rate specifically) was largest in the control feedback placebo condition, in which no biofeedback was used, indicating that respiratory biofeedback had no additional value in reducing arousal. The findings of the current study highlight the importance of including a control feedback placebo condition in order to establish the exact additional value of biofeedback and offer insights in applying cost-effective virtual reality meditation training.
10.1007/s10484-018-9421-5
Meditation to improve lateral and divergent thinking among older adults: a 2-year follow-up study.
Pandya Samta P
Aging clinical and experimental research
This article reports a 2-year follow-up study on the effect of meditation to improve lateral and divergent thinking among older adults. Two measures were used with the intervention and control cohorts: Runco Ideational Behavior Scale (RIBS) and Lateral Thinking Disposition Scale (LATD). There was a significant post-test increase in the RIBS and LATD scores of the intervention group. Post-test scores were higher for women, highly qualified, retired, ever-single, widowed or divorced, living solitary or in nonconventional arrangements, in good health, who attended at least 75% of the meditation lessons and regularly practiced at home. Home practice was the strongest predictor of higher post-test scores. Structural equation models indicated that adherence to the intervention by regular attendance and home practice mediated the relationship between demographic predictors and outcomes. Meditation is useful to improve lateral and divergent thinking among older adults with some refinements for sub-cohort-specific issues.
10.1007/s40520-019-01240-4
Blood Pressure Response to Meditation and Yoga: A Systematic Review and Meta-Analysis.
Park Seong-Hi,Han Kuem Sun
Journal of alternative and complementary medicine (New York, N.Y.)
OBJECTIVES:To introduce research that presents scientific evidence regarding the effects of mantra and mindfulness meditation techniques and yoga on decreasing blood pressure (BP) in patients who have hypertension. METHODS:A literature search was performed to identify all studies published between 1946 and 2014 from periodicals indexed in Ovid Medline, EMBASE, CINAHL, PsycINFO, KoreaMed, and NDSL by using the following keywords: "hypertension," "blood pressure," "psychotherapy," "relaxation therapy," "meditation," "yoga," and "mind-body therapy." The Cochrane's Risk of Bias was applied to assess the internal validity of the randomized controlled trial studies. Thirteen studies were analyzed in this meta-analysis by using Review Manager 5.3. RESULTS:Among 510 possible studies, 13 met the selection criteria. Seven examined meditation, and six examined yoga. The meta-analysis indicated that meditation and yoga appeared to decrease both systolic and diastolic BP, which were within similar baseline ranges, and the reduction was statistically significant; however, some results showed little difference. After an in-depth analysis of those results, BP range and patient age were revealed as the factors that affected the different results in some reports. In particular, meditation played a noticeable role in decreasing the BP of subjects older than 60 years of age, whereas yoga seemed to contribute to the decrease of subjects aged less than 60 years. CONCLUSIONS:While acknowledging the limitations of this research due to the differences in BP and the participants' ages, meditation and yoga are demonstrated to be effective alternatives to pharmacotherapy. Given that BP decreased with the use of meditation and yoga, and this effect varied in different age groups, scientifically measured outcomes indicate that these practices are safe alternatives in some cases.
10.1089/acm.2016.0234
Electrophysiological effects of mindfulness meditation in a concentration test.
Morais Pedro,Quaresma Claúdia,Vigário Ricardo,Quintão Carla
Medical & biological engineering & computing
In this paper, we evaluate the effects of mindfulness meditation training in electrophysiological signals, recorded during a concentration task. Longitudinal experiments have been limited to the analysis of psychological scores through depression, anxiety, and stress state (DASS) surveys. Here, we present a longitudinal study, confronting DASS survey data with electrocardiography (ECG), electroencephalography (EEG), and electrodermal activity (EDA) signals. Twenty-five university student volunteers (mean age = 26, SD = 7, 9 male) attended a 25-h mindfulness-based stress reduction (MBSR) course, over a period of 8 weeks. There were four evaluation periods: pre/peri/post-course and a fourth follow-up, after 2 months. All three recorded biosignals presented congruent results, in line with the expected benefits of regular meditation practice. In average, EDA activity decreased throughout the course, -64.5%, whereas the mean heart rate displayed a small reduction, -5.8%, possibly as a result of an increase in parasympathetic nervous system activity. Prefrontal (AF3) cortical alpha activity, often associated with calm conditions, saw a very significant increase, 148.1%. Also, the number of stressed and anxious subjects showed a significant decrease, -92.9% and -85.7%, respectively. Easy to practice and within everyone's reach, this mindfulness meditation can be used proactively to prevent or enhance better quality of life. 25 volunteers attended a Mindfulness-Based Stress Reduction (MBSR) course in 4 evaluation periods: Pre/Peri/Post-course and a fourth follow-up after two months. A Depression, Anxiety and Stress State (DASS) survey is completed in each period. Electrodermal Activity (EDA), Electrocardiography (ECG) and Electroencephalography (EEG) are also recorded and processed. By integrating self-reported surveys and electrophysiological recordings there is strong evidence of evolution in wellbeing. Mindfulness meditation can be used proactively to prevent or enhance better quality of life.
10.1007/s11517-021-02332-y
Effects of Meditation on Mental Health and Cardiovascular Balance in Caregivers.
Díaz-Rodríguez Lourdes,Vargas-Román Keyla,Sanchez-Garcia Juan Carlos,Rodríguez-Blanque Raquel,Cañadas-De la Fuente Guillermo Arturo,De La Fuente-Solana Emilia I
International journal of environmental research and public health
BACKGROUND:Caring for a loved one can be rewarding but is also associated with substantial caregiver burden, developing mental outcomes and affecting happiness. The aim of this study was to determine the effects of a four-week, 16-h presential meditation program on physiological and psychological parameters and vagal nerve activity in high-burden caregivers, as compared to a control group. METHODS:A non-randomized repeated-measures controlled clinical trial was conducted. RESULTS:According to the ANCOVA results, the global happiness score (F = 297.42, < 0.001) and the scores for all subscales were significantly higher in the experimental group than in the control group at 5 weeks. Anxiety levels were also significantly reduced in the experimental group (F = 24.92, < 0.001), systolic (F = 16.23, < 0.001) and diastolic blood (F = 34.39, < 0.001) pressures, and the resting heart rate (F = 17.90, < 0.05). HRV results revealed significant between-group differences in the HRV Index (F = 8.40, < 0.05), SDNN (F = 13.59, < 0.05), and RMSSD (F = 10.72, < 0.05) in the time domain, and HF (F = 4.82 < 0.05)) in the frequency domain, which were all improved in the experimental group after the meditation program. CONCLUSIONS:Meditation can be a useful therapy to enhance the mental health and autonomic nervous system balance of informal caregivers, improving symptoms of physical and mental overload.
10.3390/ijerph18020617
Comparing impacts of meditation training in focused attention, open monitoring, and mindfulness-based cognitive therapy on emotion reactivity and regulation: Neural and subjective evidence from a dismantling study.
Psychophysiology
Commonly conducted mindfulness-based trainings such as Mindfulness-based Stress Reduction (MBSR) and Mindfulness-based Cognitive Therapy (MBCT) highlight training in two key forms of meditation: focused attention (FA) and open monitoring (OM). Largely unknown is what each of these mindfulness practices contributes to emotional and other important training outcomes. This dismantling trial compared the effects of structurally equivalent trainings in MBCT, FA, and OM on neural and subjective markers of emotional reactivity and regulation among community adults, with the aim to better understand which forms of training represent active ingredients in mindfulness trainings. Participants with varying levels of depressive symptoms were randomized to one of the three trainings. Before and after each 8-week training, N = 89 participants completed a modified version of the Emotional Reactivity and Regulation Task while electroencephalographic (EEG) and self-reported emotional responses to negative, positive, and neutral photographic images were collected. Examination of EEG-based frontal alpha band asymmetry during passive viewing (reactivity) and active regulation phases of the task showed that FA and MBCT trainings produced significant leftward hemispheric shifts in frontal alpha asymmetry, commonly associated with a shift toward approach-based positive affect. Self-reported emotional responses to negative images corroborated these results, suggesting salutary changes in both emotional reactivity and regulation. OM training had limited beneficial effects, restricted to the subjective outcomes. The findings suggest that MBCT may derive its greatest benefit from training in FA rather than OM. Discussion highlights the potential value of FA training for emotional health.
10.1111/psyp.14024
Why could meditation practice help promote mental health and well-being in aging?
Chételat Gaël,Lutz Antoine,Arenaza-Urquijo Eider,Collette Fabienne,Klimecki Olga,Marchant Natalie
Alzheimer's research & therapy
Psycho-affective states or traits such as stress, depression, anxiety and neuroticism are known to affect sleep, cognition and mental health and well-being in aging populations and to be associated with increased risk for Alzheimer's disease (AD). Mental training for stress reduction and emotional and attentional regulation through meditation practice might help reduce these adverse factors. So far, studies on the impact of meditation practice on brain and cognition in aging are scarce and have limitations but the findings are encouraging, showing a positive effect of meditation training on cognition, especially on attention and memory, and on brain structure and function especially in frontal and limbic structures and insula. In line with this, we showed in a pilot study that gray matter volume and/or glucose metabolism was higher in six older adult expert meditators compared to 67 age-matched controls in the prefrontal, anterior and posterior cingulate cortex, insula and temporo-parietal junction. These preliminary findings are important in the context of reserve and brain maintenance as they suggest that long-term meditation practice might help preserve brain structure and function from progressive age-related decline. Further studies are needed to confirm these results with larger samples and in randomized controlled trials and to investigate the mechanisms underlying these meditation-related effects. The European Commission-funded project Silver Santé Study will address these challenges by studying 316 older adults including 30 expert meditators and 286 meditation-naïve participants (either cognitively normal or with subjective cognitive decline). Two randomized controlled trials will be conducted to assess the effects of 2-month and 18-month meditation, English learning or health education training programs (versus a passive control) on behavioral, sleep, blood sampling and neuroimaging measures. This European research initiative illustrates the progressive awareness of the benefit of such non-pharmacological approaches in the prevention of dementia and the relevance of taking into account the psycho-affective dimension in endeavoring to improve mental health and well-being of older adults.
10.1186/s13195-018-0388-5
Altered auditory feedback perception following an 8-week mindfulness meditation practice.
Miyashiro Daiki,Toyomura Akira,Haitani Tomosumi,Kumano Hiroaki
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
Our own ongoing motor actions are perceived through sensory feedback pathways, and are integrated with neural processes to modulate further actions. This sensory feedback mechanism is known to contribute to the rehabilitation of impaired motor functions. Recent evidence also suggests that mindfulness meditation improves our awareness to sensation; therefore, enhancement of awareness to sensory feedback through mindfulness meditation training may have potential clinical applications. This study investigated an effect of eight-week practice of mindfulness meditation on speech perception/production processes. Among the thirty healthy participants, half of them engaged in regular meditation practice of 10 min per day for eight weeks, and the other half were not given any instructions for their daily life. The change of speech performance in sentence reading under 200 ms delayed auditory feedback (DAF) condition were assessed compared to without delay condition. Also, event-related potential response to the short sound of /a/, were measured. The result showed that, after the eight-week practice, the meditation group showed significantly improved speech fluency in the DAF condition, when 16-min meditation was introduced before the experiments. Furthermore, significantly increased auditory evoked potentials were observed in the central-parietal region when the participants listened to the delayed auditory feedback sound of their own voice. These findings provide the first glimpses into the possible relationship between mindfulness meditation and auditory feedback. Different instructions for daily activity between the meditation and control groups should be considered in further studies.
10.1016/j.ijpsycho.2019.01.010
Mindfulness Meditation as Adjunctive Therapy to Improve the Glycemic Care and Quality of Life in Patients with Type 1 Diabetes.
Medical sciences (Basel, Switzerland)
BACKGROUND:Mindfulness Meditation (MM) is known to improve glycemic control and enhance the quality of life (QoL) in type 2 diabetes (T2D) patients. Unfortunately, the role of meditation in type 1 diabetes (T1D) has not been studied extensively. Therefore, we conducted this study to determine the effect of MM on the glycemic control and QoL in people living with T1D. METHODOLOGY:Thirty-two adults living with T1D were equally randomized into intervention (meditation) and control groups. The glycemic control and QoL were assessed at the baseline and after six months of intervention. RESULTS:A total of thirty-two adults (15 males, 46.9%; mean age 23.8 ± 6.6 years) with type 1 diabetes (mean diabetes duration 12.7 ± 6.2 years) participated in the study. At the end of six months, a statistically significant improvement was seen in the mean blood glucose level in the control group (222.4 ± 77.8 versus 182.6 ± 52.0; = 0.007) and the intervention group (215.3 ± 50.1 versus 193.2 ± 31.8; = 0.008). Additionally, there was a significant reduction in the total diabetes distress score in the intervention group (1.6 ± 0.3 versus 1.3 ± 0.3; = 0.003), while no change was observed in the control group (1.6 ± 0.7 versus 1.7 ± 0.4; = 0.762). A statistically significant improvement was noticed in the health and functioning domain in the intervention group ( = 0.023). CONCLUSIONS:An improvement in the glycemic control and quality of life of the patients was observed in our study. MM certainly plays an important role in attaining peace of mind and helps patients to channel their energy in a positive direction.
10.3390/medsci9020033
Meditation Monologue can Reduce Clinical Injection-Related Anxiety: Randomized Controlled Trial.
Sugimoto Dai,Slick Nathalie R,Mendel David L,Stein Cynthia J,Pluhar Emily,Fraser Joana L,Meehan William P,Corrado Gianmichel D
Journal of evidence-based integrative medicine
BACKGROUND:Strategies to reduce anxiety prior to injection procedures are not well understood. The purpose is to determine the effect of a meditation monologue intervention delivered via phone/mobile application on pre-injection anxiety levels among patients undergoing a clinical injection. The following hypothesis was tested: patients who listened to a meditation monologue via phone/mobile application prior to clinical injection would experience less anxiety compared to those who did not. METHODS:A prospective, randomized controlled trial was performed at an orthopedics and sports medicine clinic of a tertiary level medical center in the New England region, USA. Thirty patients scheduled for intra- or peri-articular injections were randomly allocated to intervention (meditation monologue) or placebo (nature sounds) group. Main outcome variables were state and trait anxiety inventory (STAI) scores and blood pressure (BP), heart rate, and respiratory rate. RESULTS:There were 16 participants who were allocated to intervention (meditation monologue) while 14 participants were assigned to placebo (nature sounds). There was no interaction effect. However, a main time effect was found. Both state anxiety (STAI-S) and trait anxiety (STAI-T) scores were significantly reduced post-intervention compared to pre-intervention (STAI-S: p = 0.04, STAI-T: p = 0.04). Also, a statistically significant main group effect was detected. The pre- and post- STAI-S score reduction was greater in the intervention group (p = 0.028). Also, a significant diastolic BP increase between pre- and post-intervention was recorded in the intervention group (p = 0.028), but not in the placebo group (p = 0.999). CONCLUSION:Listening to a meditation monologue via phone/mobile application prior to clinical injection can reduce anxiety in adult patients receiving intra- and peri-articular injections. ClinicalTrials.gov NCT02690194.
10.1177/2515690X211006031
Acute effects of meditation training on the waking and sleeping brain: Is it all about homeostasis?
Dentico Daniela,Bachhuber David,Riedner Brady A,Ferrarelli Fabio,Tononi Giulio,Davidson Richard J,Lutz Antoine
The European journal of neuroscience
Our recent finding of a meditation-related increase in low-frequency NREM sleep EEG oscillatory activities peaking in the theta-alpha range (4-12 Hz) was not predicted. From a consolidated body of research on sleep homeostasis, we would expect a change peaking in slow wave activity (1-4 Hz) following an intense meditation session. Here we compared these changes in sleep with the post-meditation changes in waking rest scalp power to further characterize their functional significance. High-density EEG recordings were acquired from 27 long-term meditators (LTM) on three separate days at baseline and following two 8-hr sessions of either mindfulness or compassion-and-loving-kindness meditation. Thirty-one meditation-naïve participants (MNP) were recorded at the same time points. As a common effect of meditation practice, we found increases in low and fast waking EEG oscillations for LTM only, peaking at eight and 15 Hz respectively, over prefrontal, and left centro-parietal electrodes. Paralleling our previous findings in sleep, there was no significant difference between meditation styles in LTM as well as no difference between matched sessions in MNP. Meditation-related changes in wakefulness and NREM sleep were correlated across space and frequency. A significant correlation was found in the EEG low frequencies (<12 Hz). Since the peak of coupling was observed in the theta-alpha oscillatory range, sleep homeostatic response to meditation practice is not sufficient to explain our findings. Another likely phenomenon into play is a reverberation of meditation-related processes during subsequent sleep. Future studies should ascertain the interplay between these processes in promoting the beneficial effects of meditation practice.
10.1111/ejn.14131
Breath Versus Emotions: The Impact of Different Foci of Attention During Mindfulness Meditation on the Experience of Negative and Positive Emotions.
Beblo Thomas,Pelster Sarah,Schilling Christine,Kleinke Kristian,Iffland Benjamin,Driessen Martin,Fernando Silvia
Behavior therapy
Mindfulness meditation yields beneficial effects on the processing of emotions. However, it is still unclear whether the focus of attention during meditation influences these effects. In the present study we aimed at comparing the effects of breathing meditation and emotion-focused meditation on the immediate and delayed processing of negative and positive emotions. The study included 65 adult novice meditators who were exposed to positively and negatively valenced film clips. Participants were randomly assigned to three conditions. While watching the films at t1, they were asked to mindfully focus on their breath (condition 1), on emotions (condition 2), or on nothing in particular (condition 3). Ten minutes later at t2, comparable film clips were shown but all participants watched them without taking up a mindful attitude. Dependent measures were emotional states at t1 and t2. Participants of both meditation conditions particularly showed a more preferable delayed emotional reaction to negative stimuli than participants of the control condition. Breathing meditation and emotion-focused meditation may constitute effective emotion regulation strategies to deal with negatively valenced emotional states.
10.1016/j.beth.2017.12.006
Effects of Transcendental Meditation on Blood Pressure: A Meta-analysis.
The Journal of cardiovascular nursing
BACKGROUND:The World Health Organization estimates that 1.13 billion people worldwide have hypertension. Although pharmaceutical management of blood pressure is available, there are reasons why people prefer not to take medications including costs, adverse effects, and lack of access. Nonpharmacological healthy lifestyle methods are needed. One alternative method is transcendental meditation (TM). OBJECTIVE:The purpose of this study was to quantitatively synthesize the effects of TM on blood pressure. In addition, we examined the moderator effects of participant, methods, and intervention characteristics. METHODS:We searched 19 electronic databases without date restrictions to March 2021 including the gray literature and specific journals for primary studies evaluating TM to reduce blood pressure in adults and written in English. We coded primary studies for 5 categories (source, method, intervention, participant characteristics, and outcomes). RESULTS:Across 18 primary studies (N = 1207), TM mildly improved systolic blood pressure by -3.3 mm Hg (P = .025) and diastolic blood pressure by -1.8 mm Hg (P = .008) compared with comparison groups, but the effects waned after 3 months. Transcendental meditation reduced systolic blood pressure in samples that were 65 years and older significantly more than in samples that were younger than 65 years (-1.44 vs -9.87, P = .021) but showed no differential effect on diastolic blood pressure. CONCLUSIONS:Transcendental meditation mildly reduced blood pressure, but the effect waned after 3 months. Adults older than 65 years benefited more than younger adults. Transcendental meditation might be recommended as one aspect of a healthy lifestyle.
10.1097/JCN.0000000000000849
Exploration of psychological mechanisms of the reduced stress response in long-term meditation practitioners.
Gamaiunova Liudmila,Brandt Pierre-Yves,Bondolfi Guido,Kliegel Matthias
Psychoneuroendocrinology
Previous research links contemplative practices, such as meditation, with stress reduction. However, little is known about the psychological mechanisms underlying this relationship. This study compares the physiological stress response (reactivity and recovery) measured by changes in salivary cortisol, heart rate, heart rate variability, and the associated stress-related ratings in long-term meditation practitioners (N = 29) and age- and sex- matched meditation naïve controls (N = 26). The participants were administered the Trier Social Stress Test in its active and placebo versions. The results demonstrated that long-term meditation practitioners had faster cortisol recovery from stress, and experienced less shame and higher self-esteem after the exposure to social-evaluative threat. In addition, long-term meditation practitioners scored higher on adaptive cognitive emotion regulation strategies, such as acceptance and positive reappraisal, and lower on maladaptive ones, such as catastrophizing. The cognitive emotion regulation strategy of acceptance mediated the relationship between meditation practice and cortisol recovery. These results suggest that meditation practice is associated with faster recovery from stress due to the employment of adaptive emotion regulation strategy of acceptance, delineating a pathway underlying the positive effects of meditation on stress.
10.1016/j.psyneuen.2019.02.026
P300 and Heart Rate Variability Recorded Simultaneously in Meditation.
Telles Shirley,Singh Deepeshwar,Naveen K V,Pailoor Subramanya,Singh Nilkamal,Pathak Shivangi
Clinical EEG and neuroscience
Sympathetic activation is required for attention. Separate studies have shown that meditation ( a) improves attention and ( b) reduces sympathetic activity. The present study assessed attention with the P300 and sympathetic activity with heart rate variability (HRV). Forty-seven male subjects (group mean age ± SD, 21.6 ± 3.4 years) were assessed in 4 mental states: ( a) random thinking, ( b) nonmeditative focusing, ( c) meditative focusing, and ( d) defocused meditation. These were recorded on 4 consecutive days. HRV, respiration, and P300 event-related potentials (ERPs) were recorded before and after the sessions. Data were analyzed with repeated-measures analysis of variance followed by post hoc analysis. HRV showed a significant increase in low-frequency (LF) power, decrease in high-frequency (HF) power and an increase in average heart rate based on the average R-R interval after meditative focusing, compared with before. In contrast, the average heart rate decreased after defocused meditation compared with before. There was a significant increase in the P300 peak amplitude after meditative focusing and defocused meditation, with a reduction in peak latency after defocused meditation. These results suggest that after meditation with focusing, there was sympathetic arousal whereas after defocused meditation, there was a decrease in the average heart rate while participants carried out the P300 auditory oddball task sooner.
10.1177/1550059418790717
Combining Behavior and EEG to Study the Effects of Mindfulness Meditation on Episodic Memory.
Nyhus Erika,Engel William A,Pitfield Tomas Donatelli,Vakkur Isabella M W
Journal of visualized experiments : JoVE
Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has examined the behavioral and neural effects of mindfulness meditation on episodic memory. Here we present a protocol that combines mindfulness meditation training, an episodic memory task, and EEG to examine how mindfulness meditation changes behavioral performance and the neural correlates of episodic memory. Subjects in a mindfulness meditation experimental group were compared to a waitlist control group. Subjects in the mindfulness meditation experimental group spent four weeks training and practicing mindfulness meditation. Mindfulness was measured before and after training using the Five Facet Mindfulness Questionnaire (FFMQ). Episodic memory was measured before and after training using a source recognition task. During the retrieval phase of the source recognition task, EEG was recorded. The results showed that mindfulness, source recognition behavioral performance, and EEG theta power in right frontal and left parietal channels increased following mindfulness meditation training. In addition, increases in mindfulness correlated with increases in theta power in right frontal channels. Therefore, results obtained from combining mindfulness meditation training, an episodic memory task, and EEG reveal the behavioral and neural effects of mindfulness meditation on episodic memory.
10.3791/61247
A novel approach to improve stress regulation among traumatized youth in residential care: Feasibility study testing three game-based meditation interventions.
Schuurmans Angela A T,Nijhof Karin S,Scholte Ron,Popma Arne,Otten Roy
Early intervention in psychiatry
AIM:Many youth in residential care suffer from post-traumatic symptoms that have adverse effects on a range of psychological, behavioural and physiological outcomes. Although current evidence-based treatment options are effective, they have their limitations. Meditation interventions are an alternative to traditional trauma-focused treatment. This pilot study aimed to evaluate three game-based meditation interventions in a sample of traumatized youth in residential care. METHODS:Fifteen participants were randomly divided over three conditions (Muse, DayDream and Wild Divine) that all consisted of twelve 15-minute game-play sessions. Physiological measurements (heart rate variability) were conducted at baseline, post-treatment and during each intervention session. Post-traumatic symptoms, stress, depression, anxiety and aggression were assessed at baseline, post-treatment and 1-month follow-up. RESULTS:Physiological stress regulation was improved during the meditation sessions of all three interventions. User evaluations were in particular high for Muse with a rating of 8.42 out of 10 for game evaluation. Overall, outcomes on psychopathology demonstrated the most robust effect on stress. Muse performed best, with all participants showing reliable improvements (reliable change indexes [RCIs]) in post-traumatic symptoms, stress and anxiety. Participants who played Daydream or Wild Divine showed inconsistent progression: some participants improved, whereas others remained stable or even deteriorated based on their RCIs. CONCLUSIONS:Preliminary findings show promising outcomes on physiology, psychopathology and user evaluations. All indicate the potential of this innovative form of stress regulation intervention, and the potential of Muse in particular, although findings should be considered preliminary due to our small sample size. Further studies are warranted to assess intervention effectiveness effects of Muse or other game-based meditation interventions for traumatized youth.
10.1111/eip.12874
Meditation and Endocrine Health and Wellbeing.
Pascoe Michaela C,Thompson David R,Ski Chantal F
Trends in endocrinology and metabolism: TEM
Meditation is a popular practice for reducing stress and improving mental health and wellbeing. Its effects are mediated largely by the endocrine system, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid axis, and the renin-angiotensin-aldosterone system, and energy homeostasis. The limited evidence available indicates that changes associated with endocrine function following meditation correspond with improvements in mental health. However, this field of study is hampered by a lack of consensus as to definition and types of meditation and the mixed quality of reported studies. Moreover, the exact mechanisms by which meditation operates remain unclear and more robust studies are required to explore this by delineating the target populations, forms, dosages, and modes of delivery of meditation, comparison groups, and health experiences and outcomes used.
10.1016/j.tem.2020.01.012
Effect of one-session focused attention meditation on the working memory capacity of meditation novices: A functional near-infrared spectroscopy study.
Yamaya Noriki,Tsuchiya Kenji,Takizawa Ibuki,Shimoda Kaori,Kitazawa Kazuki,Tozato Fusae
Brain and behavior
INTRODUCTION:Previous studies have revealed that one-session focused attention meditation (FAM) can improve top-down attention control, which is one of the factors of working memory capacity (WMC). In addition, FAM shares various neural substrates, including the dorsolateral prefrontal cortex (DLPFC), with WMC. Thus, we hypothesized that one-session FAM would improve WMC by activating the DLPFC evoked by the top-down attention control. In this study, we examined whether FAM modified WMC in individuals with little to no meditation experience. METHODS:The participants were randomly assigned to either the FAM group (N = 13) or the control group (N = 17) who engaged in random thinking (i.e., mind-wandering). Before and after each 15-min intervention, the participants' WMC was measured according to the total number of correct answers in the Reading Span Test. During each intervention, functional near-infrared spectroscopy was employed to measure the blood flow in the participants' DLPFC and determine the top-down attention control effect. RESULTS:In the FAM group, WMC increased, and the bilateral DLPFC was activated during the intervention. As for the control group, WMC decreased after the intervention, and the bilateral DLPFC was not activated during the intervention. A correlation was also found among all participants between the increase in WMC and the activation of the bilateral DLPFC. CONCLUSION:The study findings suggest that top-down attention control during FAM can activate the bilateral DLPFC and increase WMC among meditation novices.
10.1002/brb3.2288
Brain Plasticity and Neurophysiological Correlates of Meditation in Long-Term Meditators: A Fluorodeoxyglucose Positron Emission Tomography Study Based on an Innovative Methodology.
Magan Dipti,Yadav Raj Kumar,Bal Chandra Shekhar,Mathur Rashmi,Pandey Ravindra Mohan
Journal of alternative and complementary medicine (New York, N.Y.)
Previous studies evaluating neurophysiological correlates of long-term meditation are constrained by some methodological limitations. The objective of this study was to measure changes in the regional cerebral glucose metabolism during meditation using a novel methodological approach. The present study was a part of a larger, nonrandomized, single-center open-label study. The study was conducted at the Department of Physiology and Department of Nuclear Medicine and Positron Emission Tomography. A dedicated place was set up as a yoga room, away from the positron emission tomography (PET) scanning room in the Department of Nuclear Medicine and Positron Emission Tomography, where meditators performed meditation in a peaceful environment in a sitting posture with eyes closed. The electroencephalography (EEG) was recorded to affirm the meditation objectively. Twenty-four sets of PET scans were obtained at 2 different occasions (baseline and postmeditation within 40 min of FDG [fluorodeoxyglucose] injection) from 12 apparently healthy, male, right-handed long-term meditators practicing meditation (since >5 years, at least 5 days a week) who were recruited from a well-established meditation center in Delhi. Changes in the regional cerebral glucose metabolism during meditation versus baseline. Regional cluster analysis showed significantly activated well-defined areas of fronto-parieto-temporal regions of the right versus left hemisphere during meditation. Interestingly, right homolog of Broca's area and right lentiform nucleus were hyperactive during meditation in all the meditators. Long-term meditation might potentially enhance the explicit functions of specific parts of the right hemisphere, possibly due to neuroplastic changes in the brain. Importantly, results of the current study are encouraging and show a novel methodological approach to acquire FDG PET/CT (computed tomography) images. The study was registered at Clinical Trial Registry India (CTRI), CTRI/2009/091/000727.
10.1089/acm.2019.0167
A potential association of meditation with menopausal symptoms and blood chemistry in healthy women: A pilot cross-sectional study.
Sung Min-Kyu,Lee Ul Soon,Ha Na Hyun,Koh Eugene,Yang Hyun-Jeong
Medicine
Owing to hormonal changes, women experience various psychophysiological alterations over a wide age range, which may result in decreased quality of life as well as in increased risks of diseases, such as cardiovascular diseases. Although studies have been performed to research complementary methods, such as meditation, the research field still requires an adequate amount of studies for public health guidelines. This pilot cross-sectional study aims to investigate a potential association of meditation with menopausal symptoms and blood chemistry for healthy women. In this study, data of 65 healthy women (age range 25-67) including 33 meditation practitioners and 32 meditation-naïve controls were analyzed to compare the Menopausal Rating Scale scores and blood chemistry with 7 more dropouts in the blood chemistry. For blood chemistry, nine components including glucose (GLU) and high-density lipoprotein cholesterol (HDL) were measured. Two-way analysis of variance was performed by dividing the total participants into 2 groups: premenopausal and postmenopausal participants. Compared to the control group, the meditation group showed a trend of reductions in the Menopausal Rating Scale total score (P = .054) and its 2 subcomponents: depressive mood (P = .064) and irritability (P = .061). In HDL level, there was a significant interaction between group and menopausal state (P = .039) with following post hoc results: among the premenopausal participants, a significant increase in the meditation group compared to the control group (P = .005); among the control group, a significant increase in the postmenopausal compared to the premenopausal participants (P = .030). In GLU level, there was a mild interaction between group and menopausal state (P = .070) with following post hoc results: among the postmenopausal participants, a trend of increase in the control group compared to the meditation group (P = .081); among the control group, a significant increase in the postmenopausal compared to the premenopausal participants (P = .040). Our research suggests a potential association of practicing meditation with alleviations in menopausal symptoms and changes in blood chemistry, warranting further studies with a longitudinal study design and larger populations to understand the underlying causal relationships.
10.1097/MD.0000000000022048
Metta-based group meditation and individual cognitive behavioral therapy (MeCBT) for chronic depression: study protocol for a randomized controlled trial.
Trials
BACKGROUND:Depression is a widespread disorder with severe impacts for individuals and society, especially in its chronic form. Current treatment approaches for persistent depression have focused primarily on reducing negative affect and have paid little attention to promoting positive affect. Previous studies have shown that metta meditation increases positive affect in chronically depressed patients. Results from previous trials provide evidence for the efficacy of a stand-alone metta meditation group treatment in combination with mindfulness-based approaches. Further research is needed to better understand the implementation of meditation practice into everyday life. Therefore, mindfulness and metta meditation in a group setting are combined with individual cognitive behavioral therapy (CBT) into a new, low-intensity, cost-effective treatment ("MeCBT") for chronic depression. METHODS/DESIGN:In this single-center, randomized, observer-blinded, parallel-group clinical trial we will test the efficacy of MeCBT in reducing depression compared to a wait-list control condition. Forty-eight participants in a balanced design will be allocated randomly to a treatment group or a wait-list control group. Metta-based group meditation will be offered in eight weekly sessions and one additional half-day retreat. Subsequent individual CBT will be conducted in eight fortnightly sessions. Outcome measures will be assessed at four time points: before intervention (T0); after group meditation (T1); after individual CBT (T2); and, in the treated group only, at 6-month follow-up (T3). Changes in depressive symptoms (clinician rating), assessed with the Quick Inventory of Depressive Symptoms (QIDS-C) are the primary outcome. We expect a significant decline of depressive symptoms at T2 compared to the wait-list control group. Secondary outcome measures include self-rated depression, mindfulness, benevolence, rumination, emotion regulation, social connectedness, social functioning, as well as behavioral and cognitive avoidance. We will explore changes at T1 and T2 in all these secondary outcome variables. DISCUSSION:To our knowledge this is the first study to combine a group program focusing on Metta meditation with state-of-the art individual CBT specifically tailored to chronic depression. Implications for further refinement and examination of the treatment program are discussed. TRIAL REGISTRATION:ISRCTN, ISRCTN97264476. Registered 29 March 2018 (applied on 14 December 2017)-retrospectively registered.
10.1186/s13063-019-3815-4
Sahaj Samadhi Meditation versus a Health Enhancement Program for depression in chronic pain: protocol for a randomized controlled trial and implementation evaluation.
Sud Abhimanyu,Nelson Michelle L A,Cheng Darren K,Armas Alana,Foat Kirk,Greiver Michelle,Hosseiny Fardous,Katz Joel,Moineddin Rahim,Mulsant Benoit H,Newman Ronnie I,Rivlin Leon,Vasudev Akshya,Upshur Ross
Trials
BACKGROUND:Despite the high prevalence of comorbid chronic pain and depression, this comorbidity remains understudied. Meditation has demonstrated efficacy for both chronic pain and depression independently, yet there have been few studies examining its effectiveness when both conditions are present concurrently. Furthermore, while meditation is generally accepted as a safe and effective health intervention, little is known about how to implement meditation programs within or alongside the health care system. METHODS:We will conduct a hybrid type 1 effectiveness-implementation evaluation. To measure effectiveness, we will conduct a randomized controlled trial comparing Sahaj Samadhi Meditation and the Health Enhancement Program in 160 people living with chronic pain, clinically significant depressive symptoms, and on long-term opioid therapy. Changes in depressive symptoms will be our primary outcome; pain severity, pain-related function, opioid use, and quality of life will be the secondary outcomes. The primary end point will be at 12 weeks with a secondary end point at 24 weeks to measure the sustainability of acute effects. Patients will be recruited from a community-based chronic pain clinic in a large urban center in Mississauga, Canada. The meditation program will be delivered in the clinical environment where patients normally receive their chronic pain care by certified meditation teachers who are not regulated health care providers. We will use a mixed-methods design using the multi-level framework to understand the implementation of this particular co-location model. DISCUSSION:Results of this hybrid evaluation will add important knowledge about the effectiveness of meditation for managing depressive symptoms in people with chronic pain. The implementation evaluation will inform both effectiveness outcomes and future program development, scalability, and sustainability. TRIAL REGISTRATION:ClinicalTrials.gov: NCT04039568. Registered on 31 July 2019.
10.1186/s13063-020-04243-z
A Bibliometric and Visualization Analysis of Mindfulness and Meditation Research from 1900 to 2021.
International journal of environmental research and public health
This study comprehensively summarizes research in the field of meditation, especially mindfulness meditation from 1900 to 2021, by analyzing the knowledge map through CiteSpace and VOSviewer software. Using "mindfulness *" or "meditation *" as the topic, articles included in the Science Citation Index Expanded and Social Sciences Citation Index were searched in the web of science core database, resulting in the selection of 19,752 articles. Over half a century ago, Deikman published the field's first article in the Journal of Nervous and Mental Disease in 1963, and publications have soared in subsequent decades. The USA is in the core position in terms of global collaboration, total publication numbers, and total citations. The journal ranked first for the most published articles and citations. "The benefits of being present: Mindfulness and its role in psychological well-being," written by Brown and Ryan, was the most cited article. Mindfulness, meditation, depression, intervention, stress reduction, stress, and anxiety are the top co-occurrence keywords. The timeline of cluster analysis discloses that before 2010, hypertension, cancer, mindfulness, generalized anxiety disorder, and other topics received great attention. In the decade since 2010, scholars have shown interest in meta-analysis, attention, and self-assessment, and keen attention to mindfulness-based interventions. These findings provide an important foundation to direct future research.
10.3390/ijerph182413150
Mindfulness Meditation: Impact on Attentional Control and Emotion Dysregulation.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
OBJECTIVE:Theoretical models of mindfulness meditation conceptualize the cultivation of focused attention and regulation of emotional states, with the attitudinal foundations that promote nonjudgment and acceptance, to facilitate cognitive and affective processing resulting in improved brain health. Within the scientific study of mindfulness meditation, outcomes assessing behavioral and neural correlates of attentional control and emotion regulation have been examined for their malleability as a function of engagement in mindfulness practices. This review synthesizes the results of our pilot trials examining the preliminary effects of mindfulness meditation on metrics of cognitive, affective, and brain health in older adults and in individuals with multiple sclerosis. CONCLUSIONS:There is promising support for mindfulness meditation to enhance attentional control, reduce mind-wandering, and reduce emotion dysregulation. However, well-powered efficacy trials, with an objective assessment of mindfulness practice data are needed to further provide causal and comprehensive evidence supporting the efficacy of mindfulness meditation for brain health. Inclusion of independently derived and validated brain-based signatures of cognitive and affective functioning can additionally enable a parsimonious understanding of how mindfulness meditation can causally impact metrics of functional and structural integrity of the human brain.
10.1093/arclin/acab053
Three months-longitudinal changes in relative telomere length, blood chemistries, and self-report questionnaires in meditation practitioners compared to novice individuals during midlife.
Medicine
Aging accelerates during midlife. Researches have shown the health benefits of mind-body intervention (MBI). However, whether MBI is involved with aging process has not been well understood. In this study, we approach to examine the relations of MBI with this process by investigating an aging marker of the peripheral blood, blood chemistry, and self-report questionnaires. A quasi-experimental design was applied. Experienced MBI practitioners participated in a 3-month intensive meditation training, while the age, gender-matched MBI-naïve controls led a normal daily life. Measurements were taken at before and after the 3 months for relative telomere length (RTL), blood chemistry, and self-report questionnaires including items about sleep quality, somatic symptoms, depression, anxiety, stress, emotional intelligence (EI), and self-regulation. For RTL, the repeated measures analysis of variance showed a significant group*time interaction (P = .013) with a significant post hoc result (P = .030) within the control group: RTL was significantly reduced in the control while it was maintained in the meditation group. In repeated measures analysis of variance for blood chemistries, there were significant group differences between the groups in glucose and total protein. In the post hoc comparison analysis, at post measurements, the meditation group exhibited significantly lower values than the control group in both glucose and total protein. There were significant group-wise differences in the correlations of RTL with triglyceride (TG), high-density lipoprotein (HDL), glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Any of self-report results did not show significant changes in group*time interaction. However, there were group differences with significant (P < .05) or a tendency (.05 < P < .1) level. There were significant improvements in depression, stress and EI as well as tendencies of improvement in sleep quality and anxiety, in the meditation group compared to the control group. Our results suggest that meditation practice may have a potential to modify aging process in molecular cellular level combined with changes in psychological dimension.
10.1097/MD.0000000000030930
Meditation program mitigates loneliness and promotes wellbeing, life satisfaction and contentment among retired older adults: a two-year follow-up study in four South Asian cities.
Pandya Samta P
Aging & mental health
OBJECTIVES:To examine the impact of a meditation program in mitigating loneliness and promoting wellbeing, life satisfaction and contentment among retired South Asian older adults. METHOD:Intervention group older adults (IN=166) underwent weekly classes of the customized meditation program for 2 years as compared to the control group (CN=157) who underwent no intervention. Four scales were used to measure the outcomes: De Jong Gierveld Loneliness Scale (six-items), Warwick-Edinburgh Mental Wellbeing Scale, Satisfaction with Life Scale and Contentment with Life Assessment Scale. RESULTS:There were significant mean differences in the post-test scores on loneliness, wellbeing, life satisfaction and contentment outcomes of the intervention group, with high observed effect sizes (Cohen's range = 2.43-8.78, ≤.01). The intervention group older adults reported that they were less lonely and experienced greater wellbeing, life satisfaction and contentment post-test (η =.71-.78, ≤.01). Within the intervention cohort, post-test scores were higher for men, Hindus, middle class, married, living with spouse/children/kin, with acquired treatable lifestyle ailments, who attended 76-100 meditation lessons and regularly practiced at home. Results of the hierarchical regression models indicated that home practice was the strongest predictor explaining 17% (±.82%) variation in the outcomes. The structural equation models indicated that meditation lessons attended and home practice mediated the relationship between demographic variables and outcomes. CONCLUSION:The customized meditation program is an effective loneliness-mitigating intervention for retired older adults. Identifying social cognition as a function of loneliness, this intervention addresses negative thoughts and feelings associated with a mental perception of loneliness.
10.1080/13607863.2019.1691143
Attentional and cognitive monitoring brain networks in long-term meditators depend on meditation states and expertise.
Yordanova Juliana,Kolev Vasil,Nicolardi Valentina,Simione Luca,Mauro Federica,Garberi Patrizia,Raffone Antonino,Malinowski Peter
Scientific reports
Meditation practice is suggested to engage training of cognitive control systems in the brain. To evaluate the functional involvement of attentional and cognitive monitoring processes during meditation, the present study analysed the electroencephalographic synchronization of fronto-parietal (FP) and medial-frontal (MF) brain networks in highly experienced meditators during different meditation states (focused attention, open monitoring and loving kindness meditation). The aim was to assess whether and how the connectivity patterns of FP and MF networks are modulated by meditation style and expertise. Compared to novice meditators, (1) highly experienced meditators exhibited a strong theta synchronization of both FP and MF networks in left parietal regions in all mediation styles, and (2) only the connectivity of lateralized beta MF networks differentiated meditation styles. The connectivity of intra-hemispheric theta FP networks depended non-linearly on meditation expertise, with opposite expertise-dependent patterns found in the left and the right hemisphere. In contrast, inter-hemispheric FP connectivity in faster frequency bands (fast alpha and beta) increased linearly as a function of expertise. The results confirm that executive control systems play a major role in maintaining states of meditation. The distinctive lateralized involvement of FP and MF networks appears to represent a major functional mechanism that supports both generic and style-specific meditation states. The observed expertise-dependent effects suggest that functional plasticity within executive control networks may underpin the emergence of unique meditation states in expert meditators.
10.1038/s41598-021-84325-3
Estimation of Motion and Respiratory Characteristics during the Meditation Practice Based on Video Analysis.
Kashevnik Alexey,Othman Walaa,Ryabchikov Igor,Shilov Nikolay
Sensors (Basel, Switzerland)
Meditation practice is mental health training. It helps people to reduce stress and suppress negative thoughts. In this paper, we propose a camera-based meditation evaluation system, that helps meditators to improve their performance. We rely on two main criteria to measure the focus: the breathing characteristics (respiratory rate, breathing rhythmicity and stability), and the body movement. We introduce a contactless sensor to measure the respiratory rate based on a smartphone camera by detecting the chest keypoint at each frame, using an optical flow based algorithm to calculate the displacement between frames, filtering and de-noising the chest movement signal, and calculating the number of real peaks in this signal. We also present an approach to detecting the movement of different body parts (head, thorax, shoulders, elbows, wrists, stomach and knees). We have collected a non-annotated dataset for meditation practice videos consists of ninety videos and the annotated dataset consists of eight videos. The non-annotated dataset was categorized into beginner and professional meditators and was used for the development of the algorithm and for tuning the parameters. The annotated dataset was used for evaluation and showed that human activity during meditation practice could be correctly estimated by the presented approach and that the mean absolute error for the respiratory rate is around 1.75 BPM, which can be considered tolerable for the meditation application.
10.3390/s21113771
Heart Rate Variability, Cortisol and Attention Focus During Shamatha Quiescence Meditation.
Blase Kees L,van Waning Adeline
Applied psychophysiology and biofeedback
Cardiac vagal tone can be seen as a stable marker for the ability to sustain attention and regulate emotion, two factors associated with the quality of meditation. In this study, heart rate variability (HRV) has been monitored in different forms of Shamatha quiescence meditation: three breath meditations, Settling the Mind in its natural state, Awareness of Awareness, Loving-kindness and Tonglen. Establish and test a practical means of monitoring neurobiological effects of meditation. Over 6 weeks, two experimental groups practiced Shamatha meditation on a daily basis (n = 20). HRV patterns and cortisol tests were monitored at three measuring points during these weeks, and an attention focus test was performed at the start and after 6 weeks. Six weeks of regular practice in Shamatha meditation were associated with HRV indices suggesting improvements in the homeostatic regulation of the autonomic nervous system (ANS) in 85% of the HRV recordings (tachogram and frequency specter) of all 20 subjects. Further, a substantial decrease in cortisol levels was also noted. The attention focus test showed a significant increase of 18.7% in sustained attention, moving from medium to high attention focus, with a significant result of t(20) = - 8.764 and p < 0.001. Participants reported positive subjective changes in attention focus, sense of happiness and calmness and increased abilities in emotional regulation and attunement. Six weeks of regular practice in Shamatha meditation contributes to a substantial increase of attention focus and a decrease in stress levels evidenced in changes in diurnal cortisol measures. HRV biofeedback shows that the sympathetic nervous system is counterbalanced by increased vagal tone, and autonomic balance is enhanced by all Shamatha meditations, not only breath meditations, but also mind meditations: Settling the Mind in its natural state, Awareness of Awareness, Loving-kindness and Tonglen. Although these results are promising, further research is recommended with HRV biofeedback instruments to report statistical analysis and to understand unique HRV patterns in Shamatha mind meditation.
10.1007/s10484-019-09448-w
Meditation-induced cognitive-control states regulate working memory task performance.
Ma Ke,Deng Na,Hommel Bernhard
Quarterly journal of experimental psychology (2006)
Single-bout focused-attention meditation (FAM) and open-monitoring meditation (OMM) are assumed to bias metacontrol states towards more persistent versus more flexible processing, respectively. In Experiment 1, we tested whether monitoring and updating of working memory (WM) representations in an -back task with high (3-back), medium (2-back), and low (1-back) WM demands (varied within participants) is affected by preceding single-bout FAM or OMM meditation (varied between participants and compared with a control group). The results showed that FAM promotes WM performance in the medium (2-back), but not in the high (3-back) or low (1-back) demand condition, whereas OMM did not affect WM performance. A replication of the 2-back condition only (Experiment 2) showed no meditation effect, but a replication of the 3-back condition only (Experiment 3) produced a similar pattern as the 2-back condition in Experiment 1, with FAM promoting performance compared with OMM and the control condition. Taken together, these findings suggest that the single-bout FAM does promote WM performance but only if the capacity demands are neither too high nor too low.
10.1177/1747021821997826
Feasibility, Acceptability, and Preliminary Efficacy of an App-Based Mindfulness-Meditation Program Among Older Adults.
Mahlo Leeann,Windsor Tim D
The Gerontologist
BACKGROUND AND OBJECTIVES:Few studies have focused on the utility of mindfulness-meditation for well-being in older adults. The present study investigated the feasibility, acceptability, and preliminary efficacy of an app-based mindfulness-meditation program among older adults. RESEARCH DESIGN AND METHODS:A community-based sample of 46 participants aged between 63 and 81 (M = 70.85, SD = 4.70) engaged with a 30-day app-based mindfulness-meditation program for 10 min daily on their smartphones. Each meditation session comprised focusing on the breath, mentally scanning the body, monitoring the mind's activity, and cultivating a nonjudgmental orientation toward experiences. Participants completed questionnaires at baseline, day 10, and day 30. RESULTS:On average, participants completed 25 sessions and almost 4 h of application use across the 30 days. Results of linear mixed effects models showed significant improvements in positive affect, negative affect, and life satisfaction across the study interval, but no meaningful change in total mindfulness or perceived stress. Furthermore, relative to high levels of smartphone efficacy, low smartphone efficacy was associated with higher perceived stress and negative affect, and less life satisfaction at baseline; and steeper improvements on these outcomes across the study interval. On average, older adults rated the app-based mindfulness-meditation training as interesting, enjoyable, valuable, and useful. DISCUSSION AND IMPLICATIONS:The findings provide preliminary support for the feasibility and acceptability of an app-based mindfulness-meditation program with community-dwelling older adults and demonstrate potential benefits for well-being. Results suggest the value of further research investigating the efficacy of digital mindfulness-meditation interventions for older adults via larger randomized controlled trials.
10.1093/geront/gnaa093
From many to (n)one: Meditation and the plasticity of the predictive mind.
Laukkonen Ruben E,Slagter Heleen A
Neuroscience and biobehavioral reviews
How profoundly can humans change their own minds? In this paper we offer a unifying account of deconstructive meditation under the predictive processing view. We start from simple axioms. First, the brain makes predictions based on past experience, both phylogenetic and ontogenetic. Second, deconstructive meditation brings one closer to the here and now by disengaging anticipatory processes. We propose that practicing meditation therefore gradually reduces counterfactual temporally deep cognition, until all conceptual processing falls away, unveiling a state of pure awareness. Our account also places three main styles of meditation (focused attention, open monitoring, and non-dual) on a single continuum, where each technique relinquishes increasingly engrained habits of prediction, including the predicted self. This deconstruction can also permit certain insights by making the above processes available to introspection. Our framework is consistent with the state of empirical and (neuro)phenomenological evidence and illuminates the top-down plasticity of the predictive mind. Experimental rigor, neurophenomenology, and no-report paradigms are needed to further understanding of how meditation affects predictive processing and the self.
10.1016/j.neubiorev.2021.06.021
Changes in the Electrical Activity of the Brain in the Alpha and Theta Bands during Prayer and Meditation.
Dobrakowski Paweł,Blaszkiewicz Michal,Skalski Sebastian
International journal of environmental research and public health
Focused attention meditation (FAM) is a category of meditation based on an EEG pattern, which helps the wandering mind to focus on a particular object. It seems that prayer may, in certain respects, be similar to FAM. It is believed that emotional experience correlates mainly with theta, but also with selective alpha, with internalized attention correlating mainly with the synchronous activity of theta and alpha. The vast majority of studies indicate a possible impact of transcendence in meditation on the alpha wave in EEG. No such reports are available for prayer. Seventeen women and nineteen men aged 27-64 years with at least five years of intensive meditation/prayer experience were recruited to participate in the study. We identified the two largest groups which remained in the meditation trend originating from the Buddhist system (14 people) (Buddhist meditators) and in the Christian-based faith (15 people) (Christian meditators). EEG signal was recorded with open eyes, closed eyes, during meditation/prayer, and relaxation. After the EEG recording, an examination was conducted using the Scale of Spiritual Transcendence. Buddhist meditators exhibited a statistically significantly higher theta amplitude at Cz during meditation compared to relaxation. Meanwhile, spiritual openness favored a higher theta amplitude at Pz during relaxation. Our study did not reveal statistically significant differences in frontal areas with regard to alpha and theta, which was often indicated in previous studies. It seems necessary to analyze more closely the midline activity in terms of dispersed neural activity integration.
10.3390/ijerph17249567
Differential effects of mindfulness meditation conditions on repetitive negative thinking and subjective time perspective: a randomized active-controlled study.
Feruglio Susanna,Matiz Alessio,Grecucci Alessandro,Pascut Stefania,Fabbro Franco,Crescentini Cristiano
Psychology & health
Preliminary findings suggest that different kinds of meditation could work on diverse cognitive and psychological processes. The present study aimed at disentangling the effects of three mindfulness techniques on mental rumination and subjective time perspective. 75 young healthy participants were randomly assigned to one of four conditions: mindful breathing, body scan, observing-thoughts meditation and an active control condition. The meditation groups practiced mindfulness daily and attended weekly group meetings for 8 weeks, while the control group was involved in reading and discussing a book about mindfulness. Self-report measures of mindfulness skills, ruminative thinking, attitude towards time, anxiety, depression and personality traits. In all meditation conditions, analysis of covariance showed a significant improvement in mindfulness skills compared to the control group. We found a specific effect of mindful breathing in reducing participants' tendency to brooding and in increasing their positive vision of the future, compared to all other conditions. As expected, we found some differential effects: breathing meditation helped practitioners to train more effectively their ability to disengage from maladaptive ruminative thoughts, which could be reflected in a more optimistic attitude toward the future. These results provide useful information to structure better mindfulness-based interventions.
10.1080/08870446.2020.1836178
Meditation: Evidence Map of Systematic Reviews.
Frontiers in public health
This evidence map presents a summary of studies that addressed the effects of meditation on various clinical and health conditions. Meditation is a contemplative practice that has been used for the promotion of health, and the treatment of different conditions. The study is based on the search of four electronic databases for the period 1994-November 2019 and includes systematic reviews, meta-analyses, meta-syntheses, and integrative reviews. 3iE evidence gap map was the methodology of choice, and AMSTAR 2 was used for the analyses. Tableau was used to graphically display the confidence level, number of reviews, health outcomes, and intervention effects. This map encompasses 191 studies, with Mindfulness being the key word that retrieved the highest number of results. Several meditation techniques were evaluated in different contexts, and the confidence levels of 22 studies were high, 84 were moderate, and 82 were low. Two 2 meta-syntheses and 1 integrative review were also included. Most of the studies reported positive effects and a beneficial potential of the practice of meditation. Health outcomes were divided into five groups out of which mental health and vitality, and well-being and quality of life stood out with the largest number of studies. Meditation has been applied in different areas. This Evidence Map intends to be an easy visual tool to access valuable evidence-based information on this complementary therapy for patients, health professionals, and managers.
10.3389/fpubh.2021.742715
A mindfulness meditation mobile app improves depression and anxiety in adults with sleep disturbance: Analysis from a randomized controlled trial.
Huberty Jennifer,Puzia Megan E,Green Jeni,Vlisides-Henry Robert D,Larkey Linda,Irwin Michael R,Vranceanu Ana-Maria
General hospital psychiatry
OBJECTIVE:The objective of this study was to 1) determine the effects of a meditation app on depression and anxiety in adults with sleep disturbance, and 2) explore the potential mediating effects of fatigue, daytime sleepiness, and pre-sleep arousal on the relationship between use of the meditation app and changes in depression and anxiety. METHODS:Participants were 239 adults with elevated insomnia symptoms (i.e., scores ≥ 10 on the Insomnia Severity Index) and limited or no previous experience with meditation. Depression, anxiety, fatigue, daytime sleepiness, and pre-sleep arousal were assessed at baseline, four weeks, and eight weeks. Repeated-measures ANCOVAs assessed intervention effects on depression and anxiety. Mediation models were estimated using the PROCESS macro. RESULTS:Participants in the meditation group had more improvement in depression and anxiety symptoms during the intervention period than did those in the control group. Changes in somatic and cognitive pre-sleep arousal at mid-intervention fully mediated effects on depression and partially mediated effects on anxiety. There were no significant indirect effects of fatigue and daytime-sleepiness on changes in mental health. CONCLUSIONS:A meditation app may improve depression and anxiety in adults with sleep disturbance, with effects being driven by improvements in pre-sleep arousal. Future studies should consider targeting pre-sleep arousal to improve mental health in this population.
10.1016/j.genhosppsych.2021.09.004
EEG alpha-theta dynamics during mind wandering in the context of breath focus meditation: An experience sampling approach with novice meditation practitioners.
Rodriguez-Larios Julio,Alaerts Kaat
The European journal of neuroscience
Meditation practice entails moments of distraction dominated by self-generated thoughts (i.e. mind wandering). Initial studies assessing the neural correlates of mind wandering in the context of meditation practice have identified an important role of theta (4-8 Hz) and alpha (8-14 Hz) neural oscillations. In this study, we use a probe-caught experience sampling paradigm to assess spectral changes in the theta-alpha frequency range during mind wandering in the context of breath focus meditation. Electroencephalography (EEG) was measured in 25 novice meditation practitioners during a breath focus task in which they were repeatedly probed to report whether they were focusing on their breath or thinking about something else. Mind wandering episodes were associated with an increase in the amplitude and a decrease in the frequency of theta (4-8 Hz) oscillations. Conversely, alpha oscillations (8-14 Hz) were shown to decrease in amplitude and increase in frequency during mind wandering relative to breath focus. In addition, mind wandering episodes were shown to be accompanied by increased harmonicity and phase synchrony between alpha and theta rhythms. Because similar spectral changes in the theta-alpha frequency range have been reported during controlled cognitive processes involving memory and executive control, we speculate that mind wandering and controlled processes could share some neurocognitive mechanisms. From a translational perspective, this study indicates that oscillatory activity in the theta-alpha frequency range could form adequate parameters for developing EEG-neurofeedback protocols aimed at facilitating the detection of mind wandering during meditation practice.
10.1111/ejn.15073
Reconfiguration of Electroencephalography Microstate Networks after Breath-Focused, Digital Meditation Training.
Brain connectivity
Sustained attention and working memory were improved in young adults after they engaged in a recently developed, closed-loop, digital meditation practice. Whether this type of meditation also has a sustained effect on dominant resting-state networks is currently unknown. In this study, we examined the resting brain states before and after a period of breath-focused, digital meditation training versus placebo using an electroencephalography (EEG) microstate approach. We found topographical changes in postmeditation rest, compared with baseline rest, selectively for participants who were actively involved in the meditation training and not in participants who engaged with an active, expectancy-match, placebo control paradigm. Our results suggest a reorganization of brain network connectivity after 6 weeks of intensive meditation training in brain areas, mainly including the right insula, the superior temporal gyrus, the superior parietal lobule, and the superior frontal gyrus bilaterally. These findings provide an opening for the development of a novel noninvasive treatment of neuropathological states by low-cost, breath-focused, digital meditation practice, which can be monitored by the EEG microstate approach.
10.1089/brain.2020.0848
Systematic Review for the Medical Applications of Meditation in Randomized Controlled Trials.
Kim Do-Young,Hong Soo-Hwa,Jang Seung-Hyeon,Park So-Hyeon,Noh Jung-Hee,Seok Jung-Mi,Jo Hyun-Jeong,Son Chang-Gue,Lee Eun-Jung
International journal of environmental research and public health
BACKGROUND:Meditation has been increasingly adapted for healthy populations and participants with diseases. Its beneficial effects are still challenging to determine due to the heterogeneity and methodological obstacles regarding medical applications. This study aimed to integrate the features of therapeutic meditation in randomized controlled trials (RCTs). METHODS:We conducted a systematic review of RCTs with meditation for populations with diseases using the PubMed database through June 2021. We analyzed the characteristics of the diseases/disorders, participants, measurements, and their overall benefits. RESULTS:Among a total of 4855 references, 104 RCTs were determined and mainly applied mindfulness-based (51 RCTs), yoga-based (32 RCTs), and transcendental meditation (14 RCTs) to 10,139 patient-participants. These RCTs were conducted for participants with a total of 45 kinds of disorders; the most frequent being cancer, followed by musculoskeletal and connective tissue diseases and affective mood disorder. Seven symptoms or signs were frequently assessed: depressive mood, feeling anxious, quality of life, stress, sleep, pain, and fatigue. The RCTs showed a higher ratio of positive outcomes for sleep (73.9%) and fatigue (68.4%). CONCLUSIONS:This systematic review produced the comprehensive features of RCTs for therapeutic meditation. These results will help physicians and researchers further study clinical adaptations in the future as reference data.
10.3390/ijerph19031244
Meditation affects word recognition of meditation novices.
Lusnig Larissa,Radach Ralph,Hofmann Markus J
Psychological research
This work represents one of the first attempts to examine the effects of meditation on the processing of written single words. In the present longitudinal study, participants conducted a lexical decision task and rated the affective valence of nouns before and after a 7-week class in mindfulness meditation, loving-kindness meditation, or a control intervention. Both meditation groups rated the emotional valence of nouns more neutral after the interventions, suggesting a general down-regulation of emotions. In the loving-kindness group, positive words were rated more positively after the intervention, suggesting a specific intensification of positive feelings. After both meditation interventions, response times in the lexical decision task accelerated significantly, with the largest facilitation occurring in the loving-kindness group. We assume that meditation might have led to increased attention, better visual discrimination, a broadened attentional focus, and reduced mind-wandering, which in turn enabled accelerated word recognition. These results extend findings from a previous study with expert Zen meditators, in which we found that one session of advanced meditation can affect word recognition in a very similar way.
10.1007/s00426-021-01522-5
Meditation-induced effects on whole-brain structural and effective connectivity.
Brain structure & function
In the past decades, there has been a growing scientific interest in characterizing neural correlates of meditation training. Nonetheless, the mechanisms underlying meditation remain elusive. In the present work, we investigated meditation-related changes in functional dynamics and structural connectivity (SC). For this purpose, we scanned experienced meditators and control (naive) subjects using magnetic resonance imaging (MRI) to acquire structural and functional data during two conditions, resting-state and meditation (focused attention on breathing). In this way, we aimed to characterize and distinguish both short-term and long-term modifications in the brain's structure and function. First, to analyze the fMRI data, we calculated whole-brain effective connectivity (EC) estimates, relying on a dynamical network model to replicate BOLD signals' spatio-temporal structure, akin to functional connectivity (FC) with lagged correlations. We compared the estimated EC, FC, and SC links as features to train classifiers to predict behavioral conditions and group identity. Then, we performed a network-based analysis of anatomical connectivity. We demonstrated through a machine-learning approach that EC features were more informative than FC and SC solely. We showed that the most informative EC links that discriminated between meditators and controls involved several large-scale networks mainly within the left hemisphere. Moreover, we found that differences in the functional domain were reflected to a smaller extent in changes at the anatomical level as well. The network-based analysis of anatomical pathways revealed strengthened connectivity for meditators compared to controls between four areas in the left hemisphere belonging to the somatomotor, dorsal attention, subcortical and visual networks. Overall, the results of our whole-brain model-based approach revealed a mechanism underlying meditation by providing causal relationships at the structure-function level.
10.1007/s00429-022-02496-9
Impact of Virtual Heartfulness Meditation Program on Stress, Quality of Sleep, and Psychological Wellbeing during the COVID-19 Pandemic: A Mixed-Method Study.
Desai Kunal,Gupta Pratibha,Parikh Priti,Desai Alpa
International journal of environmental research and public health
Stress and lack of quality sleep affect a large portion of the population around the globe, and the COVID-19 pandemic has genuinely brought attention to these problems. This study aimed to investigate whether using a virtual heart-based meditation program is associated with improved stress levels and quality of sleep among participants from the general population during the COVID-19 pandemic. We recruited 63 participants to receive an 8-week virtually conducted Heartfulness meditation program in a prospective pre-post single-arm intervention study from September 28 to November 22 2020. Perceived Stress Scale (PSS) and Pittsburgh Sleep Quality Index (PSQI) scores were collected at baseline, at 4 weeks, and 8 weeks. Of the 63 participants enrolled in the study, 36 (57%) completed an 8-week Heartfulness meditation program. There was a significant decrease in PSS (mean difference of 6.68 with 95% C.I. 4.89-8.47, < 0.0001) and in PSQI (mean difference of 2.05 with 95% C.I. 1.03-3.07, < 0.0001) between week zero and week eight, regardless of Health Care Professional status. The qualitative thematic analysis strongly supported the survey results. A significant reduction in perceived stress score and improvement in sleep quality index was noted at the end of a virtual Heartfulness meditation program. Moreover, Heartfulness meditation practice may help cultivate the quality of empathy, acceptance, and individual peace. We conclude that the effects of virtually accessible Heartfulness meditation practice need to be explored further in larger studies.
10.3390/ijerph182111114
Meditation-based intervention for obsessive-compulsive disorder: A PRISMA-compliant systematic review and meta-analysis.
Medicine
BACKGROUND:The purpose of this study was to investigate the effects of the meditation-based intervention on obsessive-compulsive disorder (OCD). METHODS:The following databases were searched up to April 2021: the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, Medline (via PubMed), PsycARTICLES, 4 Korean databases (Korean Medical Database [KMbase], Koreanstudies Information Service System [KISS], National Digital Science Library [NDSL], and Oriental Medicine Advanced Searching Integrated System [OASIS]), and China National Knowledge Infrastructure (CNKI). The search terms related to meditation-based intervention and OCD were used. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The selected articles were evaluated using the Cochrane risk of bias tool. The Review Manager (RevMan) 5.4 was used to perform the meta-analysis. RESULTS:In all, 16 randomized controlled trials were selected. The meta-analysis showed that the group receiving the treatment combining medication and meditation-based intervention for OCD showed a more significant post-treatment improvement in Yale-Brown obsessive compulsive scale than the group receiving medication only. Compared with other non-medication interventions that are known to be effective in treating OCD, the Yale-Brown obsessive compulsive scale showed a significant improvement immediately after the meditation-based intervention. However, no significant difference was found in the follow-up monitoring data across all examined cases. CONCLUSION:This study was conducted to verify the effects of meditation-based intervention on OCD. The results suggested that combined treatment with medication and meditation-based intervention was more effective in treating OCD than medication alone; the positive effects of meditation-based intervention may be greater than the effects of other non-medication interventions. However, the lack of significant difference in the follow-up indicates that long-term effect of meditation-based interventions is unclear. TRIAL REGISTRATION NUMBER:PROSPERO CRD42021244408.
10.1097/MD.0000000000029147
Mining the Mind: Linear Discriminant Analysis of MEG Source Reconstruction Time Series Supports Dynamic Changes in Deep Brain Regions During Meditation Sessions.
Calvetti Daniela,Johnson Brian,Pascarella Annalisa,Pitolli Francesca,Somersalo Erkki,Vantaggi Barbara
Brain topography
Meditation practices have been claimed to have a positive effect on the regulation of mood and emotions for quite some time by practitioners, and in recent times there has been a sustained effort to provide a more precise description of the influence of meditation on the human brain. Longitudinal studies have reported morphological changes in cortical thickness and volume in selected brain regions due to meditation practice, which is interpreted as an evidence its effectiveness beyond the subjective self reporting. Using magnetoencephalography (MEG) or electroencephalography to quantify the changes in brain activity during meditation practice represents a challenge, as no clear hypothesis about the spatial or temporal pattern of such changes is available to date. In this article we consider MEG data collected during meditation sessions of experienced Buddhist monks practicing focused attention (Samatha) and open monitoring (Vipassana) meditation, contrasted by resting state with eyes closed. The MEG data are first mapped to time series of brain activity averaged over brain regions corresponding to a standard Destrieux brain atlas. Next, by bootstrapping and spectral analysis, the data are mapped to matrices representing random samples of power spectral densities in [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] frequency bands. We use linear discriminant analysis to demonstrate that the samples corresponding to different meditative or resting states contain enough fingerprints of the brain state to allow a separation between different states, and we identify the brain regions that appear to contribute to the separation. Our findings suggest that the cingulate cortex, insular cortex and some of the internal structures, most notably the accumbens, the caudate and the putamen nuclei, the thalamus and the amygdalae stand out as separating regions, which seems to correlate well with earlier findings based on longitudinal studies.
10.1007/s10548-021-00874-w
Identifying App-Based Meditation Habits and the Associated Mental Health Benefits: Longitudinal Observational Study.
Stecher Chad,Berardi Vincent,Fowers Rylan,Christ Jaclyn,Chung Yunro,Huberty Jennifer
Journal of medical Internet research
BACKGROUND:Behavioral habits are often initiated by contextual cues that occur at approximately the same time each day; so, it may be possible to identify a reflexive habit based on the temporal similarity of repeated daily behavior. Mobile health tools provide the detailed, longitudinal data necessary for constructing such an indicator of reflexive habits, which can improve our understanding of habit formation and help design more effective mobile health interventions for promoting healthier habits. OBJECTIVE:This study aims to use behavioral data from a commercial mindfulness meditation mobile phone app to construct an indicator of reflexive meditation habits based on temporal similarity and estimate the association between temporal similarity and meditation app users' perceived health benefits. METHODS:App-use data from June 2019 to June 2020 were analyzed for 2771 paying subscribers of a meditation mobile phone app, of whom 86.06% (2359/2771) were female, 72.61% (2012/2771) were college educated, 86.29% (2391/2771) were White, and 60.71% (1664/2771) were employed full-time. Participants volunteered to complete a survey assessing their perceived changes in physical and mental health from using the app. Receiver operating characteristic curve analysis was used to evaluate the ability of the temporal similarity measure to predict future behavior, and variable importance statistics from random forest models were used to corroborate these findings. Logistic regression was used to estimate the association between temporal similarity and self-reported physical and mental health benefits. RESULTS:The temporal similarity of users' daily app use before completing the survey, as measured by the dynamic time warping (DTW) distance between app use on consecutive days, significantly predicted app use at 28 days and at 6 months after the survey, even after controlling for users' demographic and socioeconomic characteristics, total app sessions, duration of app use, and number of days with any app use. In addition, the temporal similarity measure significantly increased in the area under the receiver operating characteristic curve (AUC) for models predicting any future app use in 28 days (AUC=0.868 with DTW and 0.850 without DTW; P<.001) and for models predicting any app use in 6 months (AUC=0.821 with DTW and 0.802 without DTW; P<.001). Finally, a 1% increase in the temporal similarity of users' daily meditation practice with the app over 6 weeks before the survey was associated with increased odds of reporting mental health improvements, with an odds ratio of 2.94 (95% CI 1.832-6.369). CONCLUSIONS:The temporal similarity of the meditation app use was a significant predictor of future behavior, which suggests that this measure can identify reflexive meditation habits. In addition, temporal similarity was associated with greater perceived mental health benefits, which demonstrates that additional mental health benefits may be derived from forming reflexive meditation habits.
10.2196/27282
Using Personalized Anchors to Establish Routine Meditation Practice With a Mobile App: Randomized Controlled Trial.
Stecher Chad,Sullivan Mariah,Huberty Jennifer
JMIR mHealth and uHealth
BACKGROUND:Physical and mental health benefits can be attained from persistent, long-term performance of mindfulness meditation with a mobile meditation app, but in general, few mobile health app users persistently engage at a level necessary to attain the corresponding health benefits. Anchoring or pairing meditation with a mobile app to an existing daily routine can establish an unconsciously initiated meditation routine that may improve meditation persistence. OBJECTIVE:The purpose of this study was to test the use of either personalized anchors or fixed anchors for establishing a persistent meditation app routine with the mobile app, Calm. METHODS:We conducted a randomized controlled trial and randomly assigned participants to one of 3 study groups: (1) a personalized anchor (PA) group, (2) fixed anchor (FA) group, or (3) control group that did not use the anchoring strategy. All participants received app-delivered reminder messages to meditate for at least 10 minutes a day using the Calm app for an 8-week intervention period, and app usage data continued to be collected for an additional 8-week follow-up period to measure meditation persistence. Baseline, week 8, and week 16 surveys were administered to assess demographics, socioeconomic status, and changes in self-reported habit strength. RESULTS:A total of 101 participants across the 3 study groups were included in the final analysis: (1) PA (n=56), (2) FA (n=49), and (3) control group (n=62). Participants were predominantly White (83/101, 82.2%), female (77/101, 76.2%), and college educated (ie, bachelor's or graduate degree; 82/101, 81.2%). The FA group had a significantly higher average odds of daily meditation during the intervention (1.14 odds ratio [OR]; 95% CI 1.02-1.33; P=.04), and all participants experienced a linear decline in their odds of daily meditation during the 8-week intervention (0.96 OR; 95% CI 0.95-0.96; P<.001). Importantly, the FA group showed a significantly smaller decline in the linear trend of their odds of daily meditation during the 8-week follow-up (their daily trend increased by 1.04 OR from their trend during the intervention; 95% CI 1.01-1.06; P=.03). Additionally, those who more frequently adhered to their anchoring strategy during the intervention typically used anchors that occurred in the morning and showed a significantly smaller decline in their odds of daily meditation during the 8-week follow-up period (1.13 OR; 95% CI 1.02-1.35; P=.007). CONCLUSIONS:The FA group had more persistent meditation with the app, but participants in the FA or PA groups who more frequently adhered to their anchoring strategy during the intervention had the most persistent meditation routines, and almost all of these high anchorers used morning anchors. These findings suggest that the anchoring strategy can create persistent meditation routines with a mobile app. However, future studies should combine anchoring with additional intervention tools (eg, incentives) to help more participants successfully establish an anchored meditation routine. TRIAL REGISTRATION:ClinicalTrials.gov NCT04378530; https://clinicaltrials.gov/ct2/show/NCT04378530.
10.2196/32794
Attachment insecurity moderates emotion responses to mindfulness and loving-kindness meditation in adults raised in low socioeconomic status households.
Emotion (Washington, D.C.)
Research on attachment theory holds that insecure attachment influences people's daily social and emotional experiences. Mindfulness meditation and loving-kindness meditation have been associated with improvements in physical and mental well-being often through their influence on emotion experience and regulation. Yet, little research has examined how emotional well-being may be improved in insecurely attached individuals through meditation practice. We suspected that the emotion profiles of anxious and avoidant attachment may shift with meditation training, both across time and on a particular day. Improving emotional well-being may be especially consequential for those most at risk for negative health outcomes in late life. A diverse community sample of midlife adults raised in low-SES homes ( = 113; 55% white, 87.5% female) completed daily emotion reports for 10 weeks, during which they received 6 weeks of meditation training, randomized to either loving-kindness or mindfulness meditation practice. Results from growth curve analyses revealed that individuals with greater attachment anxiety and randomized to mindfulness meditation reported significant increases over time in positive emotions alongside decreases in negative emotions. Those high in attachment avoidance reported significant decreases in negative emotions in both meditation groups. On the daily level, within-person dose-response analyses revealed that individuals with greater attachment anxiety showed the most consistent dose-response relations between the duration of either meditation practice and same-day increases in positive emotions and decreases in negative emotions. These findings highlight how meditation interventions can shift emotion profiles of insecurely attached midlife adults who are at heightened risk for late life chronic illnesses. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
10.1037/emo0001049
Long-term Meditation Training Is Associated with Enhanced Subjective Attention and Stronger Posterior Cingulate-Rostrolateral Prefrontal Cortex Resting Connectivity.
Journal of cognitive neuroscience
Mindfulness meditation has been shown to increase resting-state functional connectivity (rsFC) between the posterior cingulate cortex (PCC) and dorsolateral prefrontal cortex (DLPFC), which is thought to reflect improvements in shifting attention to the present moment. However, prior research in long-term meditation practitioners lacked quantitative measures of attention that would provide a more direct behavioral correlate and interpretational anchor for PCC-DLPFC connectivity and was inherently limited by small sample sizes. Moreover, whether mindfulness meditation primarily impacts brain function locally, or impacts the dynamics of large-scale brain networks, remained unclear. Here, we sought to replicate and extend prior findings of increased PCC-DLPFC rsFC in a sample of 40 long-term meditators (average practice = 3759 hr) who also completed a behavioral assay of attention. In addition, we tested a network-based framework of changes in interregional connectivity by examining network-level connectivity. We found that meditators had stronger PCC-rostrolateral prefrontal cortex (RLPFC) rsFC, lower connector hub strength across the default mode network, and better subjective attention, compared with 124 meditation-naive controls. Orienting attention positively correlated with PCC-RLPFC connectivity and negatively correlated with default mode network connector hub strength. These findings provide novel evidence that PCC-RLPFC rsFC may support attention orienting, consistent with a role for RLPFC in the attention shifting component of metacognitive awareness that is a core component of mindfulness meditation training. Our results further demonstrate that long-term mindfulness meditation may improve attention and strengthen the underlying brain networks.
10.1162/jocn_a_01881
The EEG spectral properties of meditation and mind wandering differ between experienced meditators and novices.
Rodriguez-Larios Julio,Bracho Montes de Oca Eduardo A,Alaerts Kaat
NeuroImage
Previous literature suggests that individuals with meditation training become less distracted during meditation practice. In this study, we assess whether putative differences in the subjective experience of meditation between meditators and non-meditators are reflected in EEG spectral modulations. For this purpose, we recorded electroencephalography (EEG) during rest and two breath focus meditations (with and without experience sampling) in a group of 29 adult participants with more than 3 years of meditation experience and a control group of 29 participants without any meditation experience. Experience sampling in one of the meditation conditions allowed us to disentangle periods of breath focus from mind wandering (i.e. moments of distraction driven by task-irrelevant thoughts) during meditation practice. Overall, meditators reported a greater level of focus and reduced mind wandering during meditation practice than controls. In line with these reports, EEG spectral modulations associated with meditation and mind wandering also differed significantly between meditators and controls. While meditators (but not controls) showed a significant decrease in individual alpha frequency / amplitude and a steeper 1/f slope during meditation relative to rest, controls (but not meditators) showed a relative increase in individual alpha amplitude during mind wandering relative to breath focus periods. Together, our results show that the subjective experience of meditation and mind wandering differs between meditators and novices and that this is reflected in oscillatory and non-oscillatory properties of EEG.
10.1016/j.neuroimage.2021.118669
Mindfulness, happiness, and anxiety in a sample of college students before and after taking a meditation course.
Journal of American college health : J of ACH
OBJECTIVE:To explore differences in mindfulness, happiness, and perceived anxiety in a sample of college students before and after taking a meditation course. PARTICIPANTS:Participants were college students at a primarily undergraduate institution enrolled in an experiential meditation class ( = 74) and a non-meditation class comparison group ( = 73). METHODS:The study design was a before-after observational study with two groups and three dependent variables: the Mindfulness Attention Awareness Scale, the State Trait Anxiety Inventory and the Subjective Happiness Scale. RESULTS:Students in the meditation course increased average subjective happiness and mindfulness attention awareness. Mindfulness scores increased and anxiety decreased more for students in the meditation class compared to students in the psychosocial class. CONCLUSIONS:This research provides evidence that taking a semester long meditation course is associated with improvements in college student well-being.
10.1080/07448481.2020.1754839
The Effect of Juingong Meditation on the Theta to Alpha Ratio in the Temporoparietal and Anterior Frontal EEG Recordings.
Kim Joohyun,Kim Miji,Jang Miran,Lee Junyeop
International journal of environmental research and public health
(1) Background: The effect of Juingong meditation on brainwave patterns has not been explored yet. This study aimed to study the changes in brainwave patterns produced by Juingong meditation, through electroencephalography (EEG) measurements. (2) Methods: The study included 23 participants from the Hanmaum Seon Center in Korea. EEG measurements were performed using InteraXon's four-channel EEG measurement equipment, Muse. It measures EEG patterns in the temporoparietal and anterior frontal lobes. Brainwaves were measured in two different states: when Juingong meditation was practiced and when instructed mind wandering (IMW) was practiced. The EEG recordings were analyzed using the theta/alpha index. (3) Results: In the Juingong meditation state, the power of alpha was relatively higher than that of theta and these results were valid in the temporal parietal lobe channel. This indicates that relatively more alpha waves were induced in the temporal parietal lobe when Juingong meditation was practiced. (4) Conclusions: When Juingong meditation is practiced, the theta/alpha ratio changes without delay, which means that the practical effect of Juingong meditation on brainwave patterns is immediately apparent.
10.3390/ijerph19031721
No effect of focused attention and open monitoring meditation on EEG auditory mismatch negativity in expert and novice practitioners.
International journal of psychophysiology : official journal of the International Organization of Psychophysiology
The auditory mismatch negativity (MMN) is a well characterized event-related potential component which has gained recent attention in theoretical models describing the impact of various styles of mindfulness meditation on attentional processes and perceptual inference. Previous findings highlighted a distinct modulation of the MMN amplitude by different meditation practices and degrees of expertise. In the present study, we attempted to replicate results from the recent literature with a data sample that allowed for increased statistical power compared to previous experiments. Relying on traditional frequentist analysis, we found no effect of focused attention and open monitoring meditation on the auditory MMN amplitude compared to a control condition (silent movie) in expert or novice practitioners (all p > 0.17), providing a non-replication of our previous work (Fucci et al. 2018). Using a Bayesian approach, we found strong evidence against an interaction effect on the MMN amplitude between expertise groups and meditation practices (BF = 11.0), strong evidence against effects of either meditation practices compared to the control condition (BF between 11.9 and 16.1) and moderate evidence against an effect of expertise during meditation (BF between 5.3 and 7.9). On the other hand, we replicated previous evidence of increased alpha oscillatory power during meditation practices compared to a control state (p < 0.001). We discuss our null findings in relation to factors that could undermine the replicability of previous research on this subject, namely low statistical power, use of flexible analysis methods and a possible publication bias leading to a misrepresentation of the available evidence.
10.1016/j.ijpsycho.2022.03.010
The effects of a short-term meditation-based mindfulness protocol in patients receiving hemodialysis.
Psychology, health & medicine
Mindfulness-based approaches that promote health, improve quality of life, and reduce the impact of comorbidities are key aspects in chronic diseases management. We aimed to verify the impact of a short-term meditation protocol on psychosocial and physiological parameters in chronic hemodialysis patients. We enrolled twenty-two patients, median age of 69.5 years old, into a 12-week meditation protocol that occurred during each hemodialysis session for 10-20 minutes, 3x/week, in a private tertiary hospital. We then evaluated clinical, psychological, and laboratorial parameters pre- and post-meditation. Patients exhibited a better control of serum phosphorus (-0.72 mg/dL; = 0.002), a decrease in systolic blood pressure (-1.90 mmHg; = 0.009), a 23% decrease in depressive symptoms ( = 0.014), and an increase of 7% in the self-compassion scale ( = 0.048) after meditation. To note, we observed an increase in 13% of the mindfulness score ( = 0.019). Our preliminary study describes the effects of a short-term meditation protocol in chronic hemodialysis setting. We observed a decrease in depressive symptoms and in blood pressure values, an improvement in self-compassion and serum phosphorous levels. In conjunction with the promising results of meditation in chronic kidney disease setting, this encouraging preliminary study supports the need for additional clinical trials.
10.1080/13548506.2021.1871769
The heart-brain axis: A proteomics study of meditation on the cardiovascular system of Tibetan Monks.
EBioMedicine
BACKGROUND:There have been mixed reports on the beneficial effects of meditation in cardiovascular disease (CVD), which is widely considered the leading cause of death worldwide. METHODS:To clarify the role of meditation in modulating the heart-brain axis, we implemented an extreme phenotype strategy, i.e., Tibetan monks (BMI > 30) who practised 19.20 ± 7.82 years of meditation on average and their strictly matched non-meditative Tibetan controls. Hypothesis-free advanced proteomics strategies (Data Independent Acquisition and Targeted Parallel Reaction Monitoring) were jointly applied to systematically investigate and target the plasma proteome underlying meditation. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B) and lipoprotein (a) [Lp(a)] as the potential cardiovascular risk factors were evaluated. Heart rate variability (HRV) was assessed by electrocardiogram. FINDINGS:Obesity, hypertension, and reduced HRV is offset by long-term meditation. Notably, meditative monks have blood pressure and HRV comparable to their matched Tibetan controls. Meditative monks have a protective plasma proteome, related to decreased atherosclerosis, enhanced glycolysis, and oxygen release, that confers resilience to the development of CVD. In addition, clinical risk factors in plasma were significantly decreased in monks compared with controls, including total cholesterol, LDL-C, Apo B, and Lp(a). INTERPRETATION:To our knowledge, this work is the first well-controlled proteomics investigation of long-term meditation, which opens up a window for individuals characterized by a sedentary lifestyle to improve their cardiovascular health with an accessible method practised for more than two millennia. FUNDING:See the Acknowledgements section.
10.1016/j.ebiom.2022.104026
Using meditation in a control vs. acceptance context: A preliminary evaluation of relations with anxiety, depression, and indices of well-being.
Journal of clinical psychology
BACKGROUND AND OBJECTIVES:Meditation practices have been marketed broadly to ameliorate human suffering. As such, individuals may seek out and use meditation to control or manage unpleasant thoughts and emotions. Emotion and thought control research suggest that meditation used in this way may potentiate unpleasant private experiences and contribute to negative outcomes. We aimed to evaluate the function or purpose guiding meditation and its relations with anxiety, depression, and other indices of well-being. DESIGN AND METHODS:In a cross-sectional design, undergraduate meditators (N = 98) reported intentions guiding their meditation practice (i.e., experiential/emotional control or acceptance/openness) and completed an assessment battery. RESULTS:Most participants (58.2%) indicated using meditation to manage, control, or avoid difficult experiences. Participants using meditation with control-based intentions reported greater worry, anxiety, depression, negative affect, and lower mindfulness relative to their acceptance-guided counterparts. After controlling for level of anxiety, viewing anxiety as a problem increased the likelihood of using meditation with control-based intentions. Similar relations were observed between viewing stress as a problem and the likelihood of using meditation for experiential control. CONCLUSIONS:Findings suggest that (a) how people meditate is significantly related to psychological distress and (b) highlight the importance of evaluating intentions guiding meditative practices, particularly in individuals struggling with unpleasant emotional or psychological experiences.
10.1002/jclp.23313
Individual differences in meditation interventions: A meta-analytic study.
British journal of health psychology
OBJECTIVES:Meditation interventions typically show small to moderate effects on health and well-being, but we know little about how these effects vary across individuals. This meta-analytic study investigates the relationship between baseline participant characteristics and the outcomes of meditation. METHODS:A systematic search yielded 51 eligible studies with 7782 participants. A combination of subgroup analyses and meta-regression based on the random-effects model were used. RESULTS:We found that a higher baseline level of psychopathology or depression was associated with deterioration in mental health after a meditation intervention. On the other hand, participants with higher scores on interpersonal variables, motivation, medical conditions, and mindfulness showed higher levels of positive meditation outcomes. Higher well-being and stress were simultaneously associated with moderate increases in negative and positive meditation outcomes. Participant demographics, psychological traits, self-concept, and length of meditation practice did not significantly influence the response to meditation. CONCLUSIONS:Overall, we found that meditation interventions affect participants differently, and identified some of the individual characteristics that should be considered when using meditation interventions.
10.1111/bjhp.12589
Effects of meditation on physiological and metabolic parameters in patients with type 2 diabetes mellitus "MindDM": study protocol for a randomized controlled trial.
Trials
BACKGROUND:Sri Lanka is faced with the challenge of managing a large population with diabetes mellitus by 2030. Psychological stress plays a major role in disease outcome by exerting physiological, psychological and social effects on individuals with chronic disorders. Meditation-based interventions have positive effects on the management of stress and diabetes, which are mediated via modulation of neuro-humoral mechanisms and autonomic functions, among others. Mechanisms of bio-physiological effects of meditation are considered to be through reduction of stress hormones, improvement of insulin resistance and improvement of autonomic dysfunction. METHODS:This study will be conducted as an open-label, randomized controlled clinical trial in the Faculty of Medicine, University of Colombo. The aim is to investigate the effects of meditation on glycaemic control and possible mechanisms of how meditation affects glycaemic control in patients with type 2 diabetes. The study was approved by the Ethics Review Committee of the Faculty of Medicine, University of Colombo (ERC/2019/094). Patients who are attending the professorial unit medical clinic with type 2 diabetes (172 in total) will be recruited based on inclusion-exclusion criteria. Patients who have never meditated or rarely meditated (less than once every three months) will be randomized using block randomization to meditation and waitlisted arms (1:1 allocation ratio). The meditation arm will undergo a mindfulness meditation program (selected after studying several meditation methods) conducted by a qualified instructor weekly for a period of 12 weeks in addition to usual care, while the waitlisted arm will only receive usual care. Daily meditation practices will be recorded in a diary. The primary outcome measure is HbA1c. Secondary outcome measures are fasting blood sugar, fructosamine, insulin resistance (calculated using fasting serum insulin), 24-h urinary cortisol, body mass index, cardiac autonomic reflex testing (Ewing's battery of tests) and orocecal transit time using hydrogen breath analysis. All these will be done prior to commencement of the intervention and after 3 months in both arms. Data will be analysed using SPSS V-23. DISCUSSION:This study aims to identify the effect of mindfulness meditation on glycaemic control and the possible mechanisms (neuro humoral and autonomic functions) by which beneficial effects are mediated. TRIAL REGISTRATION:Registered under Sri Lanka Clinical Trial Registry: SLCTR/2021/015 The Universal Trial Number (UTN) U1111-1266-8640.
10.1186/s13063-022-06771-2
Focused attention meditation in healthy adults: A systematic review and meta-analysis of cross-sectional functional MRI studies.
Neuroscience and biobehavioral reviews
Meditation trains the mind to focus attention towards an object or experience. Among different meditation techniques, focused attention meditation is considered foundational for more advanced practices. Despite renewed interest in its functional neural correlates, there is no unified neurocognitive model of focused attention meditation developed via quantitative synthesis of contemporary literature. Hence, we performed a quantitative systematic review and meta-analysis of all functional MRI studies examining focussed attention meditation. Following PRISMA guidelines, 28 studies were included in this review, of which 10 studies (200 participants) were amenable to activation likelihood estimation meta-analysis. We found that regions comprising three key functional brain networks i.e., Default-mode, Salience, and Executive Control, were consistently implicated in focused attention meditation. Furthermore, meditation expertise, mindfulness levels and attentional skills were found to significantly influence the magnitude, but not regional extent, of activation and functional connectivity in these networks. Aggregating all evidence, we present a unified neurocognitive brain-network model of focused attention meditation.
10.1016/j.neubiorev.2022.104846
Embodied Cognition in Meditation, Yoga, and Ethics-An Experimental Single-Case Study on the Differential Effects of Four Mind-Body Treatments.
International journal of environmental research and public health
Yoga is an embodied contemplative practice considered as a path toward long-term well-being, which fosters an integrated processing of bodily and emotional stimuli. However, little is known about how the different components of yoga contribute to these processes. This was the aim of this single-case multiple-baseline study. Herein, we explored how different yoga components affect body awareness, emotion regulation, affectivity, self-compassion, and distress tolerance. Forty-two randomly assigned participants (from initially fifty-seven) completed one of four 8-week treatments: Mantra meditation alone (MA), meditation plus physical yoga (MY), meditation plus ethical education (ME), and meditation plus yoga and ethical education (MYE). Participants had no prior regular yoga or meditation practice. Data were analyzed using visual inspection, effect size estimation, and multilevel modeling. Surprisingly, all four treatments similarly improved body awareness (Tau- = 0.21 to Tau- = 0.49), emotion regulation (Tau- = -0.43 to Tau- = -0.52), self-compassion (η = 0.08), and distress tolerance (η = 0.13). These effects were maintained until follow-up at 2 and 12 months after the study, even though home practice declined. The MA condition had the least favorable effect on affective experience (Tau- = -0.14 and 0.07), while the ME condition enhanced valence the most (Tau- = 0.10) and the MY condition was the most effective in preventing negative affective responses. Although mantra meditation on its own negatively influenced daily affect, it can be assumed as the driving force behind the improvement in the other variables. This points to the central role of meditation in increasing interoception, self-awareness, and embodied processing.
10.3390/ijerph191811734
Personalized Prediction of Response to Smartphone-Delivered Meditation Training: Randomized Controlled Trial.
Journal of medical Internet research
BACKGROUND:Meditation apps have surged in popularity in recent years, with an increasing number of individuals turning to these apps to cope with stress, including during the COVID-19 pandemic. Meditation apps are the most commonly used mental health apps for depression and anxiety. However, little is known about who is well suited to these apps. OBJECTIVE:This study aimed to develop and test a data-driven algorithm to predict which individuals are most likely to benefit from app-based meditation training. METHODS:Using randomized controlled trial data comparing a 4-week meditation app (Healthy Minds Program [HMP]) with an assessment-only control condition in school system employees (n=662), we developed an algorithm to predict who is most likely to benefit from HMP. Baseline clinical and demographic characteristics were submitted to a machine learning model to develop a "Personalized Advantage Index" (PAI) reflecting an individual's expected reduction in distress (primary outcome) from HMP versus control. RESULTS:A significant group × PAI interaction emerged (t=3.30; P=.001), indicating that PAI scores moderated group differences in outcomes. A regression model that included repetitive negative thinking as the sole baseline predictor performed comparably well. Finally, we demonstrate the translation of a predictive model into personalized recommendations of expected benefit. CONCLUSIONS:Overall, the results revealed the potential of a data-driven algorithm to inform which individuals are most likely to benefit from a meditation app. Such an algorithm could be used to objectively communicate expected benefits to individuals, allowing them to make more informed decisions about whether a meditation app is appropriate for them. TRIAL REGISTRATION:ClinicalTrials.gov NCT04426318; https://clinicaltrials.gov/ct2/show/NCT04426318.
10.2196/41566